Gene Expression Patterns in Human Embryonic Stem Cells and Human Pluripotent Germ Cell Tumors

Remarkably little is known about the transcriptional profiles of human embryonic stem (ES) cells or the molecular mechanisms that underlie their pluripotency. To identify commonalties among the transcriptional profiles of different human pluripotent cells and to search for clues into the genesis of...

Full description

Saved in:
Bibliographic Details
Published inProceedings of the National Academy of Sciences - PNAS Vol. 100; no. 23; pp. 13350 - 13355
Main Authors Sperger, Jamie M., Chen, Xin, Draper, Jonathan S., Antosiewicz, Jessica E., Chon, Chris H., Jones, Sunita B., Brooks, James D., Andrews, Peter W., Brown, Patrick O., Thomson, James A.
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences 11.11.2003
National Acad Sciences
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Remarkably little is known about the transcriptional profiles of human embryonic stem (ES) cells or the molecular mechanisms that underlie their pluripotency. To identify commonalties among the transcriptional profiles of different human pluripotent cells and to search for clues into the genesis of human germ cell tumors, we compared the expression profiles of human ES cell lines, human germ cell tumor cell lines and tumor samples, somatic cell lines, and testicular tissue samples by using cDNA microarray analysis. Hierarchical cluster analysis of gene expression profiles showed that the five independent human ES cell lines clustered tightly together, reflecting highly similar expression profiles. The gene expression patterns of human ES cell lines showed many similarities with the human embryonal carcinoma cell samples and more distantly with the seminoma samples. We identified 895 genes that were expressed at significantly greater levels in human ES and embryonal carcinoma cell lines than in control samples. These genes are candidates for involvement in the maintenance of a pluripotent, undifferentiated phenotype.
AbstractList Remarkably little is known about the transcriptional profiles of human embryonic stem (ES) cells or the molecular mechanisms that underlie their pluripotency. To identify commonalties among the transcriptional profiles of different human pluripotent cells and to search for clues into the genesis of human germ cell tumors, we compared the expression profiles of human ES cell lines, human germ cell tumor cell lines and tumor samples, somatic cell lines, and testicular tissue samples by using cDNA microarray analysis. Hierarchical cluster analysis of gene expression profiles showed that the five independent human ES cell lines clustered tightly together, reflecting highly similar expression profiles. The gene expression patterns of human ES cell lines showed many similarities with the human embryonal carcinoma cell samples and more distantly with the seminoma samples. We identified 895 genes that were expressed at significantly greater levels in human ES and embryonal carcinoma cell lines than in control samples. These genes are candidates for involvement in the maintenance of a pluripotent, undifferentiated phenotype.
Remarkably little is known about the transcriptional profiles of human embryonic stem (ES) cells or the molecular mechanisms that underlie their pluripotency. To identify commonalties among the transcriptional profiles of different human pluripotent cells and to search for clues into the genesis of human germ cell tumors, we compared the expression profiles of human ES cell lines, human germ cell tumor cell lines and tumor samples, somatic cell lines, and testicular tissue samples by using cDNA microarray analysis. Hierarchical cluster analysis of gene expression profiles showed that the five independent human ES cell lines clustered tightly together, reflecting highly similar expression profiles. The gene expression patterns of human ES cell lines showed many similarities with the human embryonal carcinoma cell samples and more distantly with the seminoma samples. We identified 895 genes that were expressed at significantly greater levels in human ES and embryonal carcinoma cell lines than in control samples. These genes are candidates for involvement in the maintenance of a pluripotent, undifferentiated phenotype. [PUBLICATION ABSTRACT]
Author Thomson, James A.
Chen, Xin
Draper, Jonathan S.
Andrews, Peter W.
Sperger, Jamie M.
Antosiewicz, Jessica E.
Chon, Chris H.
Brooks, James D.
Jones, Sunita B.
Brown, Patrick O.
AuthorAffiliation Wisconsin National Primate Research Center and †† Department of Anatomy, School of Medicine, University of Wisconsin, Madison, WI 53715; ‡ Howard Hughes Medical Institute, Departments of ¶ Urology and ∥ Biochemistry, Stanford University School of Medicine, Stanford, CA 94305; and § Department of Biomedical Science, University of Sheffield, Sheffield S10 27N, United Kingdom
AuthorAffiliation_xml – name: Wisconsin National Primate Research Center and †† Department of Anatomy, School of Medicine, University of Wisconsin, Madison, WI 53715; ‡ Howard Hughes Medical Institute, Departments of ¶ Urology and ∥ Biochemistry, Stanford University School of Medicine, Stanford, CA 94305; and § Department of Biomedical Science, University of Sheffield, Sheffield S10 27N, United Kingdom
Author_xml – sequence: 1
  givenname: Jamie M.
  surname: Sperger
  fullname: Sperger, Jamie M.
– sequence: 2
  givenname: Xin
  surname: Chen
  fullname: Chen, Xin
– sequence: 3
  givenname: Jonathan S.
  surname: Draper
  fullname: Draper, Jonathan S.
– sequence: 4
  givenname: Jessica E.
  surname: Antosiewicz
  fullname: Antosiewicz, Jessica E.
– sequence: 5
  givenname: Chris H.
  surname: Chon
  fullname: Chon, Chris H.
– sequence: 6
  givenname: Sunita B.
  surname: Jones
  fullname: Jones, Sunita B.
– sequence: 7
  givenname: James D.
  surname: Brooks
  fullname: Brooks, James D.
– sequence: 8
  givenname: Peter W.
  surname: Andrews
  fullname: Andrews, Peter W.
– sequence: 9
  givenname: Patrick O.
  surname: Brown
  fullname: Brown, Patrick O.
– sequence: 10
  givenname: James A.
