Co-administration of berberine and plant stanols synergistically reduces plasma cholesterol in rats
Abstract The objective of the present study was to determine the beneficial effects and the safety of oral administration of the combination of berberine (BBR) and plant stanols (PS) on plasma lipid profiles in male Sprague–Dawley rats. Four groups of animals were fed a cornstarch–casein–sucrose-bas...
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Published in | Atherosclerosis Vol. 201; no. 1; pp. 101 - 107 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Amsterdam
Elsevier Ireland Ltd
01.11.2008
Elsevier |
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Abstract | Abstract The objective of the present study was to determine the beneficial effects and the safety of oral administration of the combination of berberine (BBR) and plant stanols (PS) on plasma lipid profiles in male Sprague–Dawley rats. Four groups of animals were fed a cornstarch–casein–sucrose-based high-cholesterol (2%, w:w) and high-fat (27.5%) diet. Three treatment groups were supplemented with either BBR (100 mg kg−1 body weight d−1 ), PS (1% in diet, w:w), or the combination of both (BBRPS). After 6 wk, animals were sacrificed and followed immediately with the collection of blood and organ samples. Lipid analysis revealed that PS lowered plasma total cholesterol (T-C) by 18% ( p = 0.067) and non-HDL-cholesterol (non-HDL-C) by 29% ( p = 0.013) as compared with the control, while BBR had no effect on both T-C and non-HDL-C. The combination treatment of BBRPS reduced plasma T-C by 41% ( p = 0.0002) and non-HDL-C by 59% ( p < 0.0001) compared to the control group. BBR reduced plasma TG levels by 31% at a marginal significance relative to the control ( p = 0.054), whereas PS had no effect. BBRPS showed an additive effect of BBR and PS on plasma TAG. PS and BBRPS both decreased liver cholesterol ( p = 0.0027 and 0.0002, respectively). BBR and PS, either alone or in combination, did not show any toxic effects as assessed by plasma concentration of hepatic biochemical parameters. These results demonstrate that BBR and PS, when combined, synergistically lower plasma cholesterol levels and significantly reduce liver cholesterol, without the observation of any toxic effects. |
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AbstractList | The objective of the present study was to determine the beneficial effects and the safety of oral administration of the combination of berberine (BBR) and plant stanols (PS) on plasma lipid profiles in male Sprague–Dawley rats. Four groups of animals were fed a cornstarch–casein–sucrose-based high-cholesterol (2%, w:w) and high-fat (27.5%) diet. Three treatment groups were supplemented with either BBR (100
mg
kg
−1
body
weight
d
−1), PS (1% in diet, w:w), or the combination of both (BBRPS). After 6 wk, animals were sacrificed and followed immediately with the collection of blood and organ samples. Lipid analysis revealed that PS lowered plasma total cholesterol (T-C) by 18% (
p
=
0.067) and non-HDL-cholesterol (non-HDL-C) by 29% (
p
=
0.013) as compared with the control, while BBR had no effect on both T-C and non-HDL-C. The combination treatment of BBRPS reduced plasma T-C by 41% (
p
=
0.0002) and non-HDL-C by 59% (
p
<
0.0001) compared to the control group. BBR reduced plasma TG levels by 31% at a marginal significance relative to the control (
p
=
0.054), whereas PS had no effect. BBRPS showed an additive effect of BBR and PS on plasma TAG. PS and BBRPS both decreased liver cholesterol (
p
=
0.0027 and 0.0002, respectively). BBR and PS, either alone or in combination, did not show any toxic effects as assessed by plasma concentration of hepatic biochemical parameters. These results demonstrate that BBR and PS, when combined, synergistically lower plasma cholesterol levels and significantly reduce liver cholesterol, without the observation of any toxic effects. The objective of the present study was to determine the beneficial effects and the safety of oral administration of the combination of berberine (BBR) and plant stanols (PS) on plasma lipid profiles in male Sprague-Dawley rats. Four groups of animals were fed a cornstarch-casein-sucrose-based high-cholesterol (2%, w:w) and high-fat (27.5%) diet. Three treatment groups were supplemented with either BBR (100mgkg(-1)bodyweightd(-1)), PS (1% in diet, w:w), or the combination of both (BBRPS). After 6 wk, animals were sacrificed and followed immediately with the collection of blood and organ samples. Lipid analysis revealed that PS lowered plasma total cholesterol (T-C) by 18% (p=0.067) and non-HDL-cholesterol (non-HDL-C) by 29% (p=0.013) as compared with the control, while BBR had no effect on both T-C and non-HDL-C. The combination treatment of BBRPS reduced plasma T-C by 41% (p=0.0002) and non-HDL-C by 59% (p<0.0001) compared to the control group. BBR reduced plasma TG levels by 31% at a marginal significance relative to the control (p=0.054), whereas PS had no effect. BBRPS showed an additive effect of BBR and PS on plasma TAG. PS and BBRPS both decreased liver cholesterol (p=0.0027 and 0.0002, respectively). BBR and PS, either alone or in combination, did not show any toxic effects as assessed by plasma concentration of hepatic biochemical parameters. These results demonstrate that BBR and PS, when combined, synergistically lower plasma cholesterol levels and significantly reduce liver cholesterol, without the observation of any toxic effects. Abstract The objective of the present study was to determine the beneficial effects and the safety of oral administration of the combination of berberine (BBR) and plant stanols (PS) on plasma lipid profiles in male Sprague–Dawley rats. Four groups of animals were fed a cornstarch–casein–sucrose-based high-cholesterol (2%, w:w) and high-fat (27.5%) diet. Three treatment groups were supplemented with either BBR (100 mg kg−1 body weight d−1 ), PS (1% in diet, w:w), or the combination of both (BBRPS). After 6 wk, animals were sacrificed and followed immediately with the collection of blood and organ samples. Lipid analysis revealed that PS lowered plasma total cholesterol (T-C) by 18% ( p = 0.067) and non-HDL-cholesterol (non-HDL-C) by 29% ( p = 0.013) as compared with the control, while BBR had no effect on both T-C and non-HDL-C. The combination treatment of BBRPS reduced plasma T-C by 41% ( p = 0.0002) and non-HDL-C by 59% ( p < 0.0001) compared to the control group. BBR reduced plasma TG levels by 31% at a marginal significance relative to the control ( p = 0.054), whereas PS had no effect. BBRPS showed an additive effect of BBR and PS on plasma TAG. PS and BBRPS both decreased liver cholesterol ( p = 0.0027 and 0.0002, respectively). BBR and PS, either alone or in combination, did not show any toxic effects as assessed by plasma concentration of hepatic biochemical parameters. These results demonstrate that BBR and PS, when combined, synergistically lower plasma cholesterol levels and significantly reduce liver cholesterol, without the observation of any toxic effects. |
