Unraveling the roles and mechanisms of mitochondrial translation in normal and malignant hematopoiesis

• Published in: Journal of hematology and oncology Vol. 17; no. 1; pp. 95 - 26
• Main Authors: Liu, Lianxuan, Shao, Mi, Huang, Yue, Qian, Pengxu, Huang, He
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 12.10.2024; BioMed Central; BMC
• Subjects: Animals; B cells; Biosynthesis; Blood; Blood diseases; Cell cycle; Cytoplasm; Genomes; Health aspects; Hematologic malignancy; Hematologic Neoplasms - metabolism; Hematologic Neoplasms - pathology; Hematopoiesis; Hematopoietic stem cells; Hemopoiesis; HSC; Humans; Immune cell; Kinases; Leukemia; Lymphocytes; Lymphoma; Malignancy; Medical prognosis; Mitochondria; Mitochondria - metabolism; Mitochondrial DNA; Mitochondrial translation; Protein Biosynthesis; Protein synthesis; Proteins; Review; Ribonucleic acid; RNA; T cell; T cells; Therapeutic targets; Transfer RNA; Translation; Yeast; HSC; Hematologic malignancy; Hematopoiesis; T cell; Immune cell; Mitochondrial translation
• ISSN: 1756-8722; 1756-8722
• DOI: 10.1186/s13045-024-01615-9

Due to spatial and genomic independence, mitochondria possess a translational mechanism distinct from that of cytoplasmic translation. Several regulators participate in the modulation of mitochondrial translation. Mitochondrial translation is coordinated with cytoplasmic translation through stress responses. Importantly, the inhibition of mitochondrial translation leads to the inhibition of cytoplasmic translation and metabolic disruption. Therefore, defects in mitochondrial translation are closely related to the functions of hematopoietic cells and various immune cells. Finally, the inhibition of mitochondrial translation is a potential therapeutic target for treating multiple hematologic malignancies. Collectively, more in-depth insights into mitochondrial translation not only facilitate our understanding of its functions in hematopoiesis, but also provide a basis for the discovery of new treatments for hematological malignancies and the modulation of immune cell function.