  surname: Thomson
  fullname: Thomson, James A.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/14595015$$D View this record in MEDLINE/PubMed
BookMark eNqFkUFv1DAQhS1URLeFMxeELA5IHLadseMkPvSAVssWqRKVKEdkOYkDWSV2sB3U_nscbdQFLj35MN97njfvjJxYZw0hrxEuEAp-OVodLhjjouACAZ6RFYLEdZ5JOCErAFasy4xlp-QshD0ASFHCC3KKmZACUKzI952xhm7vR29C6JyltzpG422gnaXX06At3Q6Vf3C2q-nXaAa6MX0fqLbNMr7tJ9-NLhob6c74A0DvpsH58JI8b3UfzKvlPSffPm3vNtfrmy-7z5uPN-taSBbXrS6xlrJhTdNURSVMgzXWhWxL0erK5LxuMo5ctCgwzyvDmBS81FVVAmNNyn5Org6-41QNpqnTLl73avTdoP2DcrpT_05s91P9cL8Vy3mJs_79ovfu12RCVEMX6pRDW-OmoArkOc9L8SSIkuUM2ez47j9w7yZv0xEUA-QcRM4TdHmAau9C8KZ93BhBzf2quV917Dcp3v4d9MgvhSbgwwLMyqMdKMZV-leAaqe-j-Y-JpY-wSbkzQHZh-j8I8MxKzHj_A9TNcWS
CitedBy_id crossref_primary_10_1182_blood_2004_02_0502
crossref_primary_10_1016_j_humpath_2016_08_002
crossref_primary_10_1038_nbt0705_795
crossref_primary_10_1002_stem_99
crossref_primary_10_1089_scd_2013_0220
crossref_primary_10_1007_s12033_008_9118_8
crossref_primary_10_1111_j_1432_0436_2006_00143_x
crossref_primary_10_1016_j_humpath_2005_09_021
crossref_primary_10_1196_annals_1349_004
crossref_primary_10_3389_fgene_2018_00623
crossref_primary_10_1016_j_bbrc_2006_08_175
crossref_primary_10_1371_journal_pgen_1005415
crossref_primary_10_1634_stemcells_2005_0604
crossref_primary_10_1002_wsbm_1182
crossref_primary_10_1007_s40495_016_0054_1
crossref_primary_10_1016_j_joen_2017_12_007
crossref_primary_10_1038_nrc3034
crossref_primary_10_1089_scd_2008_0335
crossref_primary_10_1186_s13046_016_0452_6
crossref_primary_10_1093_icb_icab169
crossref_primary_10_1002_jcb_20284
crossref_primary_10_1186_1755_8794_4_46
crossref_primary_10_1093_humrep_deq144
crossref_primary_10_1038_s41419_018_1021_z
crossref_primary_10_1196_annals_1334_007
crossref_primary_10_1093_carcin_bgx036
crossref_primary_10_1073_pnas_0712136105
crossref_primary_10_1074_jbc_M504772200
crossref_primary_10_1152_physiolgenomics_00130_2014
crossref_primary_10_1128_MCB_24_3_1168_1173_2004
crossref_primary_10_1016_j_jbc_2021_100495
crossref_primary_10_1002_wsbm_93
crossref_primary_10_1038_ng_127
crossref_primary_10_1016_j_ydbio_2005_06_008
crossref_primary_10_1186_s12918_018_0525_6
crossref_primary_10_1002_mrd_21077
crossref_primary_10_1038_mt_2009_287
crossref_primary_10_1038_s41598_018_30881_0
crossref_primary_10_1016_j_ydbio_2006_01_023
crossref_primary_10_1111_j_1365_2605_2007_00758_x
crossref_primary_10_1017_erm_2013_13
crossref_primary_10_1186_1471_213X_4_10
crossref_primary_10_1002_pmic_201000407
crossref_primary_10_1359_jbmr_081010
crossref_primary_10_1016_j_bbrc_2007_01_138
crossref_primary_10_1158_0008_5472_CAN_05_2936
crossref_primary_10_1007_s12015_014_9580_6
crossref_primary_10_1007_s10059_011_0039_1
crossref_primary_10_1186_1471_2164_11_132
crossref_primary_10_4161_cam_2_1_5884
crossref_primary_10_3389_fendo_2019_00417
crossref_primary_10_1089_scd_2013_0262
crossref_primary_10_1371_journal_pone_0017538
crossref_primary_10_1158_0008_5472_CAN_07_5560
crossref_primary_10_1097_IAE_0000000000002449
crossref_primary_10_1097_01_pas_0000213320_04919_1a
crossref_primary_10_1002_jcb_24229
crossref_primary_10_1002_stem_1542
crossref_primary_10_1007_s12015_008_9038_9
crossref_primary_10_1177_1091581812446869
crossref_primary_10_1038_modpathol_2009_66
crossref_primary_10_1093_humrep_dep126
crossref_primary_10_1002_bit_24396
crossref_primary_10_1089_omi_2013_0084
crossref_primary_10_1016_j_bbamem_2011_09_018
crossref_primary_10_1093_humrep_deh529
crossref_primary_10_1111_j_1365_2605_2005_00643_x
crossref_primary_10_1016_j_exphem_2005_03_002
crossref_primary_10_1186_scrt185
crossref_primary_10_1128_JVI_00965_15
crossref_primary_10_1002_cam4_2195
crossref_primary_10_1101_gr_073460_107
crossref_primary_10_3390_genes14030745
crossref_primary_10_1021_acsbiomaterials_0c01462
crossref_primary_10_1158_0008_5472_CAN_06_0031
crossref_primary_10_1371_journal_pone_0053003
crossref_primary_10_1007_s00428_019_02560_6
crossref_primary_10_1016_j_brainres_2008_07_029
crossref_primary_10_4161_cc_11_5_19450
crossref_primary_10_1038_nrc3021
crossref_primary_10_1038_pcan_2013_57
crossref_primary_10_1007_s00120_009_1948_x
crossref_primary_10_1038_sj_onc_1208755
crossref_primary_10_1016_j_yexcr_2013_11_024
crossref_primary_10_1111_rda_12619
crossref_primary_10_1634_stemcells_2005_0304
crossref_primary_10_1002_stem_1200
crossref_primary_10_1042_CS20070388
crossref_primary_10_1186_s13024_018_0275_3
crossref_primary_10_1371_journal_pgen_0020011
crossref_primary_10_3389_fendo_2019_00408
crossref_primary_10_1038_s41598_019_45573_6
crossref_primary_10_1111_j_1439_0531_2012_02060_x
crossref_primary_10_1186_1471_2164_6_99
crossref_primary_10_1016_j_leukres_2008_06_011
crossref_primary_10_1634_stemcells_2007_0286
crossref_primary_10_3389_fmed_2021_756029
crossref_primary_10_1002_biot_201100347
crossref_primary_10_1101_gad_313104
crossref_primary_10_1002_gcc_20562
crossref_primary_10_1002_path_1766
crossref_primary_10_1111_j_1600_0897_2005_00354_x
crossref_primary_10_1002_pmic_200900483
crossref_primary_10_1093_hmg_ddi083
crossref_primary_10_1093_hmg_ddl112
crossref_primary_10_1016_j_stemcr_2013_03_004
crossref_primary_10_3390_cells8121500
crossref_primary_10_1007_s11033_009_9530_6
crossref_primary_10_1016_j_bpobgyn_2004_07_004
crossref_primary_10_1371_journal_pone_0039088
crossref_primary_10_1093_humupd_dml041
crossref_primary_10_1007_s00428_021_03168_5
crossref_primary_10_3390_ijms24044148
