Mortality and years of life lost by colorectal cancer attributable to physical inactivity in Brazil (1990-2015): Findings from the Global Burden of Disease Study

• Published in: PloS one Vol. 13; no. 2; p. e0190943
• Main Authors: Silva, Diego Augusto Santos, Tremblay, Mark Stephen, Souza, Maria de Fatima Marinho de, Mooney, Meghan, Naghavi, Mohsen, Malta, Deborah Carvalho
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.02.2018; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Age; Aged; Analysis; Biology and Life Sciences; Brazil; Brazil - epidemiology; Cancer; Cancer screening; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - epidemiology; Colorectal Neoplasms - mortality; Disabled Persons - statistics & numerical data; Exercise; Fatalities; Female; Global Burden of Disease - trends; Global Health; Health risk assessment; Humans; Male; Medicine and Health Sciences; Middle Aged; Morbidity; Mortality; Motor Activity; People and places; Physical activity; Quality-Adjusted Life Years; Risk Factors; Sedentary behavior; Silva, Mark; Socioeconomic Factors; Socioeconomics; Systematic review; Young Adult; Brazil; Malta
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0190943

The aims of this study were to estimate all-cause and cause-specific mortality and years of life lost, investigated by disability-adjusted life-years (DALYs), due to colorectal cancer attributable to physical inactivity in Brazil and in the states; to analyze the temporal trend of these estimates over 25 years (1990-2015) compared with global estimates and according to the socioeconomic status of states of Brazil. Databases from the Global Burden of Disease Study (GBD) for Brazil, Brazilian states and global information were used. It was estimated the total number and the age-standardized rates of deaths and DALYs for colorectal cancer attributable to physical inactivity in the years 1990 and 2015. We used the Socioeconomic Development Index (SDI). Physical inactivity was responsible for a substantial number of deaths (1990: 1,302; 2015: 119,351) and DALYs (1990: 31,121; 2015: 87,116) due to colorectal cancer in Brazil. From 1990 to 2015, the mortality and DALYs due to colorectal cancer attributable to physical inactivity increased in Brazil (0.6% and 0.6%, respectively) and decreased around the world (-0.8% and -1.1%, respectively). The Brazilian states with better socioeconomic indicators had higher rates of mortality and morbidity by colorectal cancer due to physical inactivity (p<0.01). Physical inactivity was responsible for deaths and DALYs due to colorectal cancer in Brazil. Over 25 years, the Brazilian population showed more worrisome results than around the world. Actions to combat physical inactivity and greater cancer screening and treatment are urgent in the Brazilian states.