Transductional targeting of adenovirus vectors for gene therapy

Cancer gene therapy approaches will derive considerable benefit from adenovirus (Ad) vectors capable of self-directed localization to neoplastic disease or immunomodulatory targets in vivo. The ablation of native Ad tropism coupled with active targeting modalities has demonstrated that innate gene d...

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Bibliographic Details
Published inCancer gene therapy Vol. 13; no. 9; pp. 830 - 844
Main Authors Glasgow, J N, Everts, M, Curiel, D T
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.09.2006
Subjects
Adenoviridae - genetics
Adenovirus
Adenoviruses
Cancer
Care and treatment
Expression vectors
Gene Targeting - methods
Gene therapy
Gene transfer
Genetic aspects
Genetic Therapy - methods
Genetic Vectors - genetics
Health aspects
Humans
Immunomodulation
Localization
Methods
Nanotechnology - trends
Neoplasms - genetics
Neoplasms - therapy
Physiological aspects
Receptors, Virus - metabolism
Review
Transduction, Genetic - methods
Tropism
Vectors (Biology)
United States
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Summary:Cancer gene therapy approaches will derive considerable benefit from adenovirus (Ad) vectors capable of self-directed localization to neoplastic disease or immunomodulatory targets in vivo. The ablation of native Ad tropism coupled with active targeting modalities has demonstrated that innate gene delivery efficiency may be retained while circumventing Ad dependence on its primary cellular receptor, the coxsackie and Ad receptor. Herein, we describe advances in Ad targeting that are predicated on a fundamental understanding of vector/cell interplay. Further, we propose strategies by which existing paradigms, such as nanotechnology, may be combined with Ad vectors to form advanced delivery vehicles with multiple functions.
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ISSN:0929-1903
1476-5500
DOI:10.1038/sj.cgt.7700928