crossref_primary_10_1309_LM0QFESYMX42NLXB
crossref_primary_10_1186_1471_2199_12_37
crossref_primary_10_3889_oamjms_2016_008
crossref_primary_10_2217_17460751_3_6_817
crossref_primary_10_1038_onc_2009_89
crossref_primary_10_1038_s41598_018_34845_2
crossref_primary_10_1371_journal_pone_0001149
crossref_primary_10_1007_s40495_018_0143_4
crossref_primary_10_1016_j_yexcr_2016_08_026
crossref_primary_10_1634_stemcells_2005_0439
crossref_primary_10_1371_journal_pone_0056893
crossref_primary_10_1016_j_tibtech_2004_10_001
crossref_primary_10_1128_MCB_01970_08
crossref_primary_10_1038_sj_gt_3302651
crossref_primary_10_1016_j_celrep_2014_10_013
crossref_primary_10_1111_j_1365_2605_2011_01157_x
crossref_primary_10_1002_jcp_22214
crossref_primary_10_1016_j_abb_2012_03_008
crossref_primary_10_1080_19382014_2016_1182276
crossref_primary_10_1095_biolreprod_106_053868
crossref_primary_10_1111_j_1365_2605_2011_01169_x
crossref_primary_10_1186_1471_213X_7_12
crossref_primary_10_3390_ijms232012063
crossref_primary_10_1073_pnas_0707210104
crossref_primary_10_1186_1471_213X_6_40
crossref_primary_10_1016_j_molcel_2019_03_014
crossref_primary_10_1002_stem_1526
crossref_primary_10_1007_s12015_010_9153_2
crossref_primary_10_1007_s00109_020_01960_5
crossref_primary_10_1038_bjc_2013_727
crossref_primary_10_1038_sj_bjc_6604079
crossref_primary_10_1002_stem_1870
crossref_primary_10_1016_j_bbrc_2005_08_055
crossref_primary_10_1634_stemcells_2007_0372
crossref_primary_10_1002_path_2522
crossref_primary_10_1002_ejlt_201200044
crossref_primary_10_1002_jcb_22084
crossref_primary_10_1002_jcp_22464
crossref_primary_10_1158_0008_5472_CAN_15_1790
crossref_primary_10_4161_cc_9_22_13743
crossref_primary_10_1007_s00418_010_0710_1
crossref_primary_10_1369_0022155411400606
crossref_primary_10_1038_nature06027
crossref_primary_10_1093_jmcb_mjy013
crossref_primary_10_1007_s11434_014_0131_y
crossref_primary_10_1248_bpb_b16_00299
crossref_primary_10_1016_j_cell_2008_05_047
crossref_primary_10_1016_j_urolonc_2009_06_010
crossref_primary_10_1016_j_cell_2011_08_038
crossref_primary_10_1111_j_1365_2990_2009_01008_x
crossref_primary_10_3390_data7050064
crossref_primary_10_1016_j_jprot_2013_11_010
crossref_primary_10_1016_j_isci_2022_104844
crossref_primary_10_1007_s00441_005_1084_x
crossref_primary_10_1007_s11033_022_08166_7
crossref_primary_10_1038_sj_onc_1208694
crossref_primary_10_1016_j_scr_2012_09_002
crossref_primary_10_1089_cell_2016_0008
crossref_primary_10_1186_gb_2012_13_8_r71
crossref_primary_10_1242_jcs_016964
crossref_primary_10_1016_j_tibtech_2007_09_003
crossref_primary_10_1016_S0140_6736_03_15245_2
crossref_primary_10_1098_rsif_2010_0353_focus
crossref_primary_10_1016_j_stem_2008_07_001
crossref_primary_10_1038_sj_onc_1208228
crossref_primary_10_1016_j_bbrc_2016_08_157
crossref_primary_10_1016_j_ajpath_2011_12_015
crossref_primary_10_1038_nrm1713
crossref_primary_10_1371_journal_pone_0109921
crossref_primary_10_1158_0008_5472_CAN_11_2209
crossref_primary_10_1186_1471_2407_9_383
crossref_primary_10_3389_fimmu_2019_01510
crossref_primary_10_1634_stemcells_2005_0113
crossref_primary_10_1097_WNR_0000000000000284
crossref_primary_10_1100_2012_843843
crossref_primary_10_1111_1759_7714_13440
crossref_primary_10_4306_pi_2015_12_1_81
crossref_primary_10_1002_path_1587
crossref_primary_10_1016_j_molcel_2012_08_030
crossref_primary_10_1038_cddis_2015_383
crossref_primary_10_1634_stemcells_2005_0143
crossref_primary_10_3390_biomedicines1010049
crossref_primary_10_1038_ng_600
crossref_primary_10_1016_j_toxlet_2011_09_003
crossref_primary_10_1056_NEJMra1407550
crossref_primary_10_1002_pros_22497
crossref_primary_10_1016_j_bbamcr_2014_07_013
crossref_primary_10_1182_blood_2007_03_082586
crossref_primary_10_1134_S1062360408060015
crossref_primary_10_1016_j_ygeno_2006_09_010
crossref_primary_10_1093_stcltm_szac039
crossref_primary_10_1186_1471_213X_7_46
crossref_primary_10_1038_nrm1938
crossref_primary_10_1186_1471_2164_15_711
crossref_primary_10_1016_j_exphem_2007_04_010
crossref_primary_10_1016_S0140_6736_04_16649_X
crossref_primary_10_1007_s12015_007_0002_x
crossref_primary_10_1016_j_taap_2009_12_021
crossref_primary_10_1074_jbc_M109_052290
crossref_primary_10_1089_scd_2016_0081
crossref_primary_10_1158_0008_5472_CAN_08_4953
crossref_primary_10_1186_1756_0500_4_471
crossref_primary_10_1002_cyto_b_20044
crossref_primary_10_1093_humupd_dmk006
crossref_primary_10_1016_j_bbrc_2017_04_059
crossref_primary_10_1038_nmeth744
crossref_primary_10_1002_jcb_27374
crossref_primary_10_1196_annals_1411_000
crossref_primary_10_1016_S0140_6736_06_68305_0
crossref_primary_10_1096_fj_04_2417fje
crossref_primary_10_1016_j_scr_2016_03_007
crossref_primary_10_1002_gcc_20160
crossref_primary_10_3389_fmicb_2018_01253
crossref_primary_10_1371_journal_pone_0019198
crossref_primary_10_1517_14728222_2014_940894
crossref_primary_10_1038_nature09209
crossref_primary_10_3390_ijms232112992
crossref_primary_10_1016_j_tiv_2010_05_017
crossref_primary_10_1158_0008_5472_CAN_04_0679
crossref_primary_10_1016_j_scr_2016_03_002
crossref_primary_10_1089_cell_2014_0098
crossref_primary_10_1016_j_bbapap_2007_07_017
crossref_primary_10_1634_stemcells_2004_0303
crossref_primary_10_1196_annals_1411_013
crossref_primary_10_1038_ncomms5825
crossref_primary_10_3390_medicina59040724
crossref_primary_10_1016_j_semcancer_2008_03_020
crossref_primary_10_1089_scd_2006_15_200