Author | Sun, Changhao Wang, Yanwen Chen, Yanfeng Zidichouski, Jeffrey Jia, Xiaoming Zhang, Junzeng |
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Cites_doi | 10.1038/sj.ejcn.1600728 10.1016/j.jep.2006.04.019 10.1093/ajcn/81.6.1351 10.1016/S0025-6196(11)63144-3 10.1042/BST0321051 10.1093/jn/132.7.1983 10.1096/fj.07-9574LSF 10.1007/s11883-007-0006-7 10.1002/mnfr.200600164 10.1186/1476-511X-6-11 10.1016/S0022-2275(20)32378-6 10.1194/jlr.M600020-JLR200 10.1016/S0006-2952(02)00982-6 10.1038/sj.ejcn.1602249 10.1016/S0378-8741(98)00162-7 10.7326/0003-4819-74-1-1 10.1016/S0026-0495(99)90053-7 10.1016/S0002-9149(98)00033-2 10.1093/clinchem/18.6.499 10.1016/j.atherosclerosis.2005.11.012 10.1093/clinchem/28.6.1379 10.1093/ajcn/65.5.1590S 10.2174/1568016043477323 10.1016/0163-7827(93)90002-E 10.1016/0006-2952(95)00262-X 10.1093/ajcn/71.5.1095 10.1016/S0140-6736(86)90597-0 10.2337/db06-0006 10.1016/S0009-8981(97)00163-0 10.1139/y97-011 10.1016/j.atherosclerosis.2005.12.010 10.1517/14656566.4.11.1901 10.1016/0021-9150(95)05624-6 10.1016/S0002-9149(01)01448-5 10.1093/ajcn/70.5.826 10.1161/01.ATV.0000181761.16341.2b 10.1016/S0021-9150(98)00300-1 10.1159/000177875 10.1016/j.jnutbio.2004.12.013 10.1038/nm1135 10.1002/hep.1840110425 10.1097/01.mol.0000199815.46720.ca 10.1254/jjp.59.159 10.1093/ajcn/76.6.1272 10.1093/ajcn/69.3.403 10.1007/s11745-003-1047-3 10.1139/y98-093 10.1097/00041433-200402000-00008 10.1038/emm.2006.71 10.1016/j.clinthera.2007.01.015 10.1073/pnas.231490498 10.1056/NEJM199302043280504 10.1038/sj.ejcn.1600559 10.1046/j.1365-2567.2003.01673.x 10.1093/ajcn/80.5.1159 10.1093/jn/135.11.2499 10.1093/jn/123.11.1939 10.1016/j.jada.2004.10.024 10.1194/jlr.M600195-JLR200 10.1093/ajcn/69.6.1144 10.1016/j.atherosclerosis.2003.12.015 10.1038/sj.ejcn.1602362 |
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Keywords | triacylglycerides PS LDL-C Toxicity HDL-cholesterol T-C acetyl-CoA carboxylase AMP-activated protein kinase berberine chloride total cholesterol Plasma triacylglyceride body weight HDL-C LDL-cholesterol BBR BBRPS BW non-HDL-C Liver cholesterol ACC Berberine Plasma cholesterol non-HDL-cholesterol (VLDL-cholesterol + intermediate density lipoprotein cholesterol + LDL-cholesterol) Rats combination of BBR and plant stanols control CT AMPK TAG plant stanols Plant stanols Rat Digestive system Liver Rodentia Lipids Cardiovascular disease Cholesterol Vascular disease Vertebrata Mammalia Animal Atherosclerosis |
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References | Ezetimibe: new preparation. A cholesterol-lowering drug with no clinical advantage. Prescrire Int 2004;13:176–9. Jones, Ntanios, Raeini-Sarjaz, Vanstone (bib30) 1999; 69 Ostlund, Spilburg, Stenson (bib25) 1999; 70 Kannel, Castelli, Gordon, McNamara (bib2) 1971; 74 Bays, Stein (bib1) 2003; 4 Weststrate, Meijer (bib34) 1998; 52 Friedewald, Levy, Fredrickson (bib39) 1972; 18 Brusq, Ancellin, Grondin (bib52) 2006; 47 Fukuda, Hibiya, Mutoh (bib64) 1999; 66 Magalhaes (bib18) 2005; 85 Gylling, Miettinen (bib33) 1999; 48 Ostlund (bib68) 2004; 15 Hallikainen, Uusitupa (bib29) 1999; 69 Leng, Lu, Xu (bib43) 2004; 25 Abidi, Zhou, Jiang, Liu (bib27) 2005; 25 Van Hoof, Deng, De Broe (bib59) 1997; 266 Wang, Jones, Ausman, Lichtenstein (bib40) 2004; 173 Hendriks, Weststrate, van Vliet, Meijer (bib28) 1999; 53 Kris-Etherton, Dietschy (bib45) 1997; 65 Lee, Kim, Kim (bib51) 2006; 55 Buse, Klonoff, Nielsen (bib60) 2007; 29 Ling, Jones (bib55) 1995; 118 Thompson (bib19) 1999; 1 Normen, Shaw, Fink, Awad (bib32) 2004; 2 Varady, Ebine, Vanstone, Parsons, Jones (bib20) 2004; 80 Wang, Jones, Pischel, Fairow (bib57) 2003; 38 Lau, Journoud, Jones (bib56) 2005; 81 Rodenburg, Vissers, Daniels, Wiegman, Kastelein (bib14) 2004; 2 Warnick, Benderson, Albers (bib38) 1982; 28 Hayes, Pronczuk, Wijendran, Beer (bib48) 2002; 132 Merkel, Velez-Carrasco, Hudgins, Breslow (bib4) 2001; 98 Grundy (bib11) 1998; 81 Reeves, Nielsen, Fahey (bib70) 1993; 123 Suckling, Jackson (bib44) 1993; 32 Arrese, Pizarro, Solis, Koenig, Accatino (bib61) 1995; 50 Kang, Chung, Cho, Kim (bib63) 2002; 63 Korpela, Tuomilehto, Hogstrom (bib21) 2006; 60 Hallikainen, Lyyra-Laitinen, Laitinen (bib37) 2005; 188 Jones, MacDougall, Ntanios, Vanstone (bib54) 1997; 75 Kim, Kang, Cho, Kim (bib62) 2003; 109 Bradford, Awad (bib65) 2007; 51 Abidi, Chen, Kraemer, Li, Liu (bib26) 2006; 47 Pelletier, Belbraouet, Mirabel (bib36) 1995; 39 Reagan-Shaw, Nihal, Ahmad (bib69) 2008; 22 Le, Walter (bib10) 2007; 9 Ntanios, MacDougall, Jones (bib67) 1998; 76 Kong, Wei, Abidi (bib13) 2004; 10 Ellegard, Andersson, Bosaeus (bib49) 2005; 59 Vanstone, Raeini-Sarjaz, Parsons, Jones (bib12) 2002; 76 Chan, Barrett, Watts (bib3) 2006; 17 Kidd (bib66) 2003; 8 Martin, Hulley, Browner, Kuller, Wentworth (bib5) 1986; 2 Shepherd (bib15) 2004; 32 Jones, Raeini-Sarjaz, Ntanios (bib23) 2000; 41 Ren, Vasil’ev, Orkehov, Tertov, Tutel’ian (bib41) 1989; 52 Bergen, Mersmann (bib46) 2005; 135 Jeppesen, Hansen, Rasmussen, Ibsen, Torp-Pedersen (bib7) 2006; 189 Patch, Tapsell, Williams (bib35) 2005; 105 Hattori, Furuta, Nagao (bib42) 1992; 59 Gores, Herman, Lemasters (bib58) 1990; 11 Klag, Ford, Mead (bib6) 1993; 328 Hayes, Pronczuk, Wijendran, Beer (bib50) 2005; 16 Egger, Smith, Pfluger, Altpeter, Elwood (bib8) 1999; 143 Miettinen, Vuoristo, Nissinen, Jarvinen, Gylling (bib24) 2000; 71 Rutishauser (bib16) 2006; 136 Choi, Ahn, Kim (bib53) 2006; 38 Assmann (bib9) 2001; 87 Acuff, Cai, Dong, Bell (bib22) 2007; 6 Katan, Grundy, Jones (bib31) 2003; 78 Tang, Wei, Chen, Liu (bib47) 2006; 108 Ren (10.1016/j.atherosclerosis.2008.03.008_bib41) 1989; 52 Choi (10.1016/j.atherosclerosis.2008.03.008_bib53) 2006; 38 Le (10.1016/j.atherosclerosis.2008.03.008_bib10) 2007; 9 Jones (10.1016/j.atherosclerosis.2008.03.008_bib30) 1999; 69 Rodenburg (10.1016/j.atherosclerosis.2008.03.008_bib14) 2004; 2 Hallikainen (10.1016/j.atherosclerosis.2008.03.008_bib37) 2005; 188 Buse (10.1016/j.atherosclerosis.2008.03.008_bib60) 2007; 29 Kidd (10.1016/j.atherosclerosis.2008.03.008_bib66) 2003; 8 Merkel (10.1016/j.atherosclerosis.2008.03.008_bib4) 2001; 98 Kang (10.1016/j.atherosclerosis.2008.03.008_bib63) 2002; 63 Varady (10.1016/j.atherosclerosis.2008.03.008_bib20) 2004; 80 Vanstone (10.1016/j.atherosclerosis.2008.03.008_bib12) 2002; 76 Rutishauser (10.1016/j.atherosclerosis.2008.03.008_bib16) 2006; 136 Grundy (10.1016/j.atherosclerosis.2008.03.008_bib11) 1998; 81 Jones (10.1016/j.atherosclerosis.2008.03.008_bib54) 