Aerobic glycolysis and high level of lactate in cancer metabolism and microenvironment

Metabolic abnormalities is a hallmark of cancer. About 100 years ago, Nobel laureate Otto Heinrich Warburg first described high rate of glycolysis in cancer cells. Recently more and more novel opinions about cancer metabolism supplement to this hypothesis, consist of glucose uptake, lactic acid gene...

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Bibliographic Details
Published inGenes & diseases Vol. 4; no. 1; pp. 25 - 27
Main Author Jiang, Bo
Format Journal Article
LanguageEnglish
Published China Elsevier B.V 01.03.2017
Chongqing Medical University
KeAi Communications Co., Ltd
Subjects
Aerobic glycolysis
Cancer metabolism
Glucose metabolism
Immune escape
Lactate
Glucose metabolism
Aerobic glycolysis
Cancer metabolism
Lactate
Immune escape
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Summary:Metabolic abnormalities is a hallmark of cancer. About 100 years ago, Nobel laureate Otto Heinrich Warburg first described high rate of glycolysis in cancer cells. Recently more and more novel opinions about cancer metabolism supplement to this hypothesis, consist of glucose uptake, lactic acid generation and secretion, acidification of the microenvironment and cancer immune evasion. Here we briefly review metabolic pathways generating lactate, and discuss the function of higher lactic acid in cancer microenvironments.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2352-3042
2352-3042
DOI:10.1016/j.gendis.2017.02.003