crossref_primary_10_1016_j_bbrc_2006_12_025
crossref_primary_10_1111_j_1365_2605_2007_00762_x
crossref_primary_10_1111_j_1365_3016_2006_00766_x
crossref_primary_10_1007_s10142_005_0132_7
crossref_primary_10_1021_acs_jproteome_9b00007
crossref_primary_10_1038_nrm3584
crossref_primary_10_1152_physrev_00054_2003
crossref_primary_10_1016_j_devcel_2005_10_017
crossref_primary_10_1002_path_2230
crossref_primary_10_1634_stemcells_2005_0185
crossref_primary_10_1095_biolreprod_107_066175
crossref_primary_10_1128_MCB_05067_11
crossref_primary_10_1158_0008_5472_CAN_10_4402
crossref_primary_10_1002_mrd_20417
crossref_primary_10_1016_j_stemcr_2015_04_009
crossref_primary_10_1620_tjem_212_177
crossref_primary_10_1093_nar_gkv529
crossref_primary_10_1089_scd_2006_15_532
crossref_primary_10_1134_S0012496606010340
crossref_primary_10_1002_stem_562
crossref_primary_10_1093_jmcb_mjs029
crossref_primary_10_1158_0008_5472_CAN_21_1452
crossref_primary_10_1016_j_scr_2010_06_002
crossref_primary_10_1038_bjc_2014_128
crossref_primary_10_1007_BF02698058
crossref_primary_10_1089_cell_2010_0067
crossref_primary_10_1111_j_1365_2605_2011_01213_x
crossref_primary_10_1186_1479_5876_7_20
crossref_primary_10_1038_nbt1102
crossref_primary_10_1371_journal_pone_0188854
crossref_primary_10_1016_j_bbrc_2005_11_149
crossref_primary_10_5966_sctm_2012_0163
crossref_primary_10_1074_mcp_M110_000679
crossref_primary_10_1371_journal_pone_0048677
crossref_primary_10_1182_blood_2004_10_3975
crossref_primary_10_1210_er_2005_0016
crossref_primary_10_1634_stemcells_2005_0093
crossref_primary_10_3389_fgene_2019_00766
crossref_primary_10_1089_scd_2007_0070
crossref_primary_10_1172_JCI40583
crossref_primary_10_3390_cells10123447
crossref_primary_10_1016_j_humpath_2018_09_007
crossref_primary_10_7759_cureus_26527
crossref_primary_10_3109_00313021003767355
crossref_primary_10_1073_pnas_0813139106
crossref_primary_10_1161_CIRCRESAHA_111_249037
crossref_primary_10_1016_j_mad_2006_11_005
crossref_primary_10_1016_j_gene_2013_09_011
crossref_primary_10_1016_j_chembiol_2023_06_004
crossref_primary_10_1016_S1016_8478_23_12862_7
crossref_primary_10_1089_scd_2005_14_270
crossref_primary_10_1158_0008_5472_CAN_05_2445
crossref_primary_10_1016_j_bios_2013_01_019
crossref_primary_10_1089_scd_2005_14_395
crossref_primary_10_4161_cam_3_4_9913
crossref_primary_10_1111_j_1399_543X_2004_00074_x
crossref_primary_10_1088_1478_3975_9_2_024001
crossref_primary_10_1016_j_ydbio_2004_08_013
crossref_primary_10_1038_nrg2046
crossref_primary_10_1242_dev_156612
crossref_primary_10_3389_fonc_2018_00594
crossref_primary_10_1111_j_1365_2443_2008_01268_x
crossref_primary_10_1093_bfgp_elt011
crossref_primary_10_1016_j_bbaexp_2005_08_006
crossref_primary_10_1371_journal_pone_0019386
crossref_primary_10_1095_biolreprod_104_030395
crossref_primary_10_1016_j_jbc_2023_104843
crossref_primary_10_1089_scd_2012_0369
crossref_primary_10_1634_stemcells_2004_0341
crossref_primary_10_1007_s12015_011_9317_8
crossref_primary_10_1002_1873_3468_12935
crossref_primary_10_1634_stemcells_2006_0075
crossref_primary_10_1186_1471_2121_10_44
crossref_primary_10_1038_s41598_019_48396_7
crossref_primary_10_1016_j_scr_2018_07_009
crossref_primary_10_1002_gcc_22002
crossref_primary_10_1093_hmg_ddt571
crossref_primary_10_3389_fcell_2016_00134
crossref_primary_10_1002_bit_20245
crossref_primary_10_1158_0008_5472_CAN_05_0153
crossref_primary_10_1093_hmg_ddi345
crossref_primary_10_1186_1471_2164_12_29
crossref_primary_10_1371_journal_pone_0029170
crossref_primary_10_1016_j_bbrc_2021_04_002
crossref_primary_10_1038_nbt1318
crossref_primary_10_1146_annurev_bioeng_071811_150120
crossref_primary_10_1089_cell_2010_0097
crossref_primary_10_1016_j_ejcb_2013_11_006
crossref_primary_10_3390_biology12060888
crossref_primary_10_1016_j_bbrc_2004_08_117
crossref_primary_10_1186_1752_0509_7_S6_S10
crossref_primary_10_1111_j_1474_9728_2004_00134_x
crossref_primary_10_4161_cc_23285
crossref_primary_10_1016_j_biomaterials_2013_05_050
crossref_primary_10_1016_j_stem_2009_06_002
crossref_primary_10_1016_j_exphem_2007_06_004
crossref_primary_10_1016_j_clon_2018_01_009
crossref_primary_10_1038_sj_bjc_6602560
crossref_primary_10_1186_s13148_018_0559_z
crossref_primary_10_1634_stemcells_2006_0054
crossref_primary_10_18632_oncotarget_2215
crossref_primary_10_1002_ijc_27963
crossref_primary_10_1016_j_canlet_2011_02_004
crossref_primary_10_1128_MCB_00099_14
crossref_primary_10_1111_j_1600_0463_2005_apm_312_x
crossref_primary_10_1093_jmcb_mjaa024
crossref_primary_10_1634_stemcells_2004_0157
crossref_primary_10_1097_PAS_0b013e31802e708a
crossref_primary_10_3390_cancers13205223
crossref_primary_10_3390_cancers13102349
crossref_primary_10_1007_s00428_005_1257_8
crossref_primary_10_1073_pnas_0509082102
crossref_primary_10_2217_17460751_1_1_103
crossref_primary_10_1111_j_1365_2605_2011_01161_x
crossref_primary_10_1074_jbc_RA119_007386
crossref_primary_10_1159_000092324
crossref_primary_10_1002_med_21284
crossref_primary_10_1039_b506803g
crossref_primary_10_1002_path_2064
crossref_primary_10_1039_C8AN01739E
crossref_primary_10_1111_j_1464_410X_2009_08855_x
crossref_primary_10_1089_scd_2004_13_694
crossref_primary_10_1371_journal_pone_0071113
crossref_primary_10_1002_jcp_21714
crossref_primary_10_1016_j_febslet_2012_08_013
crossref_primary_10_1038_s41419_019_1493_5
crossref_primary_10_1002_pbc_23282
crossref_primary_10_1073_pnas_1323697111
crossref_primary_10_1016_j_cbpa_2007_05_029