1997; 75 Jeppesen (10.1016/j.atherosclerosis.2008.03.008_bib7) 2006; 189 Pelletier (10.1016/j.atherosclerosis.2008.03.008_bib36) 1995; 39 Hattori (10.1016/j.atherosclerosis.2008.03.008_bib42) 1992; 59 Normen (10.1016/j.atherosclerosis.2008.03.008_bib32) 2004; 2 Wang (10.1016/j.atherosclerosis.2008.03.008_bib57) 2003; 38 Gylling (10.1016/j.atherosclerosis.2008.03.008_bib33) 1999; 48 Egger (10.1016/j.atherosclerosis.2008.03.008_bib8) 1999; 143 Weststrate (10.1016/j.atherosclerosis.2008.03.008_bib34) 1998; 52 Kong (10.1016/j.atherosclerosis.2008.03.008_bib13) 2004; 10 Hayes (10.1016/j.atherosclerosis.2008.03.008_bib48) 2002; 132 Acuff (10.1016/j.atherosclerosis.2008.03.008_bib22) 2007; 6 Van Hoof (10.1016/j.atherosclerosis.2008.03.008_bib59) 1997; 266 Friedewald (10.1016/j.atherosclerosis.2008.03.008_bib39) 1972; 18 Klag (10.1016/j.atherosclerosis.2008.03.008_bib6) 1993; 328 Ling (10.1016/j.atherosclerosis.2008.03.008_bib55) 1995; 118 Hallikainen (10.1016/j.atherosclerosis.2008.03.008_bib29) 1999; 69 Gores (10.1016/j.atherosclerosis.2008.03.008_bib58) 1990; 11 Katan (10.1016/j.atherosclerosis.2008.03.008_bib31) 2003; 78 Reagan-Shaw (10.1016/j.atherosclerosis.2008.03.008_bib69) 2008; 22 Chan (10.1016/j.atherosclerosis.2008.03.008_bib3) 2006; 17 Korpela (10.1016/j.atherosclerosis.2008.03.008_bib21) 2006; 60 Miettinen (10.1016/j.atherosclerosis.2008.03.008_bib24) 2000; 71 Assmann (10.1016/j.atherosclerosis.2008.03.008_bib9) 2001; 87 Shepherd (10.1016/j.atherosclerosis.2008.03.008_bib15) 2004; 32 Ostlund (10.1016/j.atherosclerosis.2008.03.008_bib25) 1999; 70 Reeves (10.1016/j.atherosclerosis.2008.03.008_bib70) 1993; 123 Martin (10.1016/j.atherosclerosis.2008.03.008_bib5) 1986; 2 Abidi (10.1016/j.atherosclerosis.2008.03.008_bib27) 2005; 25 Ntanios (10.1016/j.atherosclerosis.2008.03.008_bib67) 1998; 76 Kris-Etherton (10.1016/j.atherosclerosis.2008.03.008_bib45) 1997; 65 Fukuda (10.1016/j.atherosclerosis.2008.03.008_bib64) 1999; 66 Suckling (10.1016/j.atherosclerosis.2008.03.008_bib44) 1993; 32 Kannel (10.1016/j.atherosclerosis.2008.03.008_bib2) 1971; 74 Hayes (10.1016/j.atherosclerosis.2008.03.008_bib50) 2005; 16 Arrese (10.1016/j.atherosclerosis.2008.03.008_bib61) 1995; 50 Patch (10.1016/j.atherosclerosis.2008.03.008_bib35) 2005; 105 Bradford (10.1016/j.atherosclerosis.2008.03.008_bib65) 2007; 51 Jones (10.1016/j.atherosclerosis.2008.03.008_bib23) 2000; 41 Tang (10.1016/j.atherosclerosis.2008.03.008_bib47) 2006; 108 Hendriks (10.1016/j.atherosclerosis.2008.03.008_bib28) 1999; 53 Bergen (10.1016/j.atherosclerosis.2008.03.008_bib46) 2005; 135 Abidi (10.1016/j.atherosclerosis.2008.03.008_bib26) 2006; 47 10.1016/j.atherosclerosis.2008.03.008_bib17 Magalhaes (10.1016/j.atherosclerosis.2008.03.008_bib18) 2005; 85 Leng (10.1016/j.atherosclerosis.2008.03.008_bib43) 2004; 25 Kim (10.1016/j.atherosclerosis.2008.03.008_bib62) 2003; 109 Ostlund (10.1016/j.atherosclerosis.2008.03.008_bib68) 2004; 15 Brusq (10.1016/j.atherosclerosis.2008.03.008_bib52) 2006; 47 Ellegard (10.1016/j.atherosclerosis.2008.03.008_bib49) 2005; 59 Lee (10.1016/j.atherosclerosis.2008.03.008_bib51) 2006; 55 Thompson (10.1016/j.atherosclerosis.2008.03.008_bib19) 1999; 1 Warnick (10.1016/j.atherosclerosis.2008.03.008_bib38) 1982; 28 Wang (10.1016/j.atherosclerosis.2008.03.008_bib40) 2004; 173 Bays (10.1016/j.atherosclerosis.2008.03.008_bib1) 2003; 4 Lau (10.1016/j.atherosclerosis.2008.03.008_bib56) 2005; 81 |
References_xml | – volume: 59 start-page: 159 year: 1992 end-page: 169 ident: bib42 article-title: Studies on the antinephritic effect of plant components. (4). Reduction of protein excretion by berberine and coptisine in rats with original-type anti-GBM nephritis publication-title: Jpn J Pharmacol contributor: fullname: Nagao – volume: 38 start-page: 165 year: 2003 end-page: 170 ident: bib57 article-title: Effects of policosanols and phytosterols on lipid levels and cholesterol biosynthesis in hamsters publication-title: Lipids contributor: fullname: Fairow – volume: 108 start-page: 109 year: 2006 end-page: 115 ident: bib47 article-title: Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats publication-title: J Ethnopharmacol contributor: fullname: Liu – volume: 63 start-page: 1901 year: 2002 end-page: 1910 ident: bib63 article-title: Involvement of p38 mitogen-activated protein kinase in the induction of interleukin-12 p40 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid publication-title: Biochem Pharmacol contributor: fullname: Kim – volume: 25 start-page: 2170 year: 2005 end-page: 2176 ident: bib27 article-title: Extracellular signal-regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine publication-title: Arterioscler Thromb Vasc Biol contributor: fullname: Liu – volume: 28 start-page: 1379 year: 1982 end-page: 1388 ident: bib38 article-title: Dextran sulfate-Mg publication-title: Clin Chem contributor: fullname: Albers – volume: 38 start-page: 599 year: 2006 end-page: 605 ident: bib53 article-title: Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte publication-title: Exp Mol Med contributor: fullname: Kim – volume: 51 start-page: 161 year: 2007 end-page: 170 ident: bib65 article-title: Phytosterols as anticancer compounds publication-title: Mol Nutr Food Res contributor: fullname: Awad – volume: 32 start-page: 1051 year: 2004 end-page: 1056 ident: bib15 article-title: Lipids in health and disease publication-title: Biochem Soc Trans contributor: fullname: Shepherd – volume: 81 start-page: 18B year: 1998 end-page: 25B ident: bib11 article-title: Hypertriglyceridemia, atherogenic dyslipidemia, and the metabolic syndrome publication-title: Am J Cardiol contributor: fullname: Grundy – volume: 2 start-page: 1 year: 2004 end-page: 12 ident: bib32 article-title: Combination of phytosterols and omega-3 fatty acids: a potential strategy to promote cardiovascular health publication-title: Curr Med Chem Cardiovasc Hematol Agents contributor: fullname: Awad – volume: 105 start-page: 46 year: 2005 end-page: 52 ident: bib35 article-title: Plant sterol/stanol prescription is an effective treatment strategy for managing hypercholesterolemia in outpatient clinical practice publication-title: J Am Diet Assoc contributor: fullname: Williams – volume: 55 start-page: 2256 year: 2006 end-page: 2264 ident: bib51 article-title: Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states publication-title: Diabetes contributor: fullname: Kim – volume: 69 start-page: 403 year: 1999 end-page: 410 ident: bib29 article-title: Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic subjects publication-title: Am J Clin Nutr contributor: fullname: Uusitupa – volume: 80 start-page: 1159 year: 2004 end-page: 1166 ident: bib20 article-title: Plant sterols and endurance training combine to favorably alter