Relationship between vascular endothelial growth factor -2578C > a gene polymorphism and lung cancer risk: a meta-analysis

• Published in: BMC medical genetics Vol. 21; no. 1; p. 17
• Main Authors: Zhao, Hui-Liu, Yu, Jia-Hua, Huang, Ling-Sha, Li, Pei-Zhang, Lao, Ming, Zhu, Bo, Ou, Chao
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 29.01.2020; BioMed Central; BMC
• Subjects: 2578C > A; Alleles; Asian Continental Ancestry Group - genetics; Asian people; Asians; Bias; Cancer genetics; Databases, Factual; Disease susceptibility; Endothelial growth factors; Gene expression; Gene Frequency; Gene polymorphism; Genes; Genetic aspects; Genetic Association Studies; Genetic polymorphisms; Genetic Predisposition to Disease; Genotype; Genotype & phenotype; Health aspects; Humans; Lung cancer; Lung Neoplasms - ethnology; Lung Neoplasms - genetics; Meta-analysis; Odds Ratio; Polymorphism; Polymorphism, Single Nucleotide; Population; Population genetics; Risk factors; Sensitivity analysis; Studies; Vascular endothelial growth factor; Vascular endothelial growth factor (VEGF); Vascular Endothelial Growth Factor A - genetics; Vascular Endothelial Growth Factor C - genetics; White people; China; Gene polymorphism; Lung cancer; Vascular endothelial growth factor (VEGF); 2578C > A; Meta-analysis
• ISSN: 1471-2350; 1471-2350
• DOI: 10.1186/s12881-019-0938-0

Several reports were published on the relationship between the vascular endothelial growth factor (VEGF) -2578C > A gene polymorphism and lung cancer risk; however, the results are debatable. This meta-analysis was conducted to assess the relationship between VEGF -2578C > A gene polymorphism and lung cancer risk. The associated literatures were identified on the 1st of September 2018 from CBM-disc (China Biological Medicine Database) and PubMed. A total of 14 reports were recruited into our meta-analysis to assess the association between VEGF -2578C > A gene polymorphism and lung cancer susceptibility. There was a marked association between VEGF -2578C > A A allele / CC genotype and lung cancer risk in overall and Asian populations (overall populations: A allele: OR = 1.26, 95% CI: 1.08-1.46, P = 0.003; CC genotype: OR = 0.72, 95% CI: 0.54-0.95, P = 0.02; Asians: A allele: OR = 1.33, 95% CI: 1.15-1.55, P = 0.0002; CC genotype: OR = 0.68, 95% CI: 0.50-0.93, P = 0.01). However, VEGF -2578C > A gene polymorphism was not associated with the risk of lung cancer in Caucasians. VEGF -2578C > A A allele / CC genotype is associated with the lung cancer susceptibility in Asians and in overall populations.