The association between blood lipids and cognitive impairment in type 2 diabetes mellitus

• Published in: European journal of medical research Vol. 29; no. 1; p. 1
• Main Authors: Ma, Li, Yuan, Yue-Xing, Cheng, Feng-Jin, Liu, Yan, Wei, Qiong, Peng, You-Fan, Wang, Yao
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 02.01.2024; BioMed Central; BMC
• Subjects: Age; Apolipoprotein A-I; Apolipoproteins; Blood lipids; Body mass index; Cerebrospinal fluid; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cognitive ability; Cognitive Dysfunction - complications; Cognitive impairment; Confounding (Statistics); Dementia; Diabetes; Diabetes Mellitus, Type 2 - complications; Disease; Education; Gender; Hemoglobin; High density lipoprotein; Humans; Lipids; Lipoproteins; Liver; Low density lipoproteins; Medical research; Medicine, Experimental; Metabolism; Nervous system; Parkinson's disease; Regression analysis; Risk factors; Stroke; Triglycerides; Type 2 diabetes; Type 2 diabetes mellitus; Variables; Blood lipids; Type 2 diabetes mellitus; Cognitive impairment
• ISSN: 2047-783X; 0949-2321; 2047-783X
• DOI: 10.1186/s40001-023-01574-w

The study was performed to explore the association between blood lipids and cognitive impairment in patients with type 2 diabetes mellitus (T2DM). This study included 336 patients with T2DM. Relevant clinical data including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), apolipoprotein A1, apolipoprotein B were collected, and the Mini-Mental State Examination (MMSE) score and Montreal Cognitive Assessment (MoCA) score were used to assess the cognitive function in patients with T2DM. Serum apolipoprotein A1 levels were significantly increased in T2DM patients with cognitive impairment compared with T2DM patients without cognitive impairment (p = 0.017). Serum apolipoprotein A1 levels were significantly negatively correlated with MoCA score (r = - 0.143, p = 0.009) and MMSE score (r = - 0.132, p = 0.016) in patients with T2DM. In multivariable-adjusted regression model, serum apolipoprotein A1 was independently associated with cognitive impairment in patients with T2DM (OR = 5.201, p = 0.024). Serum apolipoprotein A1 is associated with cognitive impairment in patients with T2DM, but not TC, TG, HDL-C, LDL-C, and apolipoprotein B, indicating that increased serum apolipoprotein A1 may be a risk factor of cognitive impairment in patients with T2DM.