Loudness dependence of auditory evoked potentials (LDAEP) correlates with the availability of dopamine transporters and serotonin transporters in healthy volunteers—a two isotopes SPECT study

• Published in: Psychopharmacologia Vol. 214; no. 3; pp. 617 - 624
• Main Authors: Lee, I Hui, Yang, Yen Kuang, Chen, Po See, Huang, Hui Chun, Yeh, Tzung Lieh, Lu, Ru-Band, Chiu, Nan-Tsing, Yao, Wei Jen, Lin, Shih-Hsien
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2011; Springer; Springer Nature B.V
• Subjects: Acoustic Stimulation - methods; Adult; Auditory evoked potentials; Auditory evoked response; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Brain - diagnostic imaging; Brain - physiology; Brain Mapping; Cinanserin - analogs & derivatives; Computed tomography; Dopamine; Dopamine Plasma Membrane Transport Proteins - metabolism; Dopamine transporter; Evoked Potentials, Auditory - physiology; Female; Humans; Isotopes; Loudness (Acoustics); Loudness Perception - physiology; Male; Medical sciences; Middle Aged; Monoamine transporter; Neurological research; Neuropsychology; Neurosciences; Organotechnetium Compounds; Original Investigation; Pharmacology/Toxicology; Phenols; Physiological aspects; Psychiatry; Psychopharmacology; Radiopharmaceuticals; Regression Analysis; Serotonin; Serotonin Plasma Membrane Transport Proteins - metabolism; Serotonin transporter; Single photon emission computed tomography; SPECT imaging; Tomography, Emission-Computed, Single-Photon - methods; Tropanes; Young Adult; Taiwan; Dopamine transporter; Loudness dependence auditory evoked potentials (LDAEPs); Serotonin transporter; Event-related evoked potential (ERP); SPECT; Availability; Human; Loudness; Healthy subject; Electrophysiology; Sound intensity; Photon; Evoked potential; Auditory evoked potential; Dependence; Event evoked potential; Emission tomography
• ISSN: 0033-3158; 1432-2072; 1432-2072
• DOI: 10.1007/s00213-010-2064-8

Rationale and objective Although loudness dependence of auditory evoked potentials (LDAEPs) had been suggested as a noninvasive measure of central serotonin functions, recent studies suggest that LDAEP may be modulated by multiple neuromodulatory systems, such as dopamine. Here, we explore the relationship between LDAEP and dopamine and serotonin in the level of monoamine transporter availability. Methods Forty-nine healthy volunteers received LDAEP and single-photon emission computed tomography (SPECT) using [ 99m Tc] TRODAT and [ 123 I] ADAM to approximate the availability of dopamine transporters (DATs) and serotonin transporters (SERTs). Results LDAEP was found to be positively associated with DAT, after adjusting for age and gender, and the log-transformed slope of loudness dependence at Cz was negatively associated with SERT. Conclusion Our findings provide further evidence for the possible involvement of dopamine and serotonins in the genesis of LDAEP.