Principles and innovative technologies for decrypting noncoding RNAs: from discovery and functional prediction to clinical application

Noncoding RNAs (ncRNAs) are a large segment of the transcriptome that do not have apparent protein-coding roles, but they have been verified to play important roles in diverse biological processes, including disease pathogenesis. With the development of innovative technologies, an increasing number...

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Published inJournal of hematology and oncology Vol. 13; no. 1; pp. 109 - 27
Main Authors Sun, Yu-Meng, Chen, Yue-Qin
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 10.08.2020
BioMed Central
BMC
Subjects
Cancer
Chromatin - genetics
Classification
Databases, Genetic
Diagnostic kits
Functional ncRNA discovery
Gene expression
Gene Expression Regulation
Genes
Genomes
Health aspects
Hematology
High-Throughput Nucleotide Sequencing
Humans
Identification
Identification and classification
Mammals
Methods
Microarray Analysis
Models, Genetic
ncRNA database
Neoplasms - genetics
Neoplasms - metabolism
Next-generation sequencing
Non-coding RNA
Novel ncRNAs
Oncology
Open Reading Frames - genetics
Organ Specificity
Principles
Protein Biosynthesis
Proteins
Review
Ribosomes - metabolism
RNA
RNA sequencing
RNA, Neoplasm - genetics
RNA, Neoplasm - physiology
RNA, Untranslated - classification
RNA, Untranslated - genetics
RNA, Untranslated - isolation & purification
RNA, Untranslated - physiology
RNA-Seq
Sequencing technologies
Single-Cell Analysis
Structure
Subcellular Fractions - chemistry
Subcellular localization
Transcription, Genetic
China
ncRNA database
Sequencing technologies
Diagnostic kits
Functional ncRNA discovery
Subcellular localization
Novel ncRNAs
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Abstract Noncoding RNAs (ncRNAs) are a large segment of the transcriptome that do not have apparent protein-coding roles, but they have been verified to play important roles in diverse biological processes, including disease pathogenesis. With the development of innovative technologies, an increasing number of novel ncRNAs have been uncovered; information about their prominent tissue-specific expression patterns, various interaction networks, and subcellular locations will undoubtedly enhance our understanding of their potential functions. Here, we summarized the principles and innovative methods for identifications of novel ncRNAs that have potential functional roles in cancer biology. Moreover, this review also provides alternative ncRNA databases based on high-throughput sequencing or experimental validation, and it briefly describes the current strategy for the clinical translation of cancer-associated ncRNAs to be used in diagnosis.
AbstractList Noncoding RNAs (ncRNAs) are a large segment of the transcriptome that do not have apparent protein-coding roles, but they have been verified to play important roles in diverse biological processes, including disease pathogenesis. With the development of innovative technologies, an increasing number of novel ncRNAs have been uncovered; information about their prominent tissue-specific expression patterns, various interaction networks, and subcellular locations will undoubtedly enhance our understanding of their potential functions. Here, we summarized the principles and innovative methods for identifications of novel ncRNAs that have potential functional roles in cancer biology. Moreover, this review also provides alternative ncRNA databases based on high-throughput sequencing or experimental validation, and it briefly describes the current strategy for the clinical translation of cancer-associated ncRNAs to be used in diagnosis.
Abstract Noncoding RNAs (ncRNAs) are a large segment of the transcriptome that do not have apparent protein-coding roles, but they have been verified to play important roles in diverse biological processes, including disease pathogenesis. With the development of innovative technologies, an increasing number of novel ncRNAs have been uncovered; information about their prominent tissue-specific expression patterns, various interaction networks, and subcellular locations will undoubtedly enhance our understanding of their potential functions. Here, we summarized the principles and innovative methods for identifications of novel ncRNAs that have potential functional roles in cancer biology. Moreover, this review also provides alternative ncRNA databases based on high-throughput sequencing or experimental validation, and it briefly describes the current strategy for the clinical translation of cancer-associated ncRNAs to be used in diagnosis.
