Co-administration of berberine and plant stanols synergistically reduces plasma cholesterol in rats

• Published in: Atherosclerosis Vol. 201; no. 1; pp. 101 - 107
• Main Authors: Jia, Xiaoming, Chen, Yanfeng, Zidichouski, Jeffrey, Zhang, Junzeng, Sun, Changhao, Wang, Yanwen
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ireland Ltd 01.11.2008; Elsevier
• Subjects: Administration, Oral; Animals; Anticholesteremic Agents - administration & dosage; Atherosclerosis (general aspects, experimental research); Berberine; Berberine - administration & dosage; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular; Cholesterol - blood; Coronary heart disease; Diet, Atherogenic; Drug Therapy, Combination; Heart; Lipoproteins - blood; Liver cholesterol; Male; Medical sciences; Phytosterols - administration & dosage; Plant stanols; Plasma cholesterol; Plasma triacylglyceride; Rats; Rats, Sprague-Dawley; Sitosterols - administration & dosage; Toxicity; Triglycerides - blood; triacylglycerides; PS; LDL-C; Toxicity; HDL-cholesterol; T-C; acetyl-CoA carboxylase; AMP-activated protein kinase; berberine chloride; total cholesterol; Plasma triacylglyceride; body weight; HDL-C; LDL-cholesterol; BBR; BBRPS; BW; non-HDL-C; Liver cholesterol; ACC; Berberine; Plasma cholesterol; non-HDL-cholesterol (VLDL-cholesterol + intermediate density lipoprotein cholesterol + LDL-cholesterol); Rats; combination of BBR and plant stanols; control; CT; AMPK; TAG; plant stanols; Plant stanols; Rat; Digestive system; Liver; Rodentia; Lipids; Cardiovascular disease; Cholesterol; Vascular disease; Vertebrata; Mammalia; Animal; Atherosclerosis

Abstract The objective of the present study was to determine the beneficial effects and the safety of oral administration of the combination of berberine (BBR) and plant stanols (PS) on plasma lipid profiles in male Sprague–Dawley rats. Four groups of animals were fed a cornstarch–casein–sucrose-bas...