Borrelidin is an Angiogenesis Inhibitor; Disruption of Angiogenic Capillary Vessels in a Rat Aorta Matrix Culture Model

Borrelidin, an antibiotic from Streptomyces rochei, was found to be an angiogenesis inhibitor in a rat aorta matrix culture model which forms capillary vessels in vitro. Borrelidin strongly inhibited capillary tube formation with a 50%-inhibitory concentration value of O.SnM, and decreased the numbe...

Full description

Saved in:
Bibliographic Details
Published inJournal of antibiotics Vol. 50; no. 8; pp. 671 - 676
Main Authors WAKABAYASHI, TOSHIAKI, KAGEYAMA, RENA, NARUSE, NOBUAKI, TSUKAHARA, NAOKO, FUNAHASHI, YASUHIRO, KITOH, KYOSUKE, WATANABET, YOSHIO
Format Journal Article
LanguageEnglish
Published Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 01.08.1997
Japan Antibiotics Research Association
Subjects
Animals
Anti-Bacterial Agents - pharmacology
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antineoplastic agents
Aorta - drug effects
Aorta - ultrastructure
Apoptosis - drug effects
Applied microbiology
Biological and medical sciences
Capillaries - drug effects
Capillaries - growth & development
Cell Division - drug effects
Cells, Cultured
Chemotherapic agents
Chemotherapy
Fatty Alcohols - pharmacology
Fundamental and applied biological sciences. Psychology
Humans
Male
Medical sciences
Mice
Microbiology
Muscle, Smooth, Vascular - drug effects
Neovascularization, Pathologic - prevention & control
Pharmacology. Drug treatments
Rats
Rats, Sprague-Dawley
Antineoplastic agent
Streptomycetaceae
Rat
Rodentia
Streptomyces
In vitro
Biological activity
Capillary tube
Actinomycetales
Angiogenesis
Microcirculation
Vertebrata
Antibiotic
Mammalia
Microbial origin
Animal
Blood vessel
Bacteria
Aorta
Actinomycetes
Inhibitor
Circulatory system
Mechanism of action
Apoptosis
Online AccessGet full text

Cover

More Information
Summary:Borrelidin, an antibiotic from Streptomyces rochei, was found to be an angiogenesis inhibitor in a rat aorta matrix culture model which forms capillary vessels in vitro. Borrelidin strongly inhibited capillary tube formation with a 50%-inhibitory concentration value of O.SnM, and decreased the number of capillary tubes within 24 hours when added after maturation of tube formation. Borrelidin remarkably disrupted capillary tubes in a dose-dependent manner, by inducing apoptosis of the tube-forming cells.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.50.671