Parasitic Helminths : New Weapons against Immunological Disorders

The prevalence of allergic and autoimmune diseases is increasing in developed countries, possibly due to reduced exposure to microorganisms in childhood (hygiene hypothesis). Epidemiological and experimental evidence in support of this hypothesis is accumulating. In this context, parasitic helminths...

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Bibliographic Details
Published inBioMed research international Vol. 2010; no. 2010; pp. 1 - 9
Main Authors Osada, Yoshio, Kanazawa, Tamotsu
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Puplishing Corporation 01.01.2010
Hindawi Publishing Corporation
Hindawi Limited
Subjects
Animals
Arthritis
Arthritis, Experimental - immunology
Arthritis, Experimental - prevention & control
Asthma
Autoimmune diseases
Autoimmune Diseases - immunology
Autoimmune Diseases - prevention & control
Diabetes
Gene expression
Hay fever
Helminths - immunology
Humans
Immune System Diseases - immunology
Immune System Diseases - prevention & control
Inflammatory bowel disease
Parasites - immunology
Pathogenesis
Regulation
Review
Schistosoma mansoni
Studies
T-Lymphocytes, Helper-Inducer - immunology
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Summary:The prevalence of allergic and autoimmune diseases is increasing in developed countries, possibly due to reduced exposure to microorganisms in childhood (hygiene hypothesis). Epidemiological and experimental evidence in support of this hypothesis is accumulating. In this context, parasitic helminths are now important candidates for antiallergic/anti-inflammatory agents. Here we summarize antiallergic/anti-inflammatory effects of helminths together along with our own study of the effects of Schistosoma mansoni on Th17-dependent experimental arthritis. We also discuss possible mechanisms of helminth-induced suppression according to the recent advances of immunology.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Academic Editor: Luis I. Terrazas
ISSN:1110-7243
2314-6133
1110-7251
2314-6141
DOI:10.1155/2010/743758