Understanding the Physiological Links Between Physical Frailty and Cognitive Decline

Declines in both physical and cognitive function are associated with increasing age. Understanding the physiological link between physical frailty and cognitive decline may allow us to develop interventions that prevent and treat both conditions. Although there is significant epidemiological evidenc...

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Bibliographic Details
Published inAging and disease Vol. 11; no. 2; pp. 405 - 418
Main Authors Ma, Lina, Chan, Piu
Format Journal Article
LanguageEnglish
Published United States JKL International 01.04.2020
JKL International LLC
Subjects
Epidemiology
Inflammation
Physiological aspects
Review
Type 2 diabetes
China
biology
physical frailty
cognitive decline
cognitive frailty
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Summary:Declines in both physical and cognitive function are associated with increasing age. Understanding the physiological link between physical frailty and cognitive decline may allow us to develop interventions that prevent and treat both conditions. Although there is significant epidemiological evidence linking physical frailty to cognitive decline, a complete understanding of the underpinning biological basis of the two disorders remains fragmented. This narrative review discusses insights into the potential roles of chronic inflammation, impaired hypothalamic-pituitary axis stress response, imbalanced energy metabolism, mitochondrial dysfunction, oxidative stress, and neuroendocrine dysfunction linking physical frailty with cognitive decline. We highlight the importance of easier identification of strategic approaches delaying the progression and onset of physical frailty and cognitive decline as well as preventing disability in the older population.
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ISSN:2152-5250
2152-5250
DOI:10.14336/ad.2019.0521