plasma lipid profiles in previously sedentary hypercholesterolemic adults after 8 publication-title: Am J Clin Nutr contributor: fullname: Jones – volume: 143 start-page: 275 year: 1999 end-page: 284 ident: bib8 article-title: Triglyceride as a risk factor for ischaemic heart disease in British men: effect of adjusting for measurement error publication-title: Atherosclerosis contributor: fullname: Elwood – volume: 29 start-page: 139 year: 2007 end-page: 153 ident: bib60 article-title: Metabolic effects of two years of exenatide treatment on diabetes, obesity, and hepatic biomarkers in patients with type 2 diabetes: an interim analysis of data from the open-label, uncontrolled extension of three double-blind, placebo-controlled trials publication-title: Clin Ther contributor: fullname: Nielsen – volume: 189 start-page: 369 year: 2006 end-page: 374 ident: bib7 article-title: Metabolic syndrome, low-density lipoprotein cholesterol, and risk of cardiovascular disease: a population-based study publication-title: Atherosclerosis contributor: fullname: Torp-Pedersen – volume: 25 start-page: 496 year: 2004 end-page: 502 ident: bib43 article-title: Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion publication-title: Acta Pharmacol Sin contributor: fullname: Xu – volume: 87 start-page: 2B year: 2001 end-page: 7B ident: bib9 article-title: Pro and con: high-density lipoprotein, triglycerides, and other lipid subfractions are the future of lipid management publication-title: Am J Cardiol contributor: fullname: Assmann – volume: 18 start-page: 499 year: 1972 end-page: 502 ident: bib39 article-title: Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge publication-title: Clin Chem contributor: fullname: Fredrickson – volume: 123 start-page: 1939 year: 1993 end-page: 1951 ident: bib70 article-title: AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet publication-title: J Nutr contributor: fullname: Fahey – volume: 76 start-page: 780 year: 1998 end-page: 787 ident: bib67 article-title: Gender effects of tall oil versus soybean phytosterols as cholesterol-lowering agents in hamsters publication-title: Can J Physiol Pharmacol contributor: fullname: Jones – volume: 266 start-page: 23 year: 1997 end-page: 31 ident: bib59 article-title: How do plasma membranes reach the circulation? publication-title: Clin Chim Acta contributor: fullname: De Broe – volume: 136 start-page: 41 year: 2006 end-page: 49 ident: bib16 article-title: The role of statins in clinical medicine—LDL-cholesterol lowering and beyond publication-title: Swiss Med Wkly contributor: fullname: Rutishauser – volume: 2 start-page: 171 year: 2004 end-page: 180 ident: bib14 article-title: Lipid-lowering medications publication-title: Pediatr Endocrinol Rev contributor: fullname: Kastelein – volume: 2 start-page: 933 year: 1986 end-page: 936 ident: bib5 article-title: Serum cholesterol, blood pressure, and mortality: implications from a cohort of 361,662 men publication-title: Lancet contributor: fullname: Wentworth – volume: 52 start-page: 334 year: 1998 end-page: 343 ident: bib34 article-title: Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects publication-title: Eur J Clin Nutr contributor: fullname: Meijer – volume: 109 start-page: 407 year: 2003 end-page: 414 ident: bib62 article-title: Induction of interleukin-12 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid, deviates CD4+ T cells from a Th2 to a Th1 response publication-title: Immunology contributor: fullname: Kim – volume: 39 start-page: 291 year: 1995 end-page: 295 ident: bib36 article-title: A diet moderately enriched in phytosterols lowers plasma cholesterol concentrations in normocholesterolemic humans publication-title: Ann Nutr Metab contributor: fullname: Mirabel – volume: 70 start-page: 826 year: 1999 end-page: 831 ident: bib25 article-title: Sitostanol administered in lecithin micelles potently reduces cholesterol absorption in humans publication-title: Am J Clin Nutr contributor: fullname: Stenson – volume: 173 start-page: 269 year: 2004 end-page: 275 ident: bib40 article-title: Soy protein reduces triglyceride levels and triglyceride fatty acid fractional synthesis rate in hypercholesterolemic subjects publication-title: Atherosclerosis contributor: fullname: Lichtenstein – volume: 50 start-page: 1223 year: 1995 end-page: 1232 ident: bib61 article-title: Enhanced biliary excretion of canalicular membrane enzymes in ethynylestradiol-induced cholestasis. Effects of ursodeoxycholic acid administration publication-title: Biochem Pharmacol contributor: fullname: Accatino – volume: 10 start-page: 1344 year: 2004 end-page: 1351 ident: bib13 article-title: Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins publication-title: Nat Med contributor: fullname: Abidi – volume: 47 start-page: 2134 year: 2006 end-page: 2147 ident: bib26 article-title: The medicinal plant goldenseal is a natural LDL-lowering agent with multiple bioactive components and new action mechanisms publication-title: J Lipid Res contributor: fullname: Liu – volume: 16 start-page: 305 year: 2005 end-page: 311 ident: bib50 article-title: Free phytosterols facilitate excretion of endogenous cholesterol in gerbils publication-title: J Nutr Biochem contributor: fullname: Beer – volume: 8 start-page: 223 year: 2003 end-page: 246 ident: bib66 article-title: Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease publication-title: Altern Med Rev contributor: fullname: Kidd – volume: 9 start-page: 110 year: 2007 end-page: 115 ident: bib10 article-title: The role of hypertriglyceridemia in atherosclerosis publication-title: Curr Atheroscler Rep contributor: fullname: Walter – volume: 60 start-page: 633 year: 2006 end-page: 642 ident: bib21 article-title: Safety aspects and cholesterol-lowering efficacy of low fat dairy products containing plant sterols publication-title: Eur J Clin Nutr contributor: fullname: Hogstrom – volume: 188 start-page: 425 year: 2005 end-page: 432 ident: bib37 article-title: Endothelial function in hypercholesterolemic subjects: effects of plant stanol and sterol esters publication-title: Atherosclerosis contributor: fullname: Laitinen – volume: 32 start-page: 1 year: 1993 end-page: 24 ident: bib44 article-title: Animal models of human lipid metabolism publication-title: Prog Lipid Res contributor: fullname: Jackson – volume: 76 start-page: 1272 year: 2002 end-page: 1278 ident: bib12 article-title: Unesterified plant sterols and stanols lower LDL-cholesterol concentrations equivalently in hypercholesterolemic persons publication-title: Am J Clin Nutr contributor: fullname: Jones – volume: 135 start-page: 2499 year: 2005 end-page: 2502 ident: bib46 article-title: Comparative aspects of lipid metabolism: impact on contemporary research and use