Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research: Novel Atherosclerosis Model Induced by High Fat and Cholesterol Diet

Atherosclerotic lesions were observed in male and ovariectomized female Microminipig (MMP) fed a high fat and cholesterol diet with sodium cholate (HFCD/SC) for 3 months. HFCD/SC induced hypercholesterolemia accompanied by an increase in serum total cholesterol (T-Cho), low-density lipoprotein chole...

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Published inJournal of Pharmacological Sciences Vol. 115; no. 2; pp. 115 - 121
Main Authors Kawaguchi, Hiroaki, Miyoshi, Noriaki, Miura, Naoki, Fujiki, Makoto, Horiuchi, Masahisa, Izumi, Yasukatsu, Miyajima, Hiroaki, Nagata, Ryoichi, Misumi, Kazuhiro, Takeuchi, Toru, Tanimoto, Akihide, Yoshida, Hiroki
Format Journal Article
LanguageEnglish
Japanese
Published Japan Elsevier B.V 2011
The Japanese Pharmacological Society
Elsevier
Subjects
Animals
atherosclerosis
Atherosclerosis - blood
Atherosclerosis - pathology
Breeding
cholesterol
Cholesterol - blood
Cholesterol, Dietary - administration & dosage
diet
Diet, Atherogenic
Dietary Fats - administration & dosage
Disease Models, Animal
Female
Humans
life-style
Lipids - blood
Male
Microminipig
Swine
Swine, Miniature
atherosclerosis
Microminipig
cholesterol
diet
life-style
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Summary:Atherosclerotic lesions were observed in male and ovariectomized female Microminipig (MMP) fed a high fat and cholesterol diet with sodium cholate (HFCD/SC) for 3 months. HFCD/SC induced hypercholesterolemia accompanied by an increase in serum total cholesterol (T-Cho), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and cholesterol ester (CE). Unlike the mouse or rabbit, a dominant LDL-C fraction in the intact MMP, similar to that in humans, was observed by serum lipoprotein analysis. HFCD/SC increased body weight gain. At the end of the experiment, computed tomography scans of conscious animals showed that HFCD/SC had decreased liver attenuation values (Hounsfield unit) and increased subcutaneous and abdominal fat, suggesting the induction of fatty liver and obesity. HFCD/SC induced atherosclerotic lesions in systemic arteries, including the external and internal iliac arteries, abdominal aorta, coronary artery, and cerebral arterial circle. Atherosclerosis and pathological findings induced by HFCD/SC in MMP were similar to those in humans. The MMP is a potentially suitable tool for investigating human atherosclerosis.
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ISSN:1347-8613
1347-8648
DOI:10.1254/jphs.10R17FM