Portal Vein Pulsatility Index as a Potential Risk of Venous Congestion Assessed by Magnetic Resonance Imaging: A Prospective Study on Healthy Volunteers

• Published in: Frontiers in Physiology Vol. 13; p. 811286
• Main Authors: Abou-Arab, Osama, Beyls, Christophe, Moussa, Mouhamed Djahoum, Huette, Pierre, Beaudelot, Elodie, Guilbart, Mathieu, de Broca, Bruno, Yzet, Thierry, Dupont, Herve, Bouzerar, Roger, Mahjoub, Yazine
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media SA 29.04.2022; Frontiers; Frontiers Media S.A
• Subjects: [SDV]Life Sciences [q-bio]; fluid challenge; fluid responsiveness; Life Sciences; magnetic resonance imaging; Physiology; portal vein pulsatility; QP1-981; venous congestion; fluid responsiveness; magnetic resonance imaging; venous congestion; fluid challenge; portal vein pulsatility
• ISSN: 1664-042X; 1664-042X
• DOI: 10.3389/fphys.2022.811286

High values of the portal vein pulsatility index (PI) have been associated with adverse outcomes in perioperative or critically ill patients. However, data on dynamic changes of PI related to fluid infusion are scarce. We aimed to determine if dynamic changes in PI are associated with the fluid challenge (FC). To address this challenge, we conducted a prospective single-center study. The population study included healthy subjects. FC consisted in the administration of 500 ml of Ringer lactate infusion over 5 min. The portal blood flow and PI were assessed by magnetic resonance imaging. The responsiveness to FC was defined as an increase in the cardiac stroke volume of at least 10% as assessed by echocardiography. We included 24 healthy volunteers. A total of fourteen (58%) subjects were responders, and 10 (42%) were non-responders. In the responder group, FC induced a significant increase in portal blood flow from 881 (762–1,001) at the baseline to 1,010 (778–1,106) ml min −1 ( p = 0.005), whilst PI remained stable (from 31 [25–41] to 35 (25–42) %; p = 0.12). In the non-responder group, portal blood flow remained stable after FC (from 1,042 to 1,034 ml min −1 ; p = 0.084), whereas PI significantly increased from 32 (22–40) to 48% *(25–85) after FC ( p = 0.027). PI was negatively correlated to portal blood flow (Rho coefficient = −0.611; p = 0.002). To conclude, PI might be a sensitive marker of early congestion in healthy subjects that did not respond to FC. This finding requires further validation in clinical settings with a larger sample size.