Effect of Sesamin on the Composition of Eicosapentaenoic Acid in Liver and on Its Lymphatic Absorption in Rats

• Published in: Bioscience, biotechnology, and biochemistry Vol. 60; no. 12; pp. 2071 - 2072
• Main Authors: Umeda-Sawada, Rumi, Ogawa, Megumi, Okada, Yuko, Igarashi, Osamu
• Format: Journal Article
• Language: English
• Published: Tokyo Taylor & Francis 1996; Japan Society for Bioscience Biotechnology and Agrochemistry; Oxford University Press
• Subjects: Animals; Anticholesteremic Agents - pharmacology; Biological and medical sciences; Biotechnology; Dioxoles - pharmacology; Eicosapentaenoic Acid - chemistry; Eicosapentaenoic Acid - metabolism; EPA; Fatty Acids - analysis; General pharmacology; Lignans; Liver - drug effects; Liver - metabolism; lymphatic absorption; Lymphatic System - drug effects; Lymphatic System - metabolism; Male; Medical sciences; n-3 fatty acid; n-6 fatty acid; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Rats; Rats, Wistar; sesamin; Rat; Liver; n-3 fatty acid; Medicinal plant; Absorption; Dicotyledones; Angiospermae; Sesame oil; Lignan; Food; Pharmacognosy; Rodentia; Polyunsaturated fatty acid; Sesamum indicum; Pedaliaceae; Metabolism; Biological activity; Vertebrata; Mammalia; n-6 fatty acid; β Oxidation; Animal; Plant origin; Spermatophyta; Lymph
• ISSN: 0916-8451; 1347-6947
• DOI: 10.1271/bbb.60.2071

Changes in the hepatic concentration of n-3 fatty acids, e.g., eicosapentaenoic acid and linolenic acid, were significantly reduced by their simultaneous administration with sesamin, whereas there was no such effect of sesamin for n-6 and n-9 fatty acids. However, there was no significant difference in lymphatic absorption between eicosapentaenoic acid (n-3) and arachidonic acid (n-6), irrespective of the presence or absence of sesamin.