Rift Valley Fever Virus Vaccine Lacking the NSs and NSm Genes Is Safe, Nonteratogenic, and Confers Protection from Viremia, Pyrexia, and Abortion following Challenge in Adult and Pregnant Sheep

• Published in: Journal of Virology Vol. 85; no. 24; pp. 12901 - 12909
• Main Authors: BIRD, Brian H, MAARTENS, Louis H, MCELROY, Anita K, KHRISTOVA, Marina L, ALBARINO, Cesar G, NICHOL, Stuart T, CAMPBELL, Shelley, ERASMUS, Baltus J, ERICKSON, Bobbie R, DODD, Kimberly A, SPIROPOULOU, Christina F, CANNON, Deborah, DREW, Clifton P, KNUST, Barbara
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.12.2011
• Subjects: Animals; Biological and medical sciences; Congenital Abnormalities - prevention & control; Congenital Abnormalities - veterinary; Female; Fever - prevention & control; Fever - veterinary; Fundamental and applied biological sciences. Psychology; Gene Deletion; Humans; Injections, Subcutaneous; Microbiology; Miscellaneous; Pregnancy; Rift Valley Fever - prevention & control; Rift Valley Fever - veterinary; Rift Valley fever virus - genetics; Rift Valley fever virus - immunology; Sheep; Sheep Diseases - immunology; Sheep Diseases - prevention & control; Vaccines and Antiviral Agents; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; Vaccines, Attenuated - administration & dosage; Vaccines, Attenuated - adverse effects; Vaccines, Attenuated - genetics; Vaccines, Attenuated - immunology; Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - adverse effects; Vaccines, Synthetic - genetics; Vaccines, Synthetic - immunology; Viral Nonstructural Proteins - genetics; Viral Vaccines - administration & dosage; Viral Vaccines - adverse effects; Viral Vaccines - genetics; Viral Vaccines - immunology; Viremia - prevention & control; Viremia - veterinary; Virology; Pregnancy disorders; Viremia; Sandfly fever group virus; Vaccine; Abortion; Fever; Rift valley fever virus; Infection; Virus; Pregnancy; Vertebrata; Mammalia; Bunyaviridae; Gene; Viral disease; Sheep; Artiodactyla; Veterinary; Ungulata; Phlebovirus
• ISSN: 0022-538X; 1098-5514
• DOI: 10.1128/JVI.06046-11

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