Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): A case report and review of literature

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a recently described inflammatory disease of central nervous system with distinct clinical and radiological features. The etiopathogenesis of this rare entity remains to be understood. The his...

Full description

Saved in:
Bibliographic Details
Published inAnnals of the Indian Academy of Neurology Vol. 18; no. 3; pp. 345 - 347
Main Authors Reddy, Soma Madhan, Lath, Rahul, Swain, Meenakshi, Ranjan, Alok
Format Journal Article
LanguageEnglish
Published India Medknow Publications and Media Pvt. Ltd 01.07.2015
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
Subjects
Brainstem mass
Care and treatment
Case Report
Case studies
CLIPPERS
Diagnosis
Immunology
Inflammatory diseases
Lymphocytosis
Pathogenesis
pontine lesion
Quadriplegia
Steroids
CLIPPERS
pontine lesion
Brainstem mass
Online AccessGet full text

Cover

More Information
Summary:Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a recently described inflammatory disease of central nervous system with distinct clinical and radiological features. The etiopathogenesis of this rare entity remains to be understood. The histopathological findings closely resemble chronic inflammatory diseases like sarcoidosis and malignancies like lymphoma. With advancements in serology, immunopathology and radiology CLIPPERS is identified as a distinct entity that differs considerably in its clinical presentation, immunopathology, radiological findings and response to steroids. We describe a case that presented to us with progressive quadriparesis and lower cranial nerve deficits whose radiological and pathological findings were consistent with CLIPPERS. The patient had a good outcome with long term immunosuppression.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0972-2327
1998-3549
DOI:10.4103/0972-2327.152085