Altered superoxide dismutase-1 activity and intercellular adhesion molecule 1 (ICAM-1) levels in patients with type 2 diabetes mellitus

• Published in: PloS one Vol. 14; no. 5; p. e0216256
• Main Authors: Tavares, Anderson Martins, Silva, Jaslana Hainfellner, Bensusan, Christiane de Oliveira, Ferreira, Andrea Claudia Freitas, Matos, Livia Pinto de Lima, e Souza, Kleber Luiz de Araujo, Cardoso-Weide, Luciene de Carvalho, Taboada, Giselle Fernandes
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.05.2019; Public Library of Science (PLoS)
• Subjects: Adhesion; Adhesion tests; Aged; Analysis; Anticoagulants; Antioxidants; Antioxidants (Nutrients); Biological markers; Biological research; Biology and life sciences; Biomarkers - blood; Case-Control Studies; Cell adhesion; Cell adhesion molecules; Complications; Correlation; Cytokines; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; Diabetes therapy; Diabetic retinopathy; Enzymes; Female; Glucose; Glutathione; Glutathione peroxidase; Glycated Hemoglobin - analysis; Glycosylated hemoglobin; Hemoglobin; Hemoglobins; Humans; Hyperglycemia; Inflammation; Insulin; Intercellular adhesion molecule 1; Intercellular Adhesion Molecule-1 - blood; Male; Medicine and health sciences; Metabolism; Middle Aged; Necrosis; Nitric oxide; Nitrogen oxides; Oxidative Stress; Patients; Peroxidase; Physical Sciences; Prediabetic state; Prediabetic State - blood; Sulfur compounds; Superoxide dismutase; Superoxide Dismutase - blood; Superoxide Dismutase - metabolism; Superoxides; Thiols; Tumor necrosis factor; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Tumors; Type 2 diabetes; Work capacity; Brazil; Rio de Janeiro Brazil; United States > US; Michigan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0216256

Inflammation and oxidative stress are linked to type 2 diabetes mellitus (T2DM). In this work, we analyzed patients' blood markers of antioxidant capacity, oxidative stress and inflammation in individuals with T2DM, in pre-diabetes state (pre-DM) and controls without diabetes. Patients were divided into three groups, according to glycated hemoglobin A1c (HbA1c): <7%, 7-9%, and >9%. Superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities, total thiols, nitric oxide (•NO), tumor necrosis factor alpha (TNF-α) and intercellular adhesion molecule 1 (ICAM-1) levels of the individuals were measured. Plasma SOD activity was higher in T2DM subjects compared to the controls. While total thiols levels were lower in T2DM groups when compared to pre-DM, the values remained unchanged when compared to controls. ICAM-1 levels of T2DM groups were lower than in controls, while GPx activity, •NO, and TNF-α levels were similar among all groups. A positive correlation was found between SOD and HbA1c levels. Concluding, individuals with T2DM present altered SOD activity, total thiols, and ICAM-1 levels, which might contribute to further complications. There is a positive correlation between SOD activity and HbA1c levels. No apparent correlation exists between total thiols and ICAM-1 levels and with any other of the parameters evaluated in this study.