of animal models publication-title: J Nutr contributor: fullname: Mersmann – volume: 1 start-page: S114 year: 1999 end-page: S117 ident: bib19 article-title: Poor responders to statins: a potential target fro stanol esters publication-title: Eur Heart J Suppl contributor: fullname: Thompson – volume: 6 start-page: 11 year: 2007 ident: bib22 article-title: The lipid lowering effect of plant sterol ester capsules in hypercholesterolemic subjects publication-title: Lipids Health Dis contributor: fullname: Bell – volume: 81 start-page: 1351 year: 2005 end-page: 1358 ident: bib56 article-title: Plant sterols are efficacious in lowering plasma LDL and non-HDL cholesterol in hypercholesterolemic type 2 diabetic and nondiabetic persons publication-title: Am J Clin Nutr contributor: fullname: Jones – volume: 41 start-page: 697 year: 2000 end-page: 705 ident: bib23 article-title: Modulation of plasma lipid levels and cholesterol kinetics by phytosterol versus phytostanol esters publication-title: J Lipid Res contributor: fullname: Ntanios – volume: 47 start-page: 1281 year: 2006 end-page: 1288 ident: bib52 article-title: Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine publication-title: J Lipid Res contributor: fullname: Grondin – volume: 85 start-page: 42 year: 2005 end-page: 44 ident: bib18 article-title: Mechanisms of rhabdomyolysis with statins publication-title: Arq Bras Cardiol contributor: fullname: Magalhaes – volume: 69 start-page: 1144 year: 1999 end-page: 1150 ident: bib30 article-title: Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men publication-title: Am J Clin Nutr contributor: fullname: Vanstone – volume: 75 start-page: 217 year: 1997 end-page: 227 ident: bib54 article-title: Dietary phytosterols as cholesterol-lowering agents in humans publication-title: Can J Physiol Pharmacol contributor: fullname: Vanstone – volume: 17 start-page: 28 year: 2006 end-page: 36 ident: bib3 article-title: Recent studies of lipoprotein kinetics in the metabolic syndrome and related disorders publication-title: Curr Opin Lipidol contributor: fullname: Watts – volume: 11 start-page: 690 year: 1990 end-page: 698 ident: bib58 article-title: Plasma membrane bleb formation and rupture: a common feature of hepatocellular injury publication-title: Hepatology contributor: fullname: Lemasters – volume: 59 start-page: 1374 year: 2005 end-page: 1378 ident: bib49 article-title: Rapeseed oil, olive oil, plant sterols, and cholesterol metabolism: an ileostomy study publication-title: Eur J Clin Nutr contributor: fullname: Bosaeus – volume: 53 start-page: 319 year: 1999 end-page: 327 ident: bib28 article-title: Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects publication-title: Eur J Clin Nutr contributor: fullname: Meijer – volume: 15 start-page: 37 year: 2004 end-page: 41 ident: bib68 article-title: Phytosterols and cholesterol metabolism publication-title: Curr Opin Lipidol contributor: fullname: Ostlund – volume: 71 start-page: 1095 year: 2000 end-page: 1102 ident: bib24 article-title: Serum, biliary, and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine publication-title: Am J Clin Nutr contributor: fullname: Gylling – volume: 118 start-page: 319 year: 1995 end-page: 331 ident: bib55 article-title: Enhanced efficacy of sitostanol-containing versus sitostanol-free phytosterol mixtures in altering lipoprotein cholesterol levels and synthesis in rats publication-title: Atherosclerosis contributor: fullname: Jones – volume: 66 start-page: 227 year: 1999 end-page: 233 ident: bib64 article-title: Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells publication-title: J Ethnopharmacol contributor: fullname: Mutoh – volume: 65 start-page: S1590 year: 1997 end-page: S1596 ident: bib45 article-title: Design criteria for studies examining individual fatty acid effects on cardiovascular disease risk factors: human and animal studies publication-title: Am J Clin Nutr contributor: fullname: Dietschy – volume: 98 start-page: 13294 year: 2001 end-page: 13299 ident: bib4 article-title: Compared with saturated fatty acids, dietary monounsaturated fatty acids and carbohydrates increase atherosclerosis and VLDL cholesterol levels in LDL receptor-deficient, but not apolipoprotein E-deficient, mice publication-title: Proc Natl Acad Sci USA contributor: fullname: Breslow – volume: 22 start-page: 659 year: 2008 end-page: 661 ident: bib69 article-title: Dose translation from animal to human studies revisited publication-title: FASEB J contributor: fullname: Ahmad – volume: 74 start-page: 1 year: 1971 end-page: 12 ident: bib2 article-title: Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study publication-title: Ann Intern Med contributor: fullname: McNamara – volume: 78 start-page: 965 year: 2003 end-page: 978 ident: bib31 article-title: Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels publication-title: Mayo Clin Proc contributor: fullname: Jones – volume: 48 start-page: 575 year: 1999 end-page: 580 ident: bib33 article-title: Cholesterol reduction by different plant stanol mixtures and with variable fat intake publication-title: Metabolism contributor: fullname: Miettinen – volume: 52 start-page: 44 year: 1989 end-page: 46 ident: bib41 article-title: Evaluation of the antiatherosclerotic properties of natural compounds of plant origin on cell cultures of the human aortic intima publication-title: Farmakol Toksikol contributor: fullname: Tutel’ian – volume: 132 start-page: 1983 year: 2002 end-page: 1988 ident: bib48 article-title: Free phytosterols effectively reduce plasma and liver cholesterol in gerbils fed cholesterol publication-title: J Nutr contributor: fullname: Beer – volume: 328 start-page: 313 year: 1993 end-page: 318 ident: bib6 article-title: Serum cholesterol in young men and subsequent cardiovascular disease publication-title: N Engl J Med contributor: fullname: Mead – volume: 4 start-page: 1901 year: 2003 end-page: 1938 ident: bib1 article-title: Pharmacotherapy for dyslipidaemia—current therapies and future agents publication-title: Exp Opin Pharmacother contributor: fullname: Stein – volume: 53 start-page: 319 year: 1999 ident: 10.1016/j.atherosclerosis.2008.03.008_bib28 article-title: Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects publication-title: Eur J Clin Nutr doi: 10.1038/sj.ejcn.1600728 contributor: fullname: Hendriks – volume: 108 start-page: 109 year: 2006 ident: 10.1016/j.atherosclerosis.2008.03.008_bib47 article-title: Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats publication-title: J Ethnopharmacol doi: 10.1016/j.jep.2006.04.019 contributor: fullname: Tang – volume: 81 start-page: 1351 year: 2005 ident: 10.1016/j.atherosclerosis.2008.03.008_bib56 article-title: Plant sterols are efficacious in lowering plasma LDL