Lung function decline is associated with serum uric acid in Korean health screening individuals

We performed a retrospective cohort study of 19,237 individuals who underwent at least three health screenings with follow-up periods of over 5 years to find a routinely checked serum marker that predicts lung function decline. Using linear regression models to analyze associations between the rate...

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Bibliographic Details
Published inScientific reports Vol. 11; no. 1; p. 10183
Main Authors Ahn, Kyung-Min, Lee, Suh-Young, Lee, So-Hee, Kim, Sun-Sin, Park, Heung-Woo
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 13.05.2021
Nature Publishing Group
Nature Portfolio
Subjects
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692/499
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Alkaline phosphatase
Aspartate aminotransferase
Bilirubin
C-reactive protein
Calcium
Cholesterol
Creatinine
Humanities and Social Sciences
Medical screening
multidisciplinary
Phosphorus
Population decline
Regression analysis
Respiratory function
Science
Science (multidisciplinary)
Smoking
Uric acid
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Summary:We performed a retrospective cohort study of 19,237 individuals who underwent at least three health screenings with follow-up periods of over 5 years to find a routinely checked serum marker that predicts lung function decline. Using linear regression models to analyze associations between the rate of decline in the forced expiratory volume in 1 s (FEV1) and the level of 10 serum markers (calcium, phosphorus, uric acid, total cholesterol, total protein, total bilirubin, alkaline phosphatase, aspartate aminotransferase, creatinine, and C-reactive protein) measured at two different times (at the first and third health screenings), we found that an increased uric acid level was significantly associated with an accelerated FEV1 decline (P = 0.0014 and P = 0.037, respectively) and reduced FEV1 predicted % (P = 0.0074 and P = 8.64 × 10 –7 , respectively) at both visits only in non-smoking individuals. In addition, we confirmed that accelerated forced vital capacity (FVC) and FEV1/FVC ratio declines were observed in non-smoking individuals with increased serum uric acid levels using linear mixed models. The serum uric acid level thus potentially predicts an acceleration in lung function decline in a non-smoking general population.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-89678-3