肝组织炎症对FibroScan诊断慢性乙型肝炎患者肝纤维化的影响

目的探讨肝组织学炎症对瞬时弹性扫描仪（FS）诊断慢性乙型肝炎患者肝纤维化的影响。方法应用FS对124名慢性乙型肝炎患者进行肝穿刺前肝脏弹性测量值（LSM）的测定,采用肝穿刺活组织病理诊断技术进行肝纤维化分期（S）和炎症分级（G）。对同一肝纤维化分期不同肝组织炎症分级组间LSM进行比较,并对各肝纤维化分期中LSM与肝组织炎症分级进行相关性分析。结果肝组织纤维化逐渐发展伴随肝炎症程度加重,如肝纤维化S1期患者中以G1为主（81.8%）,S2期以G2为主（54.2%）,S3期以G3为主（47.4%）,S4期以G3、G4为主（40%,33.4%）,S1～S4每一纤维化分期水平上,不同炎症分级LSM差异...

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Published in临床肝胆病杂志 Vol. 29; no. 5; pp. 336 - 338
Main Author 刘志权 冯军花 叶立红 孝奇 杜瑞清 戴二黑
Format Journal Article
LanguageChinese
Published 石家庄市第五医院检验科,石家庄,050021%河北医科大学第四医院检验科,石家庄,050011%石家庄市第五医院影像科,石家庄,050021%石家庄市第五医院超声科,石家庄,050021 2013
Subjects
瞬时弹性扫描
肝炎,乙型,慢性
肝硬化
肝脏弹性测量值
肝脏弹性测量值
肝炎,乙型,慢性
肝硬化
瞬时弹性扫描
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Summary:目的探讨肝组织学炎症对瞬时弹性扫描仪（FS）诊断慢性乙型肝炎患者肝纤维化的影响。方法应用FS对124名慢性乙型肝炎患者进行肝穿刺前肝脏弹性测量值（LSM）的测定,采用肝穿刺活组织病理诊断技术进行肝纤维化分期（S）和炎症分级（G）。对同一肝纤维化分期不同肝组织炎症分级组间LSM进行比较,并对各肝纤维化分期中LSM与肝组织炎症分级进行相关性分析。结果肝组织纤维化逐渐发展伴随肝炎症程度加重,如肝纤维化S1期患者中以G1为主（81.8%）,S2期以G2为主（54.2%）,S3期以G3为主（47.4%）,S4期以G3、G4为主（40%,33.4%）,S1～S4每一纤维化分期水平上,不同炎症分级LSM差异均具有统计学意义（P〈0.05）,且LSM与不同炎症分级之间均呈显著正相关（P〈0.01）。结论肝组织炎症程度是影响FS诊断的一个重要因素,炎症活动程度加重可使LSM增加。
Bibliography:LIU Zhiquan,FENG Junhua,YE Lihong,et al.（Department of Inspection,The Fifth Hospital of Shijiazhuang,Shijiazhuang 050021,China）
Objective To investigate the influence of liver inflammation on the ability of the FibroScan non-invasive elastrography scanner to diagnose hepatic fibrosis in patients with chronic hepatitis B（CHB）.Methods A total of 124 CHB patients who received liver biopsy and concomitant liver stiffness measurement（LSM） by FibroScan between June 2011 and February 2012 were enrolled in the study.The liver puncture biopsies were subjected to histological analysis to determine fibrosis stage（S1 to S4,mild fibrosis to severe fibrosis or cirrhosis） and inflammation grade（G1 to G4,low to high extent of inflammation）.Differences between groups were assessed by Kruskal-Wallis H test or Mann-Whitney U test.The correlations between LSM and fibrosis stages and inflammation grades were evaluated by Spearman＇s rank correlation coefficient.Results The progressive fibrosis stages were accompanied by increased i
ISSN:1001-5256