Primary treatment results of Nasopharyngeal Carcinoma (NPC) in Yogyakarta, Indonesia

• Published in: PloS one Vol. 8; no. 5; p. e63706
• Main Authors: Wildeman, Maarten A, Fles, Renske, Herdini, Camelia, Indrasari, Rai S, Vincent, Andrew D, Tjokronagoro, Maesadji, Stoker, Sharon, Kurnianda, Johan, Karakullukcu, Baris, Taroeno-Hariadi, Kartika W, Hamming-Vrieze, Olga, Middeldorp, Jaap M, Hariwiyanto, Bambang, Haryana, Sofia M, Tan, I Bing
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10.05.2013; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Aged; Analysis; Antigens; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biopsy; Cancer metastasis; Cancer therapies; Carcinoma; Chemotherapy; Clinical trials; Deoxyribonucleic acid; Developing countries; Diagnosis; DNA; Drug dosages; Drug therapy; Ear; Female; Head; Head & neck cancer; Head and neck cancer; Hospitals; Humans; Immunoglobulins; Indonesia; Internal medicine; LDCs; Male; Medicine; Metastases; Middle Aged; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms - mortality; Nasopharyngeal Neoplasms - pathology; Nasopharyngeal Neoplasms - therapy; Neoplasm Staging; Nose; Oncology; Otolaryngology; Patients; Pharynx; Photochemotherapy; Prognosis; Radiation therapy; Radiotherapy; Surgery; Survival; Throat cancer; Treatment Outcome; Young Adult; Indonesia
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0063706

Nasopharyngeal Carcinoma (NPC) is a major health problem in southern and eastern Asia. In Indonesia NPC is the most frequent cancer in the head and neck area. NPC is very sensitive to radiotherapy resulting in 3-year disease-free and overall survival of approximately 70% and 80%, respectively. Here we present routine treatment results in a prospective study on NPC in a top referral; university hospital in Indonesia. All NPC patients presenting from September 2008 till January 2011 at the ear, nose and throat (ENT) department of the Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia, were possible candidates. Patients were included if the biopsy was a histological proven NPC without distant metastasis and were assessed during counselling sessions prior to treatment, as being able to complete the entire treatment. In total 78 patients were included for treatment analysis. The median time between diagnosis and start of radiotherapy is 120 days. Forty-eight (62%) patients eventually finished all fractions of radiotherapy. The median duration of the radiotherapy is 62 days for 66 Gy. Median overall survival is 21 months (95% CI 18-35) from day of diagnosis. The results presented here reveal that currently the treatment of NPC at an Indonesian hospital is not sufficient and cannot be compared to the treatment results in literature. Main reasons for these poor treatment results are (1) a long waiting time prior to the start of radiotherapy, (2) the extended overall duration of radiotherapy and (3) the advanced stage of disease at presentation.