SMART 4.0: towards genomic data integration
SMART (Simple Modular Architecture Research Tool) is a web tool (http://smart.embl.de/) for the identification and annotation of protein domains, and provides a platform for the comparative study of complex domain architectures in genes and proteins. The January 2004 release of SMART contains 685 pr...
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Published in | Nucleic acids research Vol. 32; no. suppl-1; pp. D142 - D144 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Oxford University Press
01.01.2004
Oxford Publishing Limited (England) |
Subjects | |
Online Access | Get full text |
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Summary: | SMART (Simple Modular Architecture Research Tool) is a web tool (http://smart.embl.de/) for the identification and annotation of protein domains, and provides a platform for the comparative study of complex domain architectures in genes and proteins. The January 2004 release of SMART contains 685 protein domains. New developments in SMART are centred on the integration of data from completed metazoan genomes. SMART now uses predicted proteins from complete genomes in its source sequence databases, and integrates these with predictions of orthology. New visualization tools have been developed to allow analysis of gene intron–exon structure within the context of protein domain structure, and to align these displays to provide schematic comparisons of orthologous genes, or multiple transcripts from the same gene. Other improvements include the ability to query SMART by Gene Ontology terms, improved structure database searching and batch retrieval of multiple entries. |
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Bibliography: | Received September 17, 2003; Revised and Accepted October 6, 2003 ark:/67375/HXZ-2TC5V52G-1 istex:5935391A02DF28167EBA429A4E9E3DAF397B5246 To whom correspondence should be addressed. Tel: +49 6221 387 526; Fax: +49 6221 387 517; Email: bork@embl‐heidelberg.de local:gkh088 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 To whom correspondence should be addressed. Tel: +49 6221 387 526; Fax: +49 6221 387 517; Email: bork@embl-heidelberg.de |
ISSN: | 0305-1048 1362-4962 1362-4962 |
DOI: | 10.1093/nar/gkh088 |