Obesity and incidence of cancer: a large cohort study of over 145 000 adults in Austria

• Published in: British journal of cancer Vol. 93; no. 9; pp. 1062 - 1067
• Main Authors: RAPP, K, SCHROEDER, J, KLENK, J, STOEHR, S, ULMER, H, CONCIN, H, DIEM, G, OBERAIGNER, W, WEILAND, S. K
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 31.10.2005
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Austria - epidemiology; Biological and medical sciences; Body Mass Index; Cohort Studies; Epidemiology; Female; Humans; Incidence; Male; Medical sciences; Metabolic diseases; Middle Aged; Neoplasms - epidemiology; Obesity; Obesity - epidemiology; Overweight; Prospective Studies; Risk Factors; Tumors; Austria; Europe; Endometrium cancer; Epidemiology; Incidence; pancreatic cancer; Colon cancer; Cancerology; non-Hodgkin; Lymphoproliferative syndrome; Cohort study; Pancreas cancer; Uterine diseases; Intestinal disease; Adult; Nutritional status; Pancreatic disease; Human; Obesity; colonic cancer; Nutrition disorder; lymphoma; Malignant hemopathy; Breast cancer; Malignant tumor; Non Hodgkin lymphoma; Female genital diseases; Colonic disease; Mammary gland diseases; endometrial cancer; Digestive diseases
• ISSN: 0007-0920; 1532-1827
• DOI: 10.1038/sj.bjc.6602819

We investigated the relation of overweight and obesity with cancer in a population-based cohort of more than 145 000 Austrian adults over an average of 9.9 years. Incident cancers (n=6241) were identified through the state cancer registry. Using Cox proportional-hazards models adjusted for smoking and occupation, increases in relative body weight in men were associated with colon cancer (hazard rate (HR) ratio 2.48; 95% confidence interval (CI): 1.15, 5.39 for body mass index (BMI) > or =35 kg m(-2)) and pancreatic cancer (HR 2.34, 95% CI: 1.17, 4.66 for BMI>30 kg m(-2)) compared to participants with normal weight (BMI 18.5-24.9 kg m(-2)). In women, there was a weak positive association between increasing BMI and all cancers combined, and strong associations with non-Hodgkin's lymphomas (HR 2.86, 95% CI: 1.49, 5.49 for BMI> or =30 kg m(-2)) and cancers of the uterine corpus (HR 3.93, 95% CI: 2.35, 6.56 for BMI> or =35 kg m(-2)). Incidence of breast cancer was positively associated with high BMI only after age 65 years. These findings provide further evidence that overweight is associated with the incidence of several types of cancer.