Pathophysiology of Autoimmune Bullous Diseases: Nature Versus Nurture

Pemphigus and pemphigoid are the prototypical immunobullous diseases. Although it has been well established that they are caused by deposition of autoreactive antibodies directed against adherence proteins within the skin, the specific genetic and environmental factors leading to development of thes...

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Published inIndian journal of dermatology Vol. 62; no. 3; pp. 262 - 267
Main Authors Patel, Forum, Wilken, Reason, Patel, Falin B, Sultani, Hawa, Bustos, Itzel, Duong, Christopher, Zone, John J, Raychaudhuri, Siba P, Maverakis, Emanual
Format Journal Article
LanguageEnglish
Published India Medknow Publications and Media Pvt. Ltd 01.05.2017
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
Subjects
Age
Antigens
Autoimmune blistering diseases
Autoimmune diseases
Bullous pemphigoid
Dermatology
desmoglein
Disease
IJD Symposium
Immunoglobulins
Pathological physiology
Patients
pemphigoid
Pemphigus
Proteins
Radiation therapy
Rheumatology
Risk factors
Skin diseases
United States > US
California
pemphigus
Autoimmune blistering diseases
desmoglein
pemphigoid
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Summary:Pemphigus and pemphigoid are the prototypical immunobullous diseases. Although it has been well established that they are caused by deposition of autoreactive antibodies directed against adherence proteins within the skin, the specific genetic and environmental factors leading to development of these diseases continue to be an area of investigation. Herein, we discuss several of the potential environmental triggers that may induce patients to develop immunobullous diseases including medications, viral infections, UV exposure or other radiation injury and dietary factors. In addition, the potential genetic and immunologic mechanisms contributing to the pathogenesis of pemphigus and pemphigoid will be reviewed. The multifactorial nature of these diseases contributes to their complexity and highlights the importance of a detailed personal and family history when caring for these patients.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0019-5154
1998-3611
DOI:10.4103/0019-5154.159620