Noncoding RNAs (ncRNAs) are a large segment of the transcriptome that do not have apparent protein-coding roles, but they have been verified to play important roles in diverse biological processes, including disease pathogenesis. With the development of innovative technologies, an increasing number of novel ncRNAs have been uncovered; information about their prominent tissue-specific expression patterns, various interaction networks, and subcellular locations will undoubtedly enhance our understanding of their potential functions. Here, we summarized the principles and innovative methods for identifications of novel ncRNAs that have potential functional roles in cancer biology. Moreover, this review also provides alternative ncRNA databases based on high-throughput sequencing or experimental validation, and it briefly describes the current strategy for the clinical translation of cancer-associated ncRNAs to be used in diagnosis. Keywords: Novel ncRNAs, Sequencing technologies, Functional ncRNA discovery, Subcellular localization, ncRNA database, Diagnostic kits
Noncoding RNAs (ncRNAs) are a large segment of the transcriptome that do not have apparent protein-coding roles, but they have been verified to play important roles in diverse biological processes, including disease pathogenesis. With the development of innovative technologies, an increasing number of novel ncRNAs have been uncovered; information about their prominent tissue-specific expression patterns, various interaction networks, and subcellular locations will undoubtedly enhance our understanding of their potential functions. Here, we summarized the principles and innovative methods for identifications of novel ncRNAs that have potential functional roles in cancer biology. Moreover, this review also provides alternative ncRNA databases based on high-throughput sequencing or experimental validation, and it briefly describes the current strategy for the clinical translation of cancer-associated ncRNAs to be used in diagnosis.Noncoding RNAs (ncRNAs) are a large segment of the transcriptome that do not have apparent protein-coding roles, but they have been verified to play important roles in diverse biological processes, including disease pathogenesis. With the development of innovative technologies, an increasing number of novel ncRNAs have been uncovered; information about their prominent tissue-specific expression patterns, various interaction networks, and subcellular locations will undoubtedly enhance our understanding of their potential functions. Here, we summarized the principles and innovative methods for identifications of novel ncRNAs that have potential functional roles in cancer biology. Moreover, this review also provides alternative ncRNA databases based on high-throughput sequencing or experimental validation, and it briefly describes the current strategy for the clinical translation of cancer-associated ncRNAs to be used in diagnosis.
ArticleNumber 109
Audience Academic
Author Chen, Yue-Qin
Sun, Yu-Meng
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IsDoiOpenAccess true
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Issue 1
Keywords ncRNA database
Sequencing technologies
Diagnostic kits
Functional ncRNA discovery
Subcellular localization
Novel ncRNAs
Language English
License Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
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Snippet Noncoding RNAs (ncRNAs) are a large segment of the transcriptome that do not have apparent protein-coding roles, but they have been verified to play important...
Abstract Noncoding RNAs (ncRNAs) are a large segment of the transcriptome that do not have apparent protein-coding roles, but they have been verified to play...
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SubjectTerms Cancer
Chromatin - genetics
Classification
Databases, Genetic
Diagnostic kits
Functional ncRNA discovery
Gene expression
Gene Expression Regulation
Genes
Genomes
Health aspects
Hematology
High-Throughput Nucleotide Sequencing
Humans
Identification
Identification and classification
Mammals
Methods
Microarray Analysis
Models, Genetic
ncRNA database
Neoplasms - genetics
Neoplasms - metabolism
Next-generation sequencing
Non-coding RNA
Novel ncRNAs
Oncology
Open Reading Frames - genetics
Organ Specificity
Principles
Protein Biosynthesis
Proteins
Review
Ribosomes - metabolism
RNA
RNA sequencing
RNA, Neoplasm - genetics
RNA, Neoplasm - physiology
RNA, Untranslated - classification
RNA, Untranslated - genetics
RNA, Untranslated - isolation & purification
RNA, Untranslated - physiology
RNA-Seq
Sequencing technologies
Single-Cell Analysis
Structure
Subcellular Fractions - chemistry
Subcellular localization
Transcription, Genetic
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Title Principles and innovative technologies for decrypting noncoding RNAs: from discovery and functional prediction to clinical application
URI https://www.ncbi.nlm.nih.gov/pubmed/32778133
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Volume 13
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