Clinical Features of Febrile Urinary Tract Infection Caused by Extended-spectrum Beta-lactamase-producing Escherichia Coli in Children

• Published in: Keio journal of medicine Vol. 69; no. 2; pp. 43 - 47
• Main Authors: Ohnishi, Takuma, Mishima, Yoshinori, Takizawa, Shohei, Tsutsumi, Kentaro, Amemiya, Atsuko, Akiyama, Nao, Kanna, Yukiko, Asato, Shinya, Tomita, Mizue, Ikemiyagi, Masako, Shikoro, Nobuaki, Nakazawa, Maki, Kurihara, Nobuyoshi, Kamimaki, Isamu
• Format: Journal Article
• Language: English
• Published: Japan The Keio Journal of Medicine 01.01.2020
• Subjects: Age Factors; Anti-Bacterial Agents - therapeutic use; beta-Lactamases - genetics; beta-Lactamases - metabolism; Cephalosporins - therapeutic use; Drug Resistance, Multiple, Bacterial - genetics; Escherichia coli - drug effects; Escherichia coli - enzymology; Escherichia coli - genetics; Escherichia coli - pathogenicity; Escherichia coli Infections - drug therapy; Escherichia coli Infections - epidemiology; Escherichia coli Infections - microbiology; Escherichia coli Infections - physiopathology; extended-spectrum beta-lactamase-producingEscherichia coli; febrile urinary tract infection; Female; Fever - drug therapy; Fever - epidemiology; Fever - microbiology; Fever - physiopathology; Gene Expression; Humans; Infant; Japan - epidemiology; Male; Prevalence; Retrospective Studies; risk factor; Risk Factors; Urinary Tract Infections - drug therapy; Urinary Tract Infections - epidemiology; Urinary Tract Infections - microbiology; Urinary Tract Infections - physiopathology; Japan; febrile urinary tract infection; risk factor; extended-spectrum beta-lactamase-producingEscherichia coli
• ISSN: 0022-9717; 1880-1293
• DOI: 10.2302/kjm.2019-0005-OA

The global prevalence of infections caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli has been increasing. In children, ESBL-producing E. coli manifest mostly as febrile urinary tract infections (fUTIs). This study aimed to elucidate the clinical features of fUTI resulting from ESBL-producing E. coli in Japanese patients. The clinical features of children with E. coli-related fUTI were retrospectively examined. These children underwent treatment at the National Hospital Organization Saitama Hospital, Japan, between May 2010 and April 2018. Urine specimens were obtained by either bladder catheterization or the clean-catch method. All children having positive urine cultures (≥104 colony-forming unit/mL for catheter specimens and ≥105 colony forming unit/mL for clean-catch specimens) and a fever of ≥38°C were considered to have fUTI. During the study period, 171 patients were diagnosed with E. coli-related fUTI. Among these, 17 (9.9%) fUTI cases were caused by ESBL-producing E. coli. A significant difference was noted in the median age of the populations having ESBL-producing E. coli and non-ESBL-producing E. coli infections (2 and 5 months, respectively); other characteristics were not significantly different between the two patient groups. ESBL-producing E. coli infections markedly increased in our hospital between 2013 and 2018. In the present study, young age was the only risk factor for fUTI caused by ESBL-producing E. coli identified in Japanese children.