crossref_primary_10_1016_j_bbrc_2007_12_013
crossref_primary_10_5966_sctm_2012_0106
crossref_primary_10_1002_stem_182
crossref_primary_10_1007_s00109_008_0356_9
crossref_primary_10_1093_carcin_bgy054
crossref_primary_10_1186_1471_2164_7_103
crossref_primary_10_1021_cb700032u
crossref_primary_10_3389_fgene_2021_613808
crossref_primary_10_1016_j_febslet_2006_01_095
crossref_primary_10_1101_gr_201293_115
crossref_primary_10_1016_j_scr_2009_09_003
crossref_primary_10_1182_blood_2014_03_562694
crossref_primary_10_4252_wjsc_v6_i5_598
crossref_primary_10_1007_s11626_010_9297_z
crossref_primary_10_1007_s00018_019_03022_7
crossref_primary_10_1158_1078_0432_CCR_09_3338
crossref_primary_10_1016_j_cell_2005_02_018
crossref_primary_10_1007_s00441_007_0536_x
crossref_primary_10_1634_stemcells_2006_0271
crossref_primary_10_1134_S1022795408030010
crossref_primary_10_1371_journal_pone_0016174
crossref_primary_10_1371_journal_pone_0051563
crossref_primary_10_1038_mt_2015_100
crossref_primary_10_1158_0008_5472_CAN_09_1490
crossref_primary_10_1002_cncr_21435
crossref_primary_10_1016_j_gep_2014_07_002
crossref_primary_10_1016_j_scr_2008_06_001
crossref_primary_10_1002_cncr_21432
crossref_primary_10_2350_08_05_0097_1
crossref_primary_10_1371_journal_pone_0088965
crossref_primary_10_1071_RD14071
crossref_primary_10_1177_014107680509800804
crossref_primary_10_1016_j_cca_2006_12_016
crossref_primary_10_1016_j_clgc_2013_04_015
crossref_primary_10_1111_j_1600_0463_2007_apm_660_xml_x
crossref_primary_10_1007_s12015_011_9300_4
crossref_primary_10_3748_wjg_v10_i9_1246
crossref_primary_10_1016_j_scr_2017_04_006
crossref_primary_10_1039_c3an00321c
crossref_primary_10_1634_stemcells_2006_0247
crossref_primary_10_1002_gene_20078
crossref_primary_10_1371_journal_pone_0021861
crossref_primary_10_1002_pro_2547
crossref_primary_10_1016_j_stemcr_2016_04_002
crossref_primary_10_1002_stem_189
crossref_primary_10_1155_2018_7396905
crossref_primary_10_1016_j_mce_2008_02_018
crossref_primary_10_3727_096368912X655208
crossref_primary_10_1002_ar_22592
crossref_primary_10_1038_nrc1568
crossref_primary_10_1002_pros_20982
crossref_primary_10_1634_stemcells_2004_0189
crossref_primary_10_3390_life11070629
crossref_primary_10_18632_oncotarget_5787
crossref_primary_10_1634_stemcells_2006_0236
crossref_primary_10_2217_epi_09_19
crossref_primary_10_1111_j_1365_2605_2011_01170_x
crossref_primary_10_1038_nbt1285
crossref_primary_10_1634_stemcells_2006_0352
crossref_primary_10_1634_stemcells_2006_0232
crossref_primary_10_4161_idp_29997
crossref_primary_10_1242_dev_01451
crossref_primary_10_1073_pnas_0712018105
crossref_primary_10_1089_scd_2009_0426
crossref_primary_10_7554_eLife_18541
crossref_primary_10_1002_stem_37
crossref_primary_10_1091_mbc_e05_11_1024
crossref_primary_10_1634_stemcells_22_5_861
crossref_primary_10_1038_nbt1177
crossref_primary_10_3727_096368915X686832
crossref_primary_10_1158_1078_0432_CCR_17_3177
crossref_primary_10_1007_s00701_016_3064_1
crossref_primary_10_1038_sj_emboj_7600749
crossref_primary_10_1158_1535_7163_MCT_17_0421
crossref_primary_10_1530_REP_16_0586
crossref_primary_10_1016_j_celrep_2012_10_017
crossref_primary_10_1111_j_1349_7006_2008_00987_x
crossref_primary_10_1158_0008_5472_CAN_06_1863
crossref_primary_10_1002_cbic_201700100
crossref_primary_10_1016_j_gene_2018_03_072
crossref_primary_10_1634_stemcells_2004_0162
crossref_primary_10_1186_1471_2164_8_478
crossref_primary_10_1016_j_bbagrm_2014_08_005
Cites_doi 10.1038/35021093
10.1101/gad.1020502
10.1006/dbio.2000.9912
10.1101/gad.966002
10.1074/jbc.271.38.23126
10.1101/gad.9.21.2635
10.1038/ng1045
10.1126/science.1073823
10.1038/nbt761
10.1038/sj.onc.1206302
10.1073/pnas.78.12.7634
10.1002/(SICI)1520-6408(1996)19:1<51::AID-DVG6>3.0.CO;2-#
10.1016/S0012-1606(03)00256-2
10.1002/ijc.2910290507
10.1101/gad.12.13.2048
10.1038/sj.onc.1203950
10.1002/j.1460-2075.1989.tb08393.x
10.1002/(SICI)1521-1878(199809)20:9<722::AID-BIES5>3.0.CO;2-I
10.1073/pnas.091062498
10.1016/B978-1-4831-9953-5.50005-6
10.1038/nature00927
10.1016/B978-0-12-333530-2.50021-6
10.1634/stemcells.20-4-329
10.1038/nbt788
10.1038/74199
10.1101/gad.224503
10.1038/292154a0
10.1016/0012-1606(92)90174-F
10.1093/nar/gkg014
10.1126/science.1072530
10.1016/S0960-9822(01)00144-0
10.1016/S0092-8674(00)81769-9
10.1159/000474691
10.1073/pnas.95.25.14863
10.1634/stemcells.21-1-111
10.1111/j.1432-0436.1989.tb00602.x
10.1016/0092-8674(92)90317-6
10.1126/science.282.5391.1145
10.1038/35000501
10.1016/S0092-8674(03)00392-1
10.1016/S0925-4773(02)00242-3
10.1006/dbio.1997.8777
10.1002/ijc.2910400309
10.1002/ijc.2910260304
10.1002/1097-0142(19850601)55:11<2584::AID-CNCR2820551110>3.0.CO;2-B
10.1016/S0092-8674(03)00393-3
ContentType Journal Article
Copyright Copyright 1993-2003 National Academy of Sciences of the United States of America
Copyright National Academy of Sciences Nov 11, 2003
Copyright © 2003, The National Academy of Sciences 2003
Copyright_xml – notice: Copyright 1993-2003 National Academy of Sciences of the United States of America
– notice: Copyright National Academy of Sciences Nov 11, 2003
– notice: Copyright © 2003, The National Academy of Sciences 2003
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7QG
7QL
7QP
7QR
7SN
7SS
7T5
7TK
7TM
7TO
7U9
8FD
C1K
FR3
H94
M7N
P64
RC3
7X8
5PM
DOI 10.1073/pnas.2235735100
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Immunology Abstracts
