A Multicenter Randomized Trial of Computer-driven Protocolized Weaning from Mechanical Ventilation

• Published in: American journal of respiratory and critical care medicine Vol. 174; no. 8; pp. 894 - 900
• Main Authors: Lellouche, Franccois, Mancebo, Jordi, Jolliet, Philippe, Roeseler, Jean, Schortgen, Frederique, Dojat, Michel, Cabello, Belen, Bouadma, Lila, Rodriguez, Pablo, Maggiore, Salvatore, Reynaert, Marc, Mersmann, Stefan, Brochard, Laurent
• Format: Journal Article
• Language: English
• Published: New York, NY Am Thoracic Soc 15.10.2006; American Lung Association; American Thoracic Society
• Subjects: Aged; Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Artificial Intelligence; Bioengineering; Biological and medical sciences; Clinical Protocols; Compliance; Computer Science; Computerized, statistical medical data processing and models in biomedicine; Emergency and intensive respiratory care; Extubation; Female; Follow-Up Studies; Human health and pathology; Humans; Intensive care; Intensive care medicine; Intensive Care Units; Length of Stay; Life Sciences; Male; Medical computing and teaching; Medical sciences; Middle Aged; Ostomy; Patients; Pulmonology and respiratory tract; Respiratory Insufficiency; Respiratory Insufficiency - therapy; Retrospective Studies; Therapy, Computer-Assisted; Therapy, Computer-Assisted - methods; Treatment Outcome; Ventilator Weaning; Ventilator Weaning - methods; Ventilators; Weaning; France; Intensive care; Multicenter study; computers; extubation; knowledge-based system; mechanical ventilation; weaning protocols; Mechanical ventilation; Extubation; Resuscitation

Duration of weaning from mechanical ventilation may be reduced by the use of a systematic approach. We assessed whether a closed-loop knowledge-based algorithm introduced in a ventilator to act as a computer-driven weaning protocol can improve patient outcomes as compared with usual care. We conduct...