NoncoRNA: a database of experimentally supported non-coding RNAs and drug targets in cancer

• Published in: Journal of hematology and oncology Vol. 13; no. 1; p. 15
• Main Authors: Li, Lulu, Wu, Pengfei, Wang, Zhenyu, Meng, Xiangqi, Zha, Caijun, Li, Ziwei, Qi, Tengfei, Zhang, Yangong, Han, Bo, Li, Shupeng, Jiang, Chuanlu, Zhao, Zheng, Cai, Jinquan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.02.2020; BioMed Central; BMC
• Subjects: Anopheles; Antineoplastic agents; Antineoplastic Agents - pharmacology; Cancer; Cancer therapies; Databases, Nucleic Acid; Diseases; Drug Discovery; Drug resistance; Drug Resistance, Neoplasm; Drug therapy; Drugs; Gene regulation; Genes; Genetic regulation; Human cancer; Humans; Laboratories; Letter to the Editor; MicroRNAs; Molecular Targeted Therapy; Mortality; Neoplasms - drug therapy; Neoplasms - genetics; Nervous system diseases; Neurodegenerative diseases; Non-coding RNA; Ribonucleic acid; RNA; RNA, Untranslated - genetics; Therapeutic targets; Database; Human cancer; Drug resistance; Non-coding RNA
• ISSN: 1756-8722; 1756-8722
• DOI: 10.1186/s13045-020-00849-7

NoncoRNA (http://www.ncdtcdb.cn:8080/NoncoRNA/) is a manually curated database of experimentally supported non-coding RNAs (ncRNAs) and drug target associations that aim to potentially provide a high-quality data resource for exploring drug sensitivity/resistance-related ncRNAs in various human cancers. ncRNA are RNA molecular that do not encode proteins, but are involved in gene regulation and cellular functions in variety of human diseases, including neurodegenerative diseases and cancers. Here, we developed NoncoRNA which contained 8233 entries between 5568 ncRNAs and 154 drugs in 134 cancers. Each entry in the NoncoRNA contains detailed information on the ncRNAs, drugs, and cancers, the ncRNA expression pattern and experimental detection techniques, drug response and other targets, literature references, and other information. NoncoRNA offers a user-friendly, open access web interface to easily browse, search, and download data. NoncoRNA also provides a submission page for researchers to submit newly validated ncRNA-drug-cancer associations. NoncoRNA might serve as an immeasurable resource for understanding the roles of ncRNAs in cancer therapy.