Incidence of Acute Exacerbation of Interstitial Pneumonia in Operated Lung Cancer: Institutional Report and Review

• Published in: Annals of Thoracic and Cardiovascular Surgery Vol. 18; no. 4; pp. 314 - 317
• Main Authors: Chida, Masayuki, Kobayashi, Satoru, Karube, Yoko, Hayama, Makio, Tamura, Motohiko, Ishihama, Hiromi, Oyaizu, Takeshi
• Format: Journal Article
• Language: English
• Published: Japan The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery 2012
• Subjects: Acute Disease; acute exacerbation; Carcinoma, Non-Small-Cell Lung - epidemiology; Carcinoma, Non-Small-Cell Lung - mortality; Carcinoma, Non-Small-Cell Lung - surgery; Comorbidity; complication; Disease Progression; Humans; Idiopathic Interstitial Pneumonias - epidemiology; Idiopathic Interstitial Pneumonias - mortality; idiopathic pulmonary fibrosis; Idiopathic Pulmonary Fibrosis - epidemiology; Incidence; interstitial pneumonia; Japan - epidemiology; lung cancer; Lung Neoplasms - epidemiology; Lung Neoplasms - mortality; Lung Neoplasms - surgery; Pneumonectomy - adverse effects; Pneumonectomy - mortality; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Japan
• ISSN: 1341-1098; 2186-1005
• DOI: 10.5761/atcs.oa.11.01839

Purpose: Several small studies have reported that acute exacerbation (AE) of idiopathic interstitial pneumonia (IIP) can occur after lung resection for patients with non-small cell lung cancer, though the incidence rate is unclear. Methods: We examined our institutional data and performed a search of the MEDLINE database for publications regarding AE of IIP following surgery for lung cancer. Studies reporting the incidence rates of IIP and AE were included. Results: Eleven studies including our institutional data were determined to be eligible. Seven studies designated the incidence of IIP. Of 4749 patients (from 7 studies) who underwent lung resection for NSCLC, 277 had IIP, for an incidence rate of 5.8% (range 1.1%-11.7%). Eleven studies designated the incidence of AE from IIP patient, 67 (15.8%) of 424 IIP patients (from 11 studies) developed AE after surgery, of whom 38 (56.7%) died during the postoperative course. Conclusion: Coexistent IIP in patients with lung cancer increases the risk of lung cancer surgery. Furthermore, AE of IIP may be a major cause of operation-related death.