“Switched” metabolic acidosis in mitochondrial diabetes mellitus

A patient with mitochondrial diabetes mellitus developed diabetic ketoacidosis. During insulin treatment, although diabetic ketoacidosis improved, lactic acidosis unexpectedly worsened. This clinical course, named “switched metabolic acidosis,” could reflect the unique pathophysiology of the mitocho...

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Bibliographic Details
Published inJournal of diabetes investigation Vol. 10; no. 4; pp. 1116 - 1117
Main Authors Keidai, Yamato, Iwasaki, Yorihiro, Honjo, Sachiko, Aizawa‐Abe, Megumi, Iwasaki, Kanako, Hamasaki, Akihiro
Format Journal Article
LanguageEnglish
Published Japan John Wiley & Sons, Inc 01.07.2019
John Wiley and Sons Inc
Wiley
Subjects
Acidosis
Acidosis - drug therapy
Acidosis - etiology
Adenine
Adenosine kinase
Aged
AMP
Deoxyribonucleic acid
Diabetes
Diabetes Complications - drug therapy
Diabetes Complications - etiology
Diabetes mellitus
Diabetes Mellitus - physiopathology
DNA
Female
Glucose
Hepatocytes
Humans
Insulin
Ketoacidosis
Kinases
Lactic acid
Letter to the Editor
Metabolic acidosis
Metabolism
Mitochondria
Mitochondrial Diseases - complications
NAD
Nicotinamide
Oxidative metabolism
Patients
Prognosis
Protein kinase
Pyruvic acid
Vitamin B
Vitamin deficiency
Japan
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Summary:A patient with mitochondrial diabetes mellitus developed diabetic ketoacidosis. During insulin treatment, although diabetic ketoacidosis improved, lactic acidosis unexpectedly worsened. This clinical course, named “switched metabolic acidosis,” could reflect the unique pathophysiology of the mitochondrial disorder.
ISSN:2040-1116
2040-1124
DOI:10.1111/jdi.12992