Combination of the Framingham Risk Score and Carotid Intima-Media Thickness Improves the Prediction of Cardiovascular Events in Patients With Type 2 Diabetes

• Published in: Diabetes care Vol. 35; no. 1; pp. 178 - 180
• Main Authors: Yoshida, Michiko, Mita, Tomoya, Yamamoto, Risako, Shimizu, Tomoaki, Ikeda, Fuki, Ohmura, Chie, Kanazawa, Akio, Hirose, Takahisa, Kawamori, Ryuzo, Watada, Hirotaka
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.01.2012
• Subjects: Adult; Aged; Ankle Brachial Index; Atherosclerosis; Biological and medical sciences; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - diagnostic imaging; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - etiology; Care and treatment; Carotid Intima-Media Thickness; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - diagnostic imaging; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Heart attacks; Historical account; Humans; Japan - epidemiology; Male; Medical sciences; Metabolic diseases; Middle Aged; Miscellaneous; Mortality; Multivariate analysis; noninsulin-dependent diabetes mellitus; Original Research; patients; Prediction; Proportional Hazards Models; Public health. Hygiene; Public health. Hygiene-occupational medicine; Research design; Retrospective Studies; risk; Risk Factors; Studies; Type 2 diabetes; Veins & arteries; Velocity; Womens health; Japan; Endocrinopathy; Type 2 diabetes; Human; Nutrition; Prediction; Patient; Metabolic diseases; Cardiovascular disease; Risk; Artery; Improvement; Blood vessel; Carotid; Risk factor; Circulatory system; Predictive factor; Vascular wall; Endocrinology
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/dc11-1333

OBJECTIVE: The aim of this study was to investigate whether carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (baPWV) add value to the Framingham risk score (FRS) in predicting the development of cardiovascular diseases (CVDs) in type 2 diabetic patients with a negative history of CVD. RESEARCH DESIGN AND METHODS: Type 2 diabetic patients (n = 783) were retrospectively recruited and followed for CVD. RESULTS: During a 5.4-year follow-up period, 85 incidences of CVD were recorded (10.9%). After adjustment for conventional arterial risk factors, multivariate analysis with the Cox proportional hazards model identified IMT, but not baPWV, as a significant determinant of CVD. In addition, the combination of FRS with IMT, but not with baPWV, improved the prediction of CVD. CONCLUSIONS: Carotid IMT is a significant predictor of CVD in asymptomatic type 2 diabetic patients, and the combination of FRS and IMT improves the prediction of CVD in these patients.