Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium

• Published in: PloS one Vol. 8; no. 8; p. e71345
• Main Authors: Shah, Tina, Engmann, Jorgen, Dale, Caroline, Shah, Sonia, White, Jon, Giambartolomei, Claudia, McLachlan, Stela, Zabaneh, Delilah, Cavadino, Alana, Finan, Chris, Wong, Andrew, Amuzu, Antoinette, Ong, Ken, Gaunt, Tom, Holmes, Michael V, Warren, Helen, Swerdlow, Daniel I, Davies, Teri-Louise, Drenos, Fotios, Cooper, Jackie, Sofat, Reecha, Caulfield, Mark, Ebrahim, Shah, Lawlor, Debbie A, Talmud, Philippa J, Humphries, Steve E, Power, Christine, Hypponen, Elina, Richards, Marcus, Hardy, Rebecca, Kuh, Diana, Wareham, Nicholas, Langenberg, Claudia, Ben-Shlomo, Yoav, Day, Ian N, Whincup, Peter, Morris, Richard, Strachan, Mark W J, Price, Jacqueline, Kumari, Meena, Kivimaki, Mika, Plagnol, Vincent, Dudbridge, Frank, Whittaker, John C, Casas, Juan P, Hingorani, Aroon D
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 20.08.2013; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Aged, 80 and over; Aging; Bioindicators; Biology; Biomarkers; Cardiovascular disease; Cardiovascular Diseases - genetics; Cardiovascular Diseases - metabolism; Childrens health; Cohort analysis; Consortia; Epidemiology; Evolution; Female; Genetic aspects; Genetic Association Studies; Genetic diversity; Genetic Markers; Genetic variance; Genetics; Genome, Human; Genome-wide association studies; Genome-Wide Association Study; Genomes; Genomics; Health care; Health policy; Health sciences; Heart; Hospitals; Humans; Hygiene; Laboratories; Longitudinal Studies; Male; Medical research; Medical schools; Medicine; Metabolic Networks and Pathways - genetics; Metabolism; Metabolites; Metagenomics; Middle Aged; Oligonucleotide Array Sequence Analysis; Polymorphism; Polymorphism, Single Nucleotide; Population; Population studies; Public health; Research Design; Risk Factors; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Studies; Type 2 diabetes; Womens health; United Kingdom > UK; Scotland; Edinburgh Scotland
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0071345

Substantial advances have been made in identifying common genetic variants influencing cardiometabolic traits and disease outcomes through genome wide association studies. Nevertheless, gaps in knowledge remain and new questions have arisen regarding the population relevance, mechanisms, and applications for healthcare. Using a new high-resolution custom single nucleotide polymorphism (SNP) array (Metabochip) incorporating dense coverage of genomic regions linked to cardiometabolic disease, the University College-London School-Edinburgh-Bristol (UCLEB) consortium of highly-phenotyped population-based prospective studies, aims to: (1) fine map functionally relevant SNPs; (2) precisely estimate individual absolute and population attributable risks based on individual SNPs and their combination; (3) investigate mechanisms leading to altered risk factor profiles and CVD events; and (4) use Mendelian randomisation to undertake studies of the causal role in CVD of a range of cardiovascular biomarkers to inform public health policy and help develop new preventative therapies.