Reduced-intensity unrelated cord blood transplantation for treatment of metastatic renal cell carcinoma: first evidence of cord-blood-versus-solid-tumor effect

• Published in: Bone marrow transplantation (Basingstoke) Vol. 38; no. 11; pp. 729 - 732
• Main Authors: TAKAMI, A, TAKAMATSU, H, YAMAZAKI, H, ISHIYAMA, K, OKUMURA, H, OHATA, K, KONAKA, H, ASAKURA, H, NAMIKI, M, NAKAO, S
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.12.2006
• Subjects: Aged; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Blood; Bone marrow, stem cells transplantation. Graft versus host reaction; Carcinoma, Renal cell; Carcinoma, Renal Cell - pathology; Carcinoma, Renal Cell - therapy; Care and treatment; Case studies; Cord blood; Cord Blood Stem Cell Transplantation; Cytokines; Diagnosis; Graft versus host reaction; Graft vs Host Disease - complications; Graft vs Tumor Effect; Grafting; Health aspects; Hematopoietic stem cells; Humans; Kidney cancer; Kidney Neoplasms - pathology; Kidney Neoplasms - therapy; Kidneys; Male; Medical sciences; Metastases; Metastasis; Neoplasm Metastasis - therapy; Nephrology. Urinary tract diseases; Patients; Renal cell carcinoma; Risk factors; Solid tumors; Stem cell transplantation; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Transplantation; Transplantation Conditioning - methods; Transplantation, Homologous; Treatment Outcome; Tumors; Tumors of the urinary system; Japan; Kidney disease; Solid tumor; Urinary system disease; Carcinoma; Hematology; Graft versus tumor reaction; Stem cell; reduced-intensity unrelated cord blood transplantation; Hematopoietic cell; Homograft; metastatic renal cell carcinoma; Malignant tumor; Non myeloablative treatment; Metastasis; graft-versus- tumor effect; Blood; Blood cell; Treatment; Kidney cancer; Graft; Grawitz tumor; Advanced stage; Umbilical cord; Comparative study
• ISSN: 0268-3369; 1476-5365
• DOI: 10.1038/sj.bmt.1705519

We report a 69-year-old man with cytokine-resistant metastatic renal cell carcinoma treated with reduced-intensity unrelated cord blood transplantation. The patient achieved durable donor engraftment with minimal graft-versus-host disease. The patient showed regression of metastatic disease, providing the first evidence of a graft-versus-tumor effect on a solid tumor resulting from cord blood graft.