Correlation between Interleukin-17 gene polymorphism and osteoarthritis susceptibility in Han Chinese population

• Published in: BMC medical genetics Vol. 20; no. 1; p. 20
• Main Authors: Bai, Yuming, Gao, Shijun, Liu, Ying, Jin, Shengli, Zhang, Haisen, Su, Ke
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18.01.2019; BioMed Central; BMC
• Subjects: Age; Aged; Alleles; Asian Continental Ancestry Group - ethnology; Asian Continental Ancestry Group - genetics; Breast cancer; Case-Control Studies; Chemokines; China - ethnology; Cytokines; Deoxyribonucleic acid; Disease; Disease susceptibility; DNA; EDTA; Female; Gastric cancer; Gene polymorphism; Genes; Genetic aspects; Genetic Association Studies; Genetic polymorphisms; Genetic Predisposition to Disease; Genomes; Genotypes; Han (Chinese people); Haplotypes; Health aspects; Humans; IL-17A; IL-17F; Inflammation; Inflammatory bowel disease; Inflammatory diseases; Interleukin 17; Interleukin-17 - blood; Interleukin-17 - genetics; Interleukins; Knee; Male; Medical research; Middle Aged; Osteoarthritis; Osteoarthritis, Knee - blood; Osteoarthritis, Knee - ethnology; Osteoarthritis, Knee - genetics; Pathogenesis; Polymerase chain reaction; Polymorphism; Polymorphism, Single Nucleotide; Population; Population studies; Principal components analysis; Restriction fragment length polymorphism; Rheumatoid arthritis; Rheumatology; Risk factors; Sequence Analysis, DNA; Severity of Illness Index; Smoking; Studies; China; Inflammation; IL-17F; IL-17A; Osteoarthritis; Polymorphism

Interleukin-17 (IL-17), a pleiotropic cytokine, plays a significant role in the inflammatory diseases. By a pilot study with small population, IL-17 polymorphisms (IL-17A rs2275913 and IL-17F rs763780) showed a more potential risk factor in knee osteoarthritis (OA) in our recruited subjects. In the...