and non-HDL cholesterol in hypercholesterolemic type 2 diabetic and nondiabetic persons publication-title: Am J Clin Nutr doi: 10.1093/ajcn/81.6.1351 contributor: fullname: Lau – volume: 78 start-page: 965 year: 2003 ident: 10.1016/j.atherosclerosis.2008.03.008_bib31 article-title: Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels publication-title: Mayo Clin Proc doi: 10.1016/S0025-6196(11)63144-3 contributor: fullname: Katan – volume: 32 start-page: 1051 year: 2004 ident: 10.1016/j.atherosclerosis.2008.03.008_bib15 article-title: Lipids in health and disease publication-title: Biochem Soc Trans doi: 10.1042/BST0321051 contributor: fullname: Shepherd – volume: 132 start-page: 1983 year: 2002 ident: 10.1016/j.atherosclerosis.2008.03.008_bib48 article-title: Free phytosterols effectively reduce plasma and liver cholesterol in gerbils fed cholesterol publication-title: J Nutr doi: 10.1093/jn/132.7.1983 contributor: fullname: Hayes – volume: 22 start-page: 659 year: 2008 ident: 10.1016/j.atherosclerosis.2008.03.008_bib69 article-title: Dose translation from animal to human studies revisited publication-title: FASEB J doi: 10.1096/fj.07-9574LSF contributor: fullname: Reagan-Shaw – volume: 9 start-page: 110 year: 2007 ident: 10.1016/j.atherosclerosis.2008.03.008_bib10 article-title: The role of hypertriglyceridemia in atherosclerosis publication-title: Curr Atheroscler Rep doi: 10.1007/s11883-007-0006-7 contributor: fullname: Le – volume: 51 start-page: 161 year: 2007 ident: 10.1016/j.atherosclerosis.2008.03.008_bib65 article-title: Phytosterols as anticancer compounds publication-title: Mol Nutr Food Res doi: 10.1002/mnfr.200600164 contributor: fullname: Bradford – volume: 6 start-page: 11 year: 2007 ident: 10.1016/j.atherosclerosis.2008.03.008_bib22 article-title: The lipid lowering effect of plant sterol ester capsules in hypercholesterolemic subjects publication-title: Lipids Health Dis doi: 10.1186/1476-511X-6-11 contributor: fullname: Acuff – volume: 41 start-page: 697 year: 2000 ident: 10.1016/j.atherosclerosis.2008.03.008_bib23 article-title: Modulation of plasma lipid levels and cholesterol kinetics by phytosterol versus phytostanol esters publication-title: J Lipid Res doi: 10.1016/S0022-2275(20)32378-6 contributor: fullname: Jones – ident: 10.1016/j.atherosclerosis.2008.03.008_bib17 – volume: 47 start-page: 1281 year: 2006 ident: 10.1016/j.atherosclerosis.2008.03.008_bib52 article-title: Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine publication-title: J Lipid Res doi: 10.1194/jlr.M600020-JLR200 contributor: fullname: Brusq – volume: 63 start-page: 1901 year: 2002 ident: 10.1016/j.atherosclerosis.2008.03.008_bib63 article-title: Involvement of p38 mitogen-activated protein kinase in the induction of interleukin-12 p40 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid publication-title: Biochem Pharmacol doi: 10.1016/S0006-2952(02)00982-6 contributor: fullname: Kang – volume: 59 start-page: 1374 year: 2005 ident: 10.1016/j.atherosclerosis.2008.03.008_bib49 article-title: Rapeseed oil, olive oil, plant sterols, and cholesterol metabolism: an ileostomy study publication-title: Eur J Clin Nutr doi: 10.1038/sj.ejcn.1602249 contributor: fullname: Ellegard – volume: 66 start-page: 227 year: 1999 ident: 10.1016/j.atherosclerosis.2008.03.008_bib64 article-title: Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells publication-title: J Ethnopharmacol doi: 10.1016/S0378-8741(98)00162-7 contributor: fullname: Fukuda – volume: 74 start-page: 1 year: 1971 ident: 10.1016/j.atherosclerosis.2008.03.008_bib2 article-title: Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study publication-title: Ann Intern Med doi: 10.7326/0003-4819-74-1-1 contributor: fullname: Kannel – volume: 1 start-page: S114 year: 1999 ident: 10.1016/j.atherosclerosis.2008.03.008_bib19 article-title: Poor responders to statins: a potential target fro stanol esters publication-title: Eur Heart J Suppl contributor: fullname: Thompson – volume: 48 start-page: 575 year: 1999 ident: 10.1016/j.atherosclerosis.2008.03.008_bib33 article-title: Cholesterol reduction by different plant stanol mixtures and with variable fat intake publication-title: Metabolism doi: 10.1016/S0026-0495(99)90053-7 contributor: fullname: Gylling – volume: 81 start-page: 18B year: 1998 ident: 10.1016/j.atherosclerosis.2008.03.008_bib11 article-title: Hypertriglyceridemia, atherogenic dyslipidemia, and the metabolic syndrome publication-title: Am J Cardiol doi: 10.1016/S0002-9149(98)00033-2 contributor: fullname: Grundy – volume: 18 start-page: 499 year: 1972 ident: 10.1016/j.atherosclerosis.2008.03.008_bib39 article-title: Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge publication-title: Clin Chem doi: 10.1093/clinchem/18.6.499 contributor: fullname: Friedewald – volume: 188 start-page: 425 year: 2005 ident: 10.1016/j.atherosclerosis.2008.03.008_bib37 article-title: Endothelial function in hypercholesterolemic subjects: effects of plant stanol and sterol esters publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2005.11.012 contributor: fullname: Hallikainen – volume: 28 start-page: 1379 year: 1982 ident: 10.1016/j.atherosclerosis.2008.03.008_bib38 article-title: Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol publication-title: Clin Chem doi: 10.1093/clinchem/28.6.1379 contributor: fullname: Warnick – volume: 65 start-page: S1590 year: 1997 ident: 10.1016/j.atherosclerosis.2008.03.008_bib45 article-title: Design criteria for studies examining individual fatty acid effects on cardiovascular disease risk factors: human and animal studies publication-title: Am J Clin Nutr doi: 10.1093/ajcn/65.5.1590S contributor: fullname: Kris-Etherton – volume: 2 start-page: 1 year: 2004 ident: 10.1016/j.atherosclerosis.2008.03.008_bib32 article-title: Combination of phytosterols and omega-3 fatty acids: a potential strategy to promote cardiovascular health publication-title: Curr Med Chem Cardiovasc Hematol Agents doi: 10.2174/1568016043477323 contributor: fullname: Normen – volume: 32 start-page: 1 year: 1993 ident: 10.1016/j.atherosclerosis.2008.03.008_bib44 article-title: Animal models of human lipid metabolism publication-title: Prog Lipid Res doi: 10.1016/0163-7827(93)90002-E contributor: fullname: Suckling – volume: 50 start-page: 1223 year: 1995 ident: 10.1016/j.atherosclerosis.2008.03.008_bib61 article-title: Enhanced biliary excretion of canalicular membrane enzymes in ethynylestradiol-induced cholestasis. Effects of ursodeoxycholic acid administration publication-title: Biochem Pharmacol doi: 10.1016/0006-2952(95)00262-X contributor: fullname: Arrese – volume: 71 start-page: 1095 year: 2000 ident: 10.1016/j.atherosclerosis.2008.03.008_bib24 article-title: