Modulatory effect of acupuncture at Waiguan (TE5) on the functional connectivity of the central nervous system of patients with ischemic stroke in the left basal ganglia

• Published in: PloS one Vol. 9; no. 6; p. e96777
• Main Authors: Chen, Junqi, Wang, Jizhou, Huang, Yong, Lai, Xinsheng, Tang, Chunzhi, Yang, Junjun, Wu, Junxian, Zeng, Tongjun, Qu, Shanshan
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.06.2014; Public Library of Science (PLoS)
• Subjects: Acupuncture; Acupuncture Therapy - methods; Basal ganglia; Basal Ganglia - physiopathology; Biology and Life Sciences; Brain; Brain Ischemia - physiopathology; Brain Ischemia - therapy; Brain mapping; Brain Mapping - methods; Central nervous system; Cerebellum; Cerebrum; Chinese medicine; Cooperation; Female; Functional magnetic resonance imaging; Ganglia; Hemispheres; Humans; Image processing; Ischemia; Magnetic resonance; Magnetic Resonance Imaging; Male; Medicine and health sciences; Middle Aged; Networks; Neural networks; Neuroimaging; Neuropsychological Tests; NMR; Nuclear magnetic resonance; Patients; Research and Analysis Methods; Sensorimotor system; Stroke; Stroke - physiopathology; Stroke - therapy; Studies; Synchronism; Synchronization; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0096777

To study the influence of acupuncture at Waiguan (TE5) on the functional connectivity of the central nervous system of patients with ischemic stroke. Twenty-four patients with ischemic stroke in the left basal ganglia were randomized based on gender to receive TE5 acupuncture (n = 12) or nonacupoint acupuncture (n = 12). Each group underwent sham acupuncture and then verum acupuncture while being scanned with functional magnetic resonance imaging. Six regions of interest (ROI) were defined, including bilateral motor, somatosensory, and bilateral basal ganglia areas. The functional connectivity between these ROIs and all voxels of the brain was analyzed in Analysis of Functional NeuroImages (AFNI) to explore the differences between verum acupuncture and sham acupuncture at TE5 and between TE5 acupuncture and nonacupoint acupuncture. The participants were blinded to the allocation. The effect of acupuncture on six seed-associated networks was explored. The result demonstrated that acupuncture at Waiguan (TE5) can regulate the sensorimotor network of the ipsilesional hemisphere, stimulate the contralesional sensorimotor network, increase cooperation of bilateral sensorimotor networks, and change the synchronization between the cerebellum and cerebrum. Furthermore, a lot of differences of effect existed between verum acupuncture and sham acupuncture at TE5, but there was little difference between TE5 acupuncture and nonacupoint acupuncture. The modulation of synchronizations between different regions within different brain networks might be the mechanism of acupuncture at Waiguan (TE5). Stimulation of the contralesional sensorimotor network and increase of cooperation of bilateral hemispheres imply a compensatory effect of the intact hemisphere, whereas changes in synchronization might influence the sensorimotor function of the affected side of the body. Chinese Clinical Trial Registry ChiCTR-ONRC-08000255.