Facilitating drug delivery in the central nervous system by opening the blood-cerebrospinal fluid barrier with a single low energy shockwave pulse

• Published in: Fluids and barriers of the CNS Vol. 19; no. 1; pp. 3 - 13
• Main Authors: Kung, Yi, Chen, Kuan-Yu, Liao, Wei-Hao, Hsu, Yi-Hua, Wu, Chueh-Hung, Hsiao, Ming-Yen, Huang, Abel P.-H., Chen, Wen-Shiang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.01.2022; BioMed Central; BMC
• Subjects: Analysis; Animals; Anti-Bacterial Agents - pharmacokinetics; Antineoplastic Agents - pharmacokinetics; Bevacizumab; Blood; Blood-Brain Barrier; Blood-cerebrospinal fluid barrier; Brain cancer; Brain research; Brain tumors; Central nervous system; Cerebrospinal Fluid; Choroid Plexus; Dextran; Doxorubicin; Drug delivery; Drug delivery systems; Drug Delivery Systems - instrumentation; Drug Delivery Systems - methods; Drugs; Energy; Glioblastoma; Glioblastoma multiforme; Laboratory animals; Leptomeningeal carcinomatosis; Low-energy extracorporeal focused shockwave pulse; Meninges; Monoclonal antibodies; Nervous system; Neurodegenerative diseases; Penicillin; Penicillin G; Rats; Rats, Sprague-Dawley; Sound; Spinal cord; Ultrasonic imaging; Vehicles; United States > US; Low-energy extracorporeal focused shockwave pulse; Blood-cerebrospinal fluid barrier; Glioblastoma multiforme; Central nervous system; Blood–brain barrier; Leptomeningeal carcinomatosis

The blood-cerebrospinal fluid (CSF) barrier (BCSFB) is critically important to the pathophysiology of the central nervous system (CNS). However, this barrier prevents the safe transmission of beneficial drugs from the blood to the CSF and thus the spinal cord and brain, limiting their effectiveness...