Aortic Pulse Wave Velocity Predicts Cardiovascular Mortality in Middle-Aged and Elderly Japanese Men

Background: Aortic pulse wave velocity (PWV) is widely used as a noninvasive index of arterial stiffness and was used in the present study to investigate the relationship between PWV and cardiovascular mortality in the middle-aged and elderly Japanese population using a longitudinal study design. Me...

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Published inCirculation Journal Vol. 73; no. 3; pp. 549 - 553
Main Authors Inoue, Noriko, Maeda, Ryo, Kawakami, Hideshi, Shokawa, Tomoki, Yamamoto, Hideya, Ito, Chikako, Sasaki, Hideo
Format Journal Article
LanguageEnglish
Published Japan The Japanese Circulation Society 2009
Subjects
Age Distribution
Aged
Aorta - physiology
Aortic pulse wave velocity
Arteriosclerosis
Arteriosclerosis - ethnology
Arteriosclerosis - mortality
Arteriosclerosis - physiopathology
Asian Continental Ancestry Group
Blood Flow Velocity - physiology
Blood Pressure
Cardiovascular disease
Follow-Up Studies
Humans
Male
Middle Aged
Mortality
Predictive Value of Tests
Pulsatile Flow - physiology
Risk Factors
Survival Analysis
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Summary:Background: Aortic pulse wave velocity (PWV) is widely used as a noninvasive index of arterial stiffness and was used in the present study to investigate the relationship between PWV and cardiovascular mortality in the middle-aged and elderly Japanese population using a longitudinal study design. Methods and Results: From 1988 to 2003, a total of 3,960 men (50-69 years old at baseline) who underwent medical check-ups and measurement of PWV, which was standardized for diastolic blood pressure, were recruited and divided into 4 groups according to the PWV values. The average follow-up period was 8.2 years. Mortality from all-causes and from cardiovascular disease significantly increased as PWV increased in the entire follow-up period. Multivariate-adjusted relative risks of all-cause and cardiovascular disease mortality for the highest quartile of PWV (>9.0 m/s) were 1.28 (95% confidence interval (CI) 0.97-1.68) and 1.83 (95%CI 1.02-3.29), respectively, compared with the lowest quartile (<7.5 m/s). Conclusions: An increased PWV can predict cardiovascular mortality in middle-aged and elderly Japanese men. (Circ J 2009; 73: 549 - 553)
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ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-08-0492