Neurosciences Abstracts
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Virology and AIDS Abstracts
Technology Research Database
Environmental Sciences and Pollution Management
Engineering Research Database
AIDS and Cancer Research Abstracts
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biotechnology and BioEngineering Abstracts
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Virology and AIDS Abstracts
Oncogenes and Growth Factors Abstracts
Technology Research Database
Nucleic Acids Abstracts
Ecology Abstracts
Neurosciences Abstracts
Biotechnology and BioEngineering Abstracts
Environmental Sciences and Pollution Management
Entomology Abstracts
Genetics Abstracts
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
AIDS and Cancer Research Abstracts
Chemoreception Abstracts
Immunology Abstracts
Engineering Research Database
Calcium & Calcified Tissue Abstracts
MEDLINE - Academic
DatabaseTitleList Genetics Abstracts
MEDLINE - Academic
MEDLINE



Virology and AIDS Abstracts
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Sciences (General)
Biology
EISSN 1091-6490
EndPage 13355
ExternalDocumentID 671926431
10_1073_pnas_2235735100
14595015
100_23_13350
3148143
Genre Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S
Journal Article
Feature
GrantInformation_xml – fundername: Wellcome Trust
GroupedDBID ---
-DZ
-~X
.55
.GJ
0R~
123
29P
2AX
2FS
2WC
3O-
4.4
53G
5RE
5VS
79B
85S
AACGO
AAFWJ
AANCE
AAYJJ
ABBHK
ABOCM
ABPLY
ABPPZ
ABTLG
ABXSQ
ABZEH
ACGOD
ACIWK
ACNCT
ACPRK
ADULT
ADZLD
AENEX
AEUPB
AEXZC
AFDAS
AFFNX
AFOSN
AFRAH
ALMA_UNASSIGNED_HOLDINGS
AQVQM
ASUFR
AS~
BKOMP
CS3
D0L
DCCCD
DIK
DNJUQ
DOOOF
DU5
DWIUU
E3Z
EBS
EJD
F20
F5P
FRP
GX1
HGD
HH5
HQ3
HTVGU
HYE
JAAYA
JBMMH
JENOY
JHFFW
JKQEH
JLS
JLXEF
JPM
JSG
JSODD
JST
KQ8
L7B
LU7
MVM
N9A
NEJ
N~3
O9-
OK1
P-O
PNE
PQQKQ
R.V
RHF
RHI
RNA
RNS
RPM
RXW
SA0
SJN
TAE
TN5
UKR
VOH
VQA
W8F
WH7
WHG
WOQ
WOW
X7M
XFK
XSW
Y6R
YBH
YKV
YSK
ZA5
ZCA
ZCG
~02
~KM
-
02
08R
0R
1AW
55
AAPBV
ABFLS
ABPTK
ADACO
AJYGW
AS
DZ
GJ
KM
OHM
PQEST
X
XHC
ADACV
CGR
CUY
CVF
ECM
EIF
H13
IPSME
NPM
AAYXX
CITATION
7QG
7QL
7QP
7QR
7SN
7SS
7T5
7TK
7TM
7TO
7U9
8FD
C1K
FR3
H94
M7N
P64
RC3
7X8
5PM
ID FETCH-LOGICAL-c592t-fa81c99d2dddb7b5ed1c1c79f85fabe63cd43135f15166be229538abb8022d573
IEDL.DBID RPM
ISSN 0027-8424
IngestDate Tue Sep 17 21:25:21 EDT 2024
Sat Oct 26 05:28:15 EDT 2024
Fri Oct 25 06:17:13 EDT 2024
Thu Oct 10 20:18:08 EDT 2024
Fri Aug 23 02:53:05 EDT 2024
Thu Oct 24 10:04:07 EDT 2024
Thu May 30 08:53:54 EDT 2019
Wed Nov 11 00:29:39 EST 2020
Fri Feb 02 07:04:46 EST 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 23
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c592t-fa81c99d2dddb7b5ed1c1c79f85fabe63cd43135f15166be229538abb8022d573
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
Communicated by Neal L. First, University of Wisconsin, Madison, WI, September 8, 2003
Abbreviations: EC, embryonal carcinoma; ES, embryonic stem; GCT, germ cell tumor; ICM, inner cell mass; PGC, primordial germ cell; SAM, significance analysis of microarrays; YSC, yolk sac carcinoma.
To whom correspondence may be addressed at: 1220 Capitol Court, Madison, WI 53715; e-mail: thomson@primate.wisc.edu (for J.A.T.); or Beckman B400, Stanford, CA 94305-5307; e-mail: patrick.brown@stanford.edu (for P.O.B.).
J.M.S. and X.C. contributed equally to this work.
OpenAccessLink https://europepmc.org/articles/pmc263817?pdf=render
PMID 14595015
PQID 201330563
PQPubID 42026
PageCount 6
ParticipantIDs proquest_miscellaneous_71363685
pnas_primary_100_23_13350
pubmedcentral_primary_oai_pubmedcentral_nih_gov_263817
crossref_primary_10_1073_pnas_2235735100
pubmed_primary_14595015
proquest_journals_201330563
pnas_primary_100_23_13350_fulltext
jstor_primary_3148143
proquest_miscellaneous_19262127
ProviderPackageCode RNA
PNE
PublicationCentury 2000
PublicationDate 2003-11-11
PublicationDateYYYYMMDD 2003-11-11
PublicationDate_xml – month: 11
  year: 2003
  text: 2003-11-11
  day: 11
PublicationDecade 2000
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: Washington
PublicationTitle Proceedings of the National Academy of Sciences - PNAS
PublicationTitleAlternate Proc Natl Acad Sci U S A
PublicationYear 2003
Publisher National Academy of Sciences
National Acad Sciences
Publisher_xml – name: National Academy of Sciences
– name: National Acad Sciences
References e_1_3_2_49_2
e_1_3_2_28_2
(e_1_3_2_25_2) 1972; 2
(e_1_3_2_20_2) 1967; 38
(e_1_3_2_26_2) 1974; 77
e_1_3_2_41_2
e_1_3_2_43_2
e_1_3_2_22_2
e_1_3_2_45_2
(e_1_3_2_50_2) 1982; 2
e_1_3_2_24_2
e_1_3_2_47_2
(e_1_3_2_23_2) 1988; 948
(e_1_3_2_29_2) 1984; 50
e_1_3_2_9_2
e_1_3_2_16_2
e_1_3_2_37_2
e_1_3_2_7_2
e_1_3_2_18_2
e_1_3_2_39_2
e_1_3_2_1_2
e_1_3_2_54_2
e_1_3_2_10_2
e_1_3_2_31_2
e_1_3_2_52_2
e_1_3_2_5_2
e_1_3_2_12_2
e_1_3_2_3_2
e_1_3_2_14_2
e_1_3_2_35_2
(e_1_3_2_36_2) 1980; 40
e_1_3_2_27_2
e_1_3_2_48_2
e_1_3_2_40_2
e_1_3_2_21_2
e_1_3_2_42_2
e_1_3_2_44_2
(e_1_3_2_33_2) 1988; 59
e_1_3_2_46_2
e_1_3_2_15_2
e_1_3_2_38_2
e_1_3_2_8_2
e_1_3_2_17_2
e_1_3_2_6_2
e_1_3_2_19_2
e_1_3_2_30_2
e_1_3_2_53_2
e_1_3_2_51_2
e_1_3_2_11_2
e_1_3_2_34_2
e_1_3_2_4_2
e_1_3_2_13_2
e_1_3_2_55_2
e_1_3_2_2_2
(e_1_3_2_32_2) 1983; 10
References_xml – ident: e_1_3_2_39_2
  doi: 10.1038/35021093
– ident: e_1_3_2_10_2
  doi: 10.1101/gad.1020502
– ident: e_1_3_2_38_2
  doi: 10.1006/dbio.2000.9912
– volume: 40
  start-page: 2500
  year: 1980
  ident: e_1_3_2_36_2
  publication-title: Cancer Res.