Serum, biliary, and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine publication-title: Am J Clin Nutr doi: 10.1093/ajcn/71.5.1095 contributor: fullname: Miettinen – volume: 2 start-page: 933 year: 1986 ident: 10.1016/j.atherosclerosis.2008.03.008_bib5 article-title: Serum cholesterol, blood pressure, and mortality: implications from a cohort of 361,662 men publication-title: Lancet doi: 10.1016/S0140-6736(86)90597-0 contributor: fullname: Martin – volume: 55 start-page: 2256 year: 2006 ident: 10.1016/j.atherosclerosis.2008.03.008_bib51 article-title: Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states publication-title: Diabetes doi: 10.2337/db06-0006 contributor: fullname: Lee – volume: 266 start-page: 23 year: 1997 ident: 10.1016/j.atherosclerosis.2008.03.008_bib59 article-title: How do plasma membranes reach the circulation? publication-title: Clin Chim Acta doi: 10.1016/S0009-8981(97)00163-0 contributor: fullname: Van Hoof – volume: 8 start-page: 223 year: 2003 ident: 10.1016/j.atherosclerosis.2008.03.008_bib66 article-title: Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease publication-title: Altern Med Rev contributor: fullname: Kidd – volume: 75 start-page: 217 year: 1997 ident: 10.1016/j.atherosclerosis.2008.03.008_bib54 article-title: Dietary phytosterols as cholesterol-lowering agents in humans publication-title: Can J Physiol Pharmacol doi: 10.1139/y97-011 contributor: fullname: Jones – volume: 189 start-page: 369 year: 2006 ident: 10.1016/j.atherosclerosis.2008.03.008_bib7 article-title: Metabolic syndrome, low-density lipoprotein cholesterol, and risk of cardiovascular disease: a population-based study publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2005.12.010 contributor: fullname: Jeppesen – volume: 4 start-page: 1901 year: 2003 ident: 10.1016/j.atherosclerosis.2008.03.008_bib1 article-title: Pharmacotherapy for dyslipidaemia—current therapies and future agents publication-title: Exp Opin Pharmacother doi: 10.1517/14656566.4.11.1901 contributor: fullname: Bays – volume: 25 start-page: 496 year: 2004 ident: 10.1016/j.atherosclerosis.2008.03.008_bib43 article-title: Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion publication-title: Acta Pharmacol Sin contributor: fullname: Leng – volume: 118 start-page: 319 year: 1995 ident: 10.1016/j.atherosclerosis.2008.03.008_bib55 article-title: Enhanced efficacy of sitostanol-containing versus sitostanol-free phytosterol mixtures in altering lipoprotein cholesterol levels and synthesis in rats publication-title: Atherosclerosis doi: 10.1016/0021-9150(95)05624-6 contributor: fullname: Ling – volume: 52 start-page: 44 year: 1989 ident: 10.1016/j.atherosclerosis.2008.03.008_bib41 article-title: Evaluation of the antiatherosclerotic properties of natural compounds of plant origin on cell cultures of the human aortic intima publication-title: Farmakol Toksikol contributor: fullname: Ren – volume: 87 start-page: 2B year: 2001 ident: 10.1016/j.atherosclerosis.2008.03.008_bib9 article-title: Pro and con: high-density lipoprotein, triglycerides, and other lipid subfractions are the future of lipid management publication-title: Am J Cardiol doi: 10.1016/S0002-9149(01)01448-5 contributor: fullname: Assmann – volume: 136 start-page: 41 year: 2006 ident: 10.1016/j.atherosclerosis.2008.03.008_bib16 article-title: The role of statins in clinical medicine—LDL-cholesterol lowering and beyond publication-title: Swiss Med Wkly contributor: fullname: Rutishauser – volume: 70 start-page: 826 year: 1999 ident: 10.1016/j.atherosclerosis.2008.03.008_bib25 article-title: Sitostanol administered in lecithin micelles potently reduces cholesterol absorption in humans publication-title: Am J Clin Nutr doi: 10.1093/ajcn/70.5.826 contributor: fullname: Ostlund – volume: 25 start-page: 2170 year: 2005 ident: 10.1016/j.atherosclerosis.2008.03.008_bib27 article-title: Extracellular signal-regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.0000181761.16341.2b contributor: fullname: Abidi – volume: 143 start-page: 275 year: 1999 ident: 10.1016/j.atherosclerosis.2008.03.008_bib8 article-title: Triglyceride as a risk factor for ischaemic heart disease in British men: effect of adjusting for measurement error publication-title: Atherosclerosis doi: 10.1016/S0021-9150(98)00300-1 contributor: fullname: Egger – volume: 39 start-page: 291 year: 1995 ident: 10.1016/j.atherosclerosis.2008.03.008_bib36 article-title: A diet moderately enriched in phytosterols lowers plasma cholesterol concentrations in normocholesterolemic humans publication-title: Ann Nutr Metab doi: 10.1159/000177875 contributor: fullname: Pelletier – volume: 16 start-page: 305 year: 2005 ident: 10.1016/j.atherosclerosis.2008.03.008_bib50 article-title: Free phytosterols facilitate excretion of endogenous cholesterol in gerbils publication-title: J Nutr Biochem doi: 10.1016/j.jnutbio.2004.12.013 contributor: fullname: Hayes – volume: 10 start-page: 1344 year: 2004 ident: 10.1016/j.atherosclerosis.2008.03.008_bib13 article-title: Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins publication-title: Nat Med doi: 10.1038/nm1135 contributor: fullname: Kong – volume: 11 start-page: 690 year: 1990 ident: 10.1016/j.atherosclerosis.2008.03.008_bib58 article-title: Plasma membrane bleb formation and rupture: a common feature of hepatocellular injury publication-title: Hepatology doi: 10.1002/hep.1840110425 contributor: fullname: Gores – volume: 17 start-page: 28 year: 2006 ident: 10.1016/j.atherosclerosis.2008.03.008_bib3 article-title: Recent studies of lipoprotein kinetics in the metabolic syndrome and related disorders publication-title: Curr Opin Lipidol doi: 10.1097/01.mol.0000199815.46720.ca contributor: fullname: Chan – volume: 59 start-page: 159 year: 1992 ident: 10.1016/j.atherosclerosis.2008.03.008_bib42 article-title: Studies on the antinephritic effect of plant components. (4). Reduction of protein excretion by berberine and coptisine in rats with original-type anti-GBM nephritis publication-title: Jpn J Pharmacol doi: 10.1254/jjp.59.159 contributor: fullname: Hattori – volume: 2 start-page: 171 issue: Suppl. 