Hemophagocytic lymphohistiocytosis secondary to Epstein Barr virus and Leishmania co-infection in a toddler

This is the report of an EBV+Leishmanial co-infection. The patient developed hemophagocytic syndrome (HLH) and was treated with the standard HLH-2004 protocol. However, PCR in bone marrow discovered this secondary cause for HLH. In endemic countries, visceral leishmaniasis should be considered in th...

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Bibliographic Details
Published inJournal of postgraduate medicine Vol. 61; no. 1; pp. 44 - 45
Main Authors DomInguez-Pinilla, N, Baro-Fernández, M, González-Granado, L I
Format Journal Article
LanguageEnglish
Published India Medknow Publications and Media Pvt. Ltd 01.01.2015
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Subjects
Care and treatment
Case Report
Case studies
Causes of
Coinfection - drug therapy
Complications and side effects
Diagnosis
Epstein-Barr virus
Epstein-Barr virus diseases
Epstein-Barr Virus Infections - diagnosis
Epstein-Barr Virus Infections - drug therapy
Female
Health aspects
Herpesvirus 4, Human - isolation & purification
Humans
Infant
Infection
Leishmania
Leishmania donovani - isolation & purification
Leishmaniasis, Visceral - diagnosis
Leishmaniasis, Visceral - drug therapy
Lymphatic diseases
Lymphohistiocytosis, Hemophagocytic - diagnosis
Lymphohistiocytosis, Hemophagocytic - drug therapy
Polymerase Chain Reaction
Treatment Outcome
India
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Summary:This is the report of an EBV+Leishmanial co-infection. The patient developed hemophagocytic syndrome (HLH) and was treated with the standard HLH-2004 protocol. However, PCR in bone marrow discovered this secondary cause for HLH. In endemic countries, visceral leishmaniasis should be considered in the differential diagnosis even in EBV-related HLH, as chemotherapy toxicity may be avoided.
ISSN:0022-3859
0972-2823
DOI:10.4103/0022-3859.147052