– ident: e_1_3_2_5_2
  doi: 10.1101/gad.966002
– ident: e_1_3_2_9_2
  doi: 10.1074/jbc.271.38.23126
– ident: e_1_3_2_8_2
  doi: 10.1101/gad.9.21.2635
– ident: e_1_3_2_48_2
  doi: 10.1038/ng1045
– ident: e_1_3_2_18_2
  doi: 10.1126/science.1073823
– ident: e_1_3_2_49_2
  doi: 10.1038/nbt761
– ident: e_1_3_2_52_2
  doi: 10.1038/sj.onc.1206302
– ident: e_1_3_2_2_2
  doi: 10.1073/pnas.78.12.7634
– ident: e_1_3_2_7_2
  doi: 10.1002/(SICI)1520-6408(1996)19:1<51::AID-DVG6>3.0.CO;2-#
– ident: e_1_3_2_19_2
  doi: 10.1016/S0012-1606(03)00256-2
– ident: e_1_3_2_35_2
  doi: 10.1002/ijc.2910290507
– ident: e_1_3_2_15_2
  doi: 10.1101/gad.12.13.2048
– ident: e_1_3_2_51_2
  doi: 10.1038/sj.onc.1203950
– ident: e_1_3_2_3_2
  doi: 10.1002/j.1460-2075.1989.tb08393.x
– ident: e_1_3_2_43_2
  doi: 10.1002/(SICI)1521-1878(199809)20:9<722::AID-BIES5>3.0.CO;2-I
– ident: e_1_3_2_42_2
  doi: 10.1073/pnas.091062498
– volume: 38
  start-page: 549
  year: 1967
  ident: e_1_3_2_20_2
  publication-title: J. Natl. Cancer Inst.
– ident: e_1_3_2_21_2
  doi: 10.1016/B978-1-4831-9953-5.50005-6
– volume: 59
  start-page: 328
  year: 1988
  ident: e_1_3_2_33_2
  publication-title: Lab. Invest.
– ident: e_1_3_2_46_2
  doi: 10.1038/nature00927
– ident: e_1_3_2_28_2
  doi: 10.1016/B978-0-12-333530-2.50021-6
– ident: e_1_3_2_27_2
  doi: 10.1634/stemcells.20-4-329
– volume: 2
  start-page: 1349
  year: 1982
  ident: e_1_3_2_50_2
  publication-title: Lancet
– ident: e_1_3_2_55_2
  doi: 10.1038/nbt788
– ident: e_1_3_2_44_2
  doi: 10.1038/74199
– ident: e_1_3_2_11_2
  doi: 10.1101/gad.224503
– ident: e_1_3_2_1_2
  doi: 10.1038/292154a0
– ident: e_1_3_2_14_2
  doi: 10.1016/0012-1606(92)90174-F
– ident: e_1_3_2_47_2
  doi: 10.1093/nar/gkg014
– ident: e_1_3_2_17_2
  doi: 10.1126/science.1072530
– ident: e_1_3_2_53_2
  doi: 10.1016/S0960-9822(01)00144-0
– ident: e_1_3_2_4_2
  doi: 10.1016/S0092-8674(00)81769-9
– ident: e_1_3_2_24_2
  doi: 10.1159/000474691
– ident: e_1_3_2_41_2
  doi: 10.1073/pnas.95.25.14863
– ident: e_1_3_2_54_2
  doi: 10.1634/stemcells.21-1-111
– ident: e_1_3_2_31_2
  doi: 10.1111/j.1432-0436.1989.tb00602.x
– ident: e_1_3_2_22_2
  doi: 10.1016/0092-8674(92)90317-6
– volume: 10
  start-page: 597
  year: 1983
  ident: e_1_3_2_32_2
  publication-title: Cold Spring Harbor Conferences on Cell Proliferation
– ident: e_1_3_2_16_2
  doi: 10.1126/science.282.5391.1145
– volume: 948
  start-page: 17
  year: 1988
  ident: e_1_3_2_23_2
  publication-title: Biochim. Biophys. Acta
– volume: 2
  start-page: 516
  year: 1972
  ident: e_1_3_2_25_2
  publication-title: Lancet
– volume: 50
  start-page: 147
  year: 1984
  ident: e_1_3_2_29_2
  publication-title: Lab. Invest.
– ident: e_1_3_2_40_2
  doi: 10.1038/35000501
– ident: e_1_3_2_13_2
  doi: 10.1016/S0092-8674(03)00392-1
– volume: 77
  start-page: 103
  year: 1974
  ident: e_1_3_2_26_2
  publication-title: Am. J. Pathol.
– ident: e_1_3_2_45_2
  doi: 10.1016/S0925-4773(02)00242-3
– ident: e_1_3_2_6_2
  doi: 10.1006/dbio.1997.8777
– ident: e_1_3_2_30_2
  doi: 10.1002/ijc.2910400309
– ident: e_1_3_2_34_2
  doi: 10.1002/ijc.2910260304
– ident: e_1_3_2_37_2
  doi: 10.1002/1097-0142(19850601)55:11<2584::AID-CNCR2820551110>3.0.CO;2-B
– ident: e_1_3_2_12_2
  doi: 10.1016/S0092-8674(03)00393-3
SSID ssj0009580
Score 2.4058874
Snippet Remarkably little is known about the transcriptional profiles of human embryonic stem (ES) cells or the molecular mechanisms that underlie their pluripotency....
