Biomarkers of lipid metabolism in patients with juvenile idiopathic arthritis: relationship with disease subtype and inflammatory activity

• Published in: Pediatric Rheumatology Vol. 19; no. 1; p. 66
• Main Authors: Rodrigues, Wellington Douglas Rocha, Sarni, Roseli Oselka Saccardo, Fonseca, Fernando Luiz Affonso, Araújo, Annelyse, Len, Claudio Arnaldo, Terreri, Maria Teresa
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.05.2021; BioMed Central; BMC
• Subjects: Acute-phase proteins; Acute-Phase Proteins - analysis; Adolescent; Apolipoprotein A-I - blood; Apolipoproteins; Arthritis; Arthritis, Juvenile - blood; Arthritis, Juvenile - diagnosis; Arthritis, Juvenile - epidemiology; Arthritis, Juvenile - physiopathology; Biological markers; Biomarkers; Biomarkers - analysis; Blood; Blood Sedimentation; Body Mass Index; Brazil - epidemiology; C-reactive protein; Care and treatment; Caregivers; Child; Cholesterol; Cholesterol, HDL - blood; Chronic illnesses; Cross-Sectional Studies; Disease; Dyslipidemias - diagnosis; Dyslipidemias - etiology; Female; Food; Humans; Immunologic Tests - methods; Insulin; Juvenile idiopathic arthritis; Laboratories; Lipid Metabolism; Lipids; Lipoproteins; Low density lipoproteins; Male; Medical examination; Medical research; Medicine, Experimental; Metabolism; Nutritional Status; Patient Acuity; Pediatrics; Physiological aspects; Rheumatoid arthritis; Rheumatology; Teenagers; Triglycerides; Variables; Brazil; Acute-phase proteins; Apolipoproteins; Cholesterol; Juvenile idiopathic arthritis
• ISSN: 1546-0096; 1546-0096
• DOI: 10.1186/s12969-021-00538-w

To describe the biomarkers of lipid metabolism in children and adolescents with polyarticular and systemic JIA and to relate them to diseases subtypes, diseases activity markers, and nutritional status. A cross-sectional study including 62 JIA patients was performed. The following variables were evaluated: disease activity and medications used, body mass index, height for age (z-score), skin folds (bicipital, tricipital, subscapular and suprailiac), food intake based on three 24-h food recalls, lipid profile (total cholesterol (CT), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG) and non-HDL (N-HDLc), glycemia and insulin, erythrocyte sedimentation rate (ESR), ultrasensitive C-reactive protein (us-CRP) and apolipoproteins A-I and B (Apo A-I and Apo B). Dyslipidemia was observed in 83.3% of the patients. Based on classical lipid profile, low HDL-c levels was the most frequently alteration observed. Inadequate levels of LDL-c, Apo B and NHDL-c were significantly more frequent in the systemic JIA subtype when compared to the polyarticular subtype (p = 0.017, 0.001 and 0.042 respectively). Patients on biological therapy had a better adequacy of Apo A-I concentrations. The ESR showed a negative correlation with Apo A-I level (r = - 0.25, p = 0.047). We concluded that dyslipidemia is common in patients with JIA, especially in systemic subtype. The systemic subtype and an elevated ESR were associated with lower concentrations of Apo A-I, suggesting the participation of the inflammatory process.