Borrelidin is an Angiogenesis Inhibitor; Disruption of Angiogenic Capillary Vessels in a Rat Aorta Matrix Culture Model
Borrelidin, an antibiotic from Streptomyces rochei, was found to be an angiogenesis inhibitor in a rat aorta matrix culture model which forms capillary vessels in vitro. Borrelidin strongly inhibited capillary tube formation with a 50%-inhibitory concentration value of O.SnM, and decreased the numbe...
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Published in | Journal of antibiotics Vol. 50; no. 8; pp. 671 - 676 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Tokyo
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
01.08.1997
Japan Antibiotics Research Association |
Subjects | |
Online Access | Get full text |
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Summary: | Borrelidin, an antibiotic from Streptomyces rochei, was found to be an angiogenesis inhibitor in a rat aorta matrix culture model which forms capillary vessels in vitro. Borrelidin strongly inhibited capillary tube formation with a 50%-inhibitory concentration value of O.SnM, and decreased the number of capillary tubes within 24 hours when added after maturation of tube formation. Borrelidin remarkably disrupted capillary tubes in a dose-dependent manner, by inducing apoptosis of the tube-forming cells. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0021-8820 1881-1469 |
DOI: | 10.7164/antibiotics.50.671 |