Effects of factor v Leiden polymorphism on the pathogenesis and outcomes of preeclampsia

• Published in: BMC medical genetics Vol. 20; no. 1; pp. 189 - 6
• Main Authors: Ababio, G. K., Adu-Bonsaffoh, K., Abindau, E., Narh, G., Tetteh, D., Botchway, F., Morvey, D., Neequaye, J., Quaye, I. K.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 27.11.2019; BioMed Central; BMC
• Subjects: Adult; Alleles; Automation; Births; Blood pressure; Blood tests; Coagulation factors; Data security; Dehydrogenases; Development and progression; Disease; Enzymes; Ethical aspects; Etiology; Etiology (Medicine); Exons; Factor V; Factor V - genetics; Female; Gene Frequency; Gene polymorphism; Genetic aspects; Genetic polymorphisms; Glycosylated hemoglobin; Health; Hemoglobin; Hemoglobins; Hepatocytes; Humans; Hypertension; Leiden; Leukocytes; Liver; Maternal mortality; Medical records; Mutation; Pathogenesis; Polymerase chain reaction; Polymorphism; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Pre-eclampsia; Pre-Eclampsia - genetics; Pre-Eclampsia - pathology; Preeclampsia; Pregnancy; Pregnancy Outcome; Proteins; Proteinuria; Purines; Restriction; Restriction fragment length polymorphism; Teaching hospitals; Uric acid; Urine; Variables; Womens health; Canada; Ghana; Factor V; Polymerase chain reaction; Restriction; Leiden; Preeclampsia

Factor V Leiden polymorphism is a well-recognized genetic factor in the etiology of preeclampsia. Considering that Ghana is recording high incidence of preeclampsia, we examined if factor V Leiden is a contributory factor to its development and pregnancy outcomes. STROBE consensus checklist was adop...