Complex-Periodic Spiral Waves in Confluent Cardiac Cell Cultures Induced by Localized Inhomogeneities

Spatiotemporal wave activities in excitable heart tissues have long been the subject of numerous studies because they underlie different forms of cardiac arrhythmias. In particular, understanding the dynamics and the instabilities of spiral waves have become very important because they can cause ree...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 102; no. 29; pp. 10363 - 10368
Main Authors Hwang, Seong-min, Kim, Tae Yun, Lee, Kyoung J., Swinney, Harry L.
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences 19.07.2005
National Acad Sciences
SeriesFrom the Cover
Subjects
Action Potentials - physiology
Animals
Biological Sciences
Cardiac arrhythmia
Cell culture
Cell culture techniques
Cells, Cultured
Electrophysiology
Fibrillation
Heart Ventricles - cytology
Image analysis
Image Processing, Computer-Assisted
Inhomogeneity
Myocardial Contraction - physiology
Oscillation
Oscillometry
Rats
Spiral separators
Time series
Tissues
Trajectories
Ventricular Function
Waves
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Summary:Spatiotemporal wave activities in excitable heart tissues have long been the subject of numerous studies because they underlie different forms of cardiac arrhythmias. In particular, understanding the dynamics and the instabilities of spiral waves have become very important because they can cause reentrant tachycardia and their subsequent transitions to fibrillation. Although many aspects of cardiac spiral waves have been investigated through experiments and model simulations, their complex properties are far from well understood. Here, we show that intriguing complex-periodic (such as period-2, period-3, period-4, or aperiodic) spiral wave states can arise in monolayer tissues of cardiac cell culture in vitro, and demonstrate that these different dynamic states can coexist with abrupt and spontaneous transitions among them without any change in system parameters; in other words, the medium supports multistability. Based on extensive image data analysis, we have confirmed that these spiral waves are driven by their tips tracing complex orbits whose unusual, meandering shapes are formed by delicate interplay between localized conduction blocks and nonlinear properties of the culture medium.
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This paper was submitted directly (Track II) to the PNAS office.
To whom correspondence should be addressed. E-mail: kyoung@nld.korea.ac.kr.
Abbreviations: IBI, interbeat interval; P-n, period-n.
Edited by Harry L. Swinney, University of Texas, Austin, TX
Author contributions: S.-m.H. and K.J.L. designed research; S.-m.H. and T.Y.K. performed research; S.-m.H. contributed new reagents/analytic tools; S.-m.H., T.Y.K., and K.J.L. analyzed data; and S.-m.H. and K.J.L. wrote the paper.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0501539102