SourceID pubmedcentral
proquest
crossref
pubmed
pnas
jstor
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 13350
SubjectTerms Biological Sciences
Biology
Carcinoma, Embryonal - genetics
Carcinoma, Embryonal - metabolism
Cell Differentiation
Cell lines
Cells
Chromosome Mapping
Cluster Analysis
Comparative analysis
DNA, Complementary - metabolism
Down-Regulation
Embryo, Mammalian - cytology
Embryonal Carcinoma Stem Cells
Embryonic stem cells
Embryos
Gene expression
Gene Expression Regulation, Developmental
Genes
Germ cells
Humans
Neoplasms, Germ Cell and Embryonal - genetics
Neoplasms, Germ Cell and Embryonal - metabolism
Neoplastic Stem Cells - metabolism
Oligonucleotide Array Sequence Analysis
Phenotype
Pluripotent stem cells
RNA, Messenger - metabolism
Seminoma
Seminoma - genetics
Somatic cells
Stem cells
Stem Cells - metabolism
Tumor cell line
Up-Regulation
Title Gene Expression Patterns in Human Embryonic Stem Cells and Human Pluripotent Germ Cell Tumors
URI https://www.jstor.org/stable/3148143
http://www.pnas.org/content/100/23/13350.abstract
https://www.ncbi.nlm.nih.gov/pubmed/14595015
https://www.proquest.com/docview/201330563
https://search.proquest.com/docview/19262127
https://search.proquest.com/docview/71363685
https://pubmed.ncbi.nlm.nih.gov/PMC263817
Volume 100
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZoT1wQhQKhPCzEoRyyu7ZjJzmiiqpCKuJApV6Q5Ses1PVGm6wE_56x4-y2iF6Qcog044fG4_FMMv4GofeV1p62moD186KsPAQoympf2gWEE15ZYkm8O3z5RVxcVZ-v-XW-FNbntMpg9HIWblazsPyZciu7lZlPeWLzr5dnVERcufkBOqgZmyL0HdBuM147oWB9K1pNcD41m3dB9TMa8V0YaGKqAVfxli9iSdxbh9KYlxjBToH_X47n3_mTtw6k88foUfYk8cdxxkfogQtP0FHeqz0-zYDSH56i7_EVu1855zXgLoFqhh4vA05F-rBb6c3viJKLI7Azjp_ze6yCzeTuZgvGZQ3-9YB_gC1PDHjYrtab_hhdnX_6dnZR5rIKpeEtHUqvGmLa1lJrra41d5YYYurWN9wr7QQzFrwKxj04A0JoFwt-s0ZpHW_lWhDeM3QY1sG9QJjFCJeoypBaVJpDH5ouKsUbUzcGDv4CnU5yld2IniHTX--ayShduV-NAh0nue_4GARq4MwVqEic--YLSZmEgTm0eXcvTfqcPFOgk2kFZd6fMC54vjF4gu7f7qiwsaL0VHDrbS9JRFIktL6fA-J7EfH7C_R81If9RLJeFUjc0ZQdQwT1vksBXU_g3qNuv_zfhifo4ZhuSOB5hQ6Hzda9Brdp0G_SPvkD4BsXIg
link.rule.ids 230,315,733,786,790,891,27955,27956,53825,53827
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Pb9MwFLZgHOACDAaEAbMQh3FIW9txfhzRxFRgnTis0i7Iiu14VKxu1CQS8Nfz7DjtNrEDSD1Ues9J0_dsf0_5_D2E3iVSGlpIAqufSePEQIFSamliPYFywpSaaOLODs9O0-k8-XzOz8OhsCbQKq2Si5G9XI7s4rvnVtZLNR54YuOvsyOaOl258V10D6Yr5UONvpHazfuDJxTW34Qmg6BPxsa1LZsRdQovDHLRd4FLeMEnrinulW2pZyY6uVPw_xv0vMmgvLIlHT9C8-FheibKj1HXypH6fUPn8V-f9jF6GDAq_tBbd9Gdyj5Bu2EVaPBhkKp-_xR9c19x9TOwaS2uvVynbfDCYt_-D1dLuf7l9Hexk4zG7kVBg0urg7m-7GDZWgFyb_EF7BLeAbfdcrVu9tD8-OPZ0TQODRtixQvaxqbMiSoKTbXWMpO80kQRlRUm56aUVcqUBrzCuAGYkaaycq3EWV5K6c77agjKM7RjV7Z6gTBztTMpE0WyNJEcriHpJCl5rrJcAaSI0OEQL1H3uhzCv0_PmHBRE9soR2jPx3Pjx6AEBJgYoch7bodPBGUCbsxhzNtbbcIEWk6E9ofMEGHmw30BU7uyDC5_sLHClHX_XmmrVdcI4jQaCc1u98gIS11ngAg97_Ns-0NCvkYovZaBGwcnF37dAnnlZcP7PHr5vwMP0P3p2exEnHw6_bKPHvSkRgKfV2inXXfVawBnrXzj5-Ifr7A44g
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6VIiEulEIpoUAtxKEckqyd9xEVVuXRqgcqlQOK_IhhRdcbbRKp8OsZO8luW9FLpT2s5HGy2RmPv1E-fwPwNhZCs0JQzH469WONBQpXQvtqguWE5ooqas8OH5-kR2fx5_PkfAPy8SyMI-1LMQvMxTwws1-OW1nPZTjyxMLT40OWWl25sFY6vAf3ccmybKzTV3K7eX_4hGEOjlk8ivpkUVgb3gTMqrxEGI-uE1ycFMnENsa9sjX17EQreYr2_4OfN1mUV7al6RZ8Hx-oZ6P8DrpWBPLvDa3HuzzxY3g0YFXyvrfYho3KPIHtIRs05GCQrH73FH7Yr6S6HFi1htROttM0ZGaIawNIqrlY_rE6vMRKRxP7wqAh3KhhuL7oMH0tEMG35CfuFs6AtN18sWx24Gz68dvhkT80bvBlUrDW1zynsigUU0qJTCSVopLKrNB5ormo0kgqxC1RohFupKmobEvxKOdC2HO_Ch3zDDbNwlTPgUS2hqY8ljRLY5HgNQSbxDzJZZZLhBYeHIw-K-ten6N079WzqLSeK9ee9mDH-XRlF2EpiHDRA89ZrqdPShaVeOME57y5dazUAz3Hg70xOsohA-B9EVvb8gwvv78axaVr_z1uqkXXlNRqNVKW3W6R0Si1HQI82O1jbf1Dhpj1IL0WhSsDKxt-fQRjy8mH97H04q4T9-HB6Ydp-fXTyZc9eNhzGyl-XsJmu-yqV4jRWvHaLcd_cY47Yg
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Gene+Expression+Patterns+in+Human+Embryonic+Stem+Cells+and+Human+Pluripotent+Germ+Cell+Tumors&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+-+PNAS&rft.au=Sperger%2C+Jamie+M.&rft.au=Chen%2C+Xin&rft.au=Draper%2C+Jonathan+S.&rft.au=Antosiewicz%2C+Jessica+E.&rft.date=2003-11-11&rft.pub=National+Academy+of+Sciences&rft.issn=0027-8424&rft.eissn=1091-6490&rft.volume=100&rft.issue=23&rft.spage=13350&rft.epage=13355&rft_id=info:doi/10.1073%2Fpnas.2235735100&rft.externalDocID=3148143
thumbnail_m http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.pnas.org%2Fcontent%2F100%2F23.cover.gif
thumbnail_s http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.pnas.org%2Fcontent%2F100%2F23.cover.gif