免疫杀伤细胞治疗对恶性肿瘤患者调节性T细胞的影响

目的探讨免疫杀伤细胞治疗对恶性肿瘤患者CD4＋CD25＋CD127LOW、CD8＋CD28-调节性T细胞的影响。方法选择2011年5月至2014年4月该院肿瘤内科收治的接受免疫杀伤细胞治疗的恶性肿瘤患者50例作为研究对象（肿瘤组）,同时选择该院健康体检者30例为对照组。采用流式细胞术检测所有受检对象治疗前后外周血CD4＋CD25＋CD127LOW和CD8＋CD28-调节性T细胞的含量。结果肿瘤组治疗前外周血CD4＋CD25＋CD127LOW/CD4＋、CD8＋CD28-/CD8＋（11.48%±1.44%、19.69%±5.01%）明显高于对照组（4.65%±0.75%、15.35%±4.71...

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Published in现代医药卫生 Vol. 32; no. 7; pp. 972 - 974
Main Author 韩兆东 阮月芹 韩晓通 梁葵香 孙其静 李卫
Format Journal Article
LanguageChinese
Published 滨州医学院附属医院中心实验室,山东滨州,256603%滨州医学院附属医院检验科,山东滨州,256603%滨州医学院附属医院疼痛科,山东滨州,256603%滨州医学院附属医院产科,山东滨州,256603 2016
Subjects
T淋巴细胞,调节性
抗原,CD28
抗原,CD4
抗原,CD8
杀伤细胞
流式细胞术
肿瘤
Antigens,CD28
Flow cytometry
抗原,CD4
Antigens,CD4
T淋巴细胞,调节性
Neoplasms
T-lymphocytes,regulatory
Killer cells
杀伤细胞
肿瘤
Antigens,CD8
抗原,CD8
抗原,CD28
流式细胞术
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Summary:目的探讨免疫杀伤细胞治疗对恶性肿瘤患者CD4＋CD25＋CD127LOW、CD8＋CD28-调节性T细胞的影响。方法选择2011年5月至2014年4月该院肿瘤内科收治的接受免疫杀伤细胞治疗的恶性肿瘤患者50例作为研究对象（肿瘤组）,同时选择该院健康体检者30例为对照组。采用流式细胞术检测所有受检对象治疗前后外周血CD4＋CD25＋CD127LOW和CD8＋CD28-调节性T细胞的含量。结果肿瘤组治疗前外周血CD4＋CD25＋CD127LOW/CD4＋、CD8＋CD28-/CD8＋（11.48%±1.44%、19.69%±5.01%）明显高于对照组（4.65%±0.75%、15.35%±4.71%）,差异有统计学意义（P〈0.05）。肿瘤组治疗后外周血CD4＋CD25＋CD127LOW/CD4＋、CD8＋CD28-/CD8＋（5.55%±0.81%、16.15%±4.61%）明显低于治疗前,差异均有统计学意义（P〈0.05﹚;略高于对照组,但差异无统计学意义（P〉0.05）。结论免疫杀伤细胞治疗恶性肿瘤,能够降低肿瘤患者外周血CD4＋CD25＋CD127LOW、CD8＋CD28-调节性T细胞水平,纠正机体免疫失衡状态,提高免疫功能。
Bibliography:Han Zhaodong,Ruan Yueqin,Han Xiaotong,Liang Kuixiang,Sun Qijing,Li Wei （1. Central Laboratory;2. Department of Clinical laboratory;3. Department of Pain;4. Department of Obstetrics ,Affiliated Hospital of Binzhou Medical College ,Binzhou ,Shandong 256603 , China）
Killer cells; T-lymphocytes; regulatory; Neoplasms; Antigens; CD4; Antigens; CD8; Antigens; CD28; Flow cytometry
Objective To investigate the effect of immune killer cells therapy on CD4＋CD25＋CD127LOWand CD8＋CD28-regulatory T cells in the patients with malignant tumor. Methods Fifty patients with malignant tumor treated by the immune killer cells therapy in the oncology department of our hospital from May 2011 to April 2014 were taken as the research subjects（tumor group） and 30 individuals undergoing the healthy physical examination were selected as the control group. Flow cytometry was used to detect the peripheral blood CD4＋CD25＋CD127LOWand T regulatory CD4＋cells with CD8＋CD28-and CD8＋. Results The peripheral blood CD4＋CD25＋CD127LOW/CD4＋and CD8＋CD28
ISSN:1009-5519
DOI:10.3969/j.issn.1009-5519.2016.07.004