Serum immunoglobulin M concentration is positively related to metabolic syndrome in an adult population: Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) Cohort Study

• Published in: PloS one Vol. 9; no. 2; p. e88701
• Main Authors: Song, Kun, Du, Huanmin, Zhang, Qing, Wang, Chongjin, Guo, Yinting, Wu, Hongmei, Liu, Li, Jia, Qiyu, Wang, Xing, Shi, Hongbin, Sun, Shaomei, Niu, Kaijun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.02.2014; Public Library of Science (PLoS)
• Subjects: Adult; Adults; Age; Aged; Aged, 80 and over; Analysis; Anthropometry; Autoantigens; Autoimmune diseases; Autoimmunity; Biology; Blood Pressure; Body Mass Index; Cardiovascular disease; Cardiovascular diseases; China; Cholesterol; Cholesterol, HDL - blood; Chronic illnesses; Cohort analysis; Cohort Studies; Confidence intervals; Cross-Sectional Studies; Diabetes; Epidemiology; Fatty acids; Female; Females; Gender; Health risks; Heart; Heart diseases; Hospitals; Humans; Immunoglobulin M; Immunoglobulin M - blood; Immunoglobulins; Immunology; Inflammation; Inflammation - blood; Insulin resistance; Male; Males; Mass Spectrometry; Medical research; Medicine; Metabolic disorders; Metabolic syndrome; Metabolic Syndrome - blood; Middle Aged; Obesity; Odds Ratio; Population; Prevalence; Public health; Quality; Quartiles; Regression analysis; Risk Factors; Statistical analysis; Triglycerides; Triglycerides - blood
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0088701

Persistent low-grade systemic inflammation has been increasingly recognized as a common pathological process, and an important contributing factor to cardiovascular diseases and its risk factor, metabolic syndrome. Immunoglobulin M is reactive to multiple autoantigens and is inferred to be important for autoimmunity, implying that immunoglobulin M may be a potential risk factor for metabolic syndrome. However, few epidemiological studies are available which are related to this potential link. Therefore, we designed a cross-sectional study of 9,379 subjects to evaluate the relationship between immunoglobulin M and metabolic syndrome in an adult population. Subjects who received health examinations were recruited from the Tianjin Medical University General Hospital-Health Management Center in Tianjin, China. Immunoglobulin M was determined with an immunonephelometric technique. Metabolic syndrome was defined according to the criteria of the American Heart Association scientific statements of 2009. Multiple logistic regression analysis was used to examine the relationships between the quartiles of immunoglobulin M and the prevalence of metabolic syndrome. After adjustment for covariates, the odds ratio of having metabolic syndrome in the fourth quartile compared with the first quartile of immunoglobulin M was 1.19 times for males (95% confidence interval, 1.002-1.41) and 1.39 times for females (95% confidence interval, 1.07-1.80). Immunoglobulin M levels also showed positive relationships with the ratio of elevated triglycerides and reduced high-density lipoprotein cholesterol in males. The study is the first to show that immunoglobulin M is independently related to metabolic syndrome and its individual components (elevated triglycerides and reduced high-density lipoprotein cholesterol) in males, whereas immunoglobulin M is independently related to metabolic syndrome in females but not to its individual components. Further studies are needed to explore the causality and the exact role of immunoglobulin M in metabolic syndrome.