Synthesis and systematic review of reported neonatal SARS-CoV-2 infections
A number of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections have been reported in neonates. Here, we aim to clarify the transmission route, clinical features and outcomes of these infections. We present a meta-analysis of 176 published cases of neonatal SARS-CoV-2 infections...
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Published in | Nature communications Vol. 11; no. 1; pp. 5164 - 10 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
15.10.2020
Nature Publishing Group Nature Portfolio |
Subjects | |
Online Access | Get full text |
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Summary: | A number of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections have been reported in neonates. Here, we aim to clarify the transmission route, clinical features and outcomes of these infections. We present a meta-analysis of 176 published cases of neonatal SARS-CoV-2 infections that were defined by at least one positive nasopharyngeal swab and/or the presence of specific IgM. We report that 70% and 30% of infections are due to environmental and vertical transmission, respectively. Our analysis shows that 55% of infected neonates developed COVID-19; the most common symptoms were fever (44%), gastrointestinal (36%), respiratory (52%) and neurological manifestations (18%), and lung imaging was abnormal in 64% of cases. A lack of mother–neonate separation from birth is associated with late SARS-CoV-2 infection (OR 4.94 (95% CI: 1.98–13.08),
p
= 0.0002; adjusted OR 6.6 (95% CI: 2.6–16),
p
< 0.0001), while breastfeeding is not (OR 0.35 (95% CI: 0.09–1.18),
p
= 0.10; adjusted OR 2.2 (95% CI: 0.7–6.5),
p
= 0.148). Our findings add to the literature on neonatal SARS-CoV-2 infections.
There are a growing number of reports of neonatal SARS-CoV-2 infections. Here, De Luca and colleagues systematically analyse 176 published cases to better understand the route of transmission, as well as the clinical features and outcomes of neonatal COVID-19. |
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ISSN: | 2041-1723 2041-1723 |
DOI: | 10.1038/s41467-020-18982-9 |