尿酸与颈动脉粥样硬化斑块的关系研究进展

目前尚不清楚尿酸和颈动脉粥样硬化斑块之间是否有直接或间接的因果关系。一些研究发现,尿酸可能在颈动脉粥样硬化斑块的发病机制中起作用;而另外一些研究显示尚不能确定尿酸是独立危险因素。此外,尿酸作为一种内源性抗氧化剂,可能有神经保护作用。为找到明确的答案,仍然需要进行更多基础和临床试验研究。...

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Bibliographic Details
Published in中国卒中杂志 Vol. 9; no. 11; pp. 975 - 979
Main Author 李勍 赵锡海 赵性泉
Format Journal Article
LanguageChinese
Published 100050北京首都医科大学附属北京天坛医院神经内科 2014
新疆自治区人民医院神经内科%清华大学医学院生物医学影像研究中心%100050北京首都医科大学附属北京天坛医院神经内科
Subjects
尿酸
斑块
颈动脉,动脉粥样硬化
高尿酸血症
高尿酸血症
尿酸
Hyperuricemia
Carotid artery,Atherosclerosis
颈动脉,动脉粥样硬化
斑块
Uric acid
Plaque
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Summary:目前尚不清楚尿酸和颈动脉粥样硬化斑块之间是否有直接或间接的因果关系。一些研究发现,尿酸可能在颈动脉粥样硬化斑块的发病机制中起作用;而另外一些研究显示尚不能确定尿酸是独立危险因素。此外,尿酸作为一种内源性抗氧化剂,可能有神经保护作用。为找到明确的答案,仍然需要进行更多基础和临床试验研究。
Bibliography:11-5434/R
Uric acid;Hyperuricemia;Carotid artery,Atherosclerosis;Plaque
Although in the past decade a large number of studies have been performed to identify the relationship between uric acid and carotid atherosclerotic plaques, the issue remains unresolved and it is not clear whether the correlation between uric acid and carotid plaques is circumstantial or causal. This review will evaluate the association between uric acid and carotid atherosclerotic plaques. Some studies have found uric acid may have a role in the pathogenesis of carotid plaques, whereas others have failed to identify uric acid as a signiifcant and independent risk factor after controlling for other atherosclerotic risk factors. Furthermore, uric acid, an endogenous antioxidant, may have a neuroprotective role. More trials are required to provide deifnite answers in clinical practice in the future.
LI Qing, ZHAO Xi-Hai, ZHAO Xing-Quan （Department of Neurology, Beijing Tiantan Hospital Capital Medical University, Beijing 100050, China）
ISSN:1673-5765
DOI:10.3969/j.issn.1673-5765.2014.11.014