1 year: 2004 ident: 10.1016/j.atherosclerosis.2008.03.008_bib14 article-title: Lipid-lowering medications publication-title: Pediatr Endocrinol Rev contributor: fullname: Rodenburg – volume: 76 start-page: 1272 year: 2002 ident: 10.1016/j.atherosclerosis.2008.03.008_bib12 article-title: Unesterified plant sterols and stanols lower LDL-cholesterol concentrations equivalently in hypercholesterolemic persons publication-title: Am J Clin Nutr doi: 10.1093/ajcn/76.6.1272 contributor: fullname: Vanstone – volume: 69 start-page: 403 year: 1999 ident: 10.1016/j.atherosclerosis.2008.03.008_bib29 article-title: Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic subjects publication-title: Am J Clin Nutr doi: 10.1093/ajcn/69.3.403 contributor: fullname: Hallikainen – volume: 38 start-page: 165 year: 2003 ident: 10.1016/j.atherosclerosis.2008.03.008_bib57 article-title: Effects of policosanols and phytosterols on lipid levels and cholesterol biosynthesis in hamsters publication-title: Lipids doi: 10.1007/s11745-003-1047-3 contributor: fullname: Wang – volume: 76 start-page: 780 year: 1998 ident: 10.1016/j.atherosclerosis.2008.03.008_bib67 article-title: Gender effects of tall oil versus soybean phytosterols as cholesterol-lowering agents in hamsters publication-title: Can J Physiol Pharmacol doi: 10.1139/y98-093 contributor: fullname: Ntanios – volume: 15 start-page: 37 year: 2004 ident: 10.1016/j.atherosclerosis.2008.03.008_bib68 article-title: Phytosterols and cholesterol metabolism publication-title: Curr Opin Lipidol doi: 10.1097/00041433-200402000-00008 contributor: fullname: Ostlund – volume: 38 start-page: 599 year: 2006 ident: 10.1016/j.atherosclerosis.2008.03.008_bib53 article-title: Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte publication-title: Exp Mol Med doi: 10.1038/emm.2006.71 contributor: fullname: Choi – volume: 29 start-page: 139 year: 2007 ident: 10.1016/j.atherosclerosis.2008.03.008_bib60 article-title: Metabolic effects of two years of exenatide treatment on diabetes, obesity, and hepatic biomarkers in patients with type 2 diabetes: an interim analysis of data from the open-label, uncontrolled extension of three double-blind, placebo-controlled trials publication-title: Clin Ther doi: 10.1016/j.clinthera.2007.01.015 contributor: fullname: Buse – volume: 98 start-page: 13294 year: 2001 ident: 10.1016/j.atherosclerosis.2008.03.008_bib4 article-title: Compared with saturated fatty acids, dietary monounsaturated fatty acids and carbohydrates increase atherosclerosis and VLDL cholesterol levels in LDL receptor-deficient, but not apolipoprotein E-deficient, mice publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.231490498 contributor: fullname: Merkel – volume: 328 start-page: 313 year: 1993 ident: 10.1016/j.atherosclerosis.2008.03.008_bib6 article-title: Serum cholesterol in young men and subsequent cardiovascular disease publication-title: N Engl J Med doi: 10.1056/NEJM199302043280504 contributor: fullname: Klag – volume: 52 start-page: 334 year: 1998 ident: 10.1016/j.atherosclerosis.2008.03.008_bib34 article-title: Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects publication-title: Eur J Clin Nutr doi: 10.1038/sj.ejcn.1600559 contributor: fullname: Weststrate – volume: 109 start-page: 407 year: 2003 ident: 10.1016/j.atherosclerosis.2008.03.008_bib62 article-title: Induction of interleukin-12 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid, deviates CD4+ T cells from a Th2 to a Th1 response publication-title: Immunology doi: 10.1046/j.1365-2567.2003.01673.x contributor: fullname: Kim – volume: 80 start-page: 1159 year: 2004 ident: 10.1016/j.atherosclerosis.2008.03.008_bib20 article-title: Plant sterols and endurance training combine to favorably alter plasma lipid profiles in previously sedentary hypercholesterolemic adults after 8wk publication-title: Am J Clin Nutr doi: 10.1093/ajcn/80.5.1159 contributor: fullname: Varady – volume: 135 start-page: 2499 year: 2005 ident: 10.1016/j.atherosclerosis.2008.03.008_bib46 article-title: Comparative aspects of lipid metabolism: impact on contemporary research and use of animal models publication-title: J Nutr doi: 10.1093/jn/135.11.2499 contributor: fullname: Bergen – volume: 123 start-page: 1939 year: 1993 ident: 10.1016/j.atherosclerosis.2008.03.008_bib70 article-title: AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet publication-title: J Nutr doi: 10.1093/jn/123.11.1939 contributor: fullname: Reeves – volume: 85 start-page: 42 issue: Suppl. 5 year: 2005 ident: 10.1016/j.atherosclerosis.2008.03.008_bib18 article-title: Mechanisms of rhabdomyolysis with statins publication-title: Arq Bras Cardiol contributor: fullname: Magalhaes – volume: 105 start-page: 46 year: 2005 ident: 10.1016/j.atherosclerosis.2008.03.008_bib35 article-title: Plant sterol/stanol prescription is an effective treatment strategy for managing hypercholesterolemia in outpatient clinical practice publication-title: J Am Diet Assoc doi: 10.1016/j.jada.2004.10.024 contributor: fullname: Patch – volume: 47 start-page: 2134 year: 2006 ident: 10.1016/j.atherosclerosis.2008.03.008_bib26 article-title: The medicinal plant goldenseal is a natural LDL-lowering agent with multiple bioactive components and new action mechanisms publication-title: J Lipid Res doi: 10.1194/jlr.M600195-JLR200 contributor: fullname: Abidi – volume: 69 start-page: 1144 year: 1999 ident: 10.1016/j.atherosclerosis.2008.03.008_bib30 article-title: Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men publication-title: Am J Clin Nutr doi: 10.1093/ajcn/69.6.1144 contributor: fullname: Jones – volume: 173 start-page: 269 year: 2004 ident: 10.1016/j.atherosclerosis.2008.03.008_bib40 article-title: Soy protein reduces triglyceride levels and triglyceride fatty acid fractional synthesis rate in hypercholesterolemic subjects publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2003.12.015 contributor: fullname: Wang – volume: 60 start-page: 633 year: 2006 ident: 10.1016/j.atherosclerosis.2008.03.008_bib21 article-title: Safety aspects and cholesterol-lowering efficacy of low fat dairy products containing plant sterols publication-title: Eur J Clin Nutr doi: 10.1038/sj.ejcn.1602362 contributor: fullname: Korpela |
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Snippet | Abstract The objective of the present study was to determine the beneficial effects and the safety of oral administration of the combination of berberine (BBR)... The objective of the present study was to determine the beneficial effects and the safety of oral administration of the combination of berberine (BBR) and... |
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SubjectTerms | Administration, Oral Animals Anticholesteremic Agents - administration & dosage Atherosclerosis (general aspects, experimental research) Berberine Berberine - administration & dosage Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Cholesterol - blood Coronary heart disease Diet, Atherogenic Drug Therapy, Combination Heart Lipoproteins - blood Liver cholesterol Male Medical sciences Phytosterols - administration & dosage Plant stanols Plasma cholesterol Plasma triacylglyceride Rats Rats, Sprague-Dawley Sitosterols - administration & dosage Toxicity Triglycerides - blood |
Title | Co-administration of berberine and plant stanols synergistically reduces plasma cholesterol in rats |
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