Gene Expression Patterns in Human Embryonic Stem Cells and Human Pluripotent Germ Cell Tumors
Remarkably little is known about the transcriptional profiles of human embryonic stem (ES) cells or the molecular mechanisms that underlie their pluripotency. To identify commonalties among the transcriptional profiles of different human pluripotent cells and to search for clues into the genesis of...
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| Published in | Proceedings of the National Academy of Sciences - PNAS Vol. 100; no. 23; pp. 13350 - 13355 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
National Academy of Sciences
11.11.2003
National Acad Sciences |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Remarkably little is known about the transcriptional profiles of human embryonic stem (ES) cells or the molecular mechanisms that underlie their pluripotency. To identify commonalties among the transcriptional profiles of different human pluripotent cells and to search for clues into the genesis of human germ cell tumors, we compared the expression profiles of human ES cell lines, human germ cell tumor cell lines and tumor samples, somatic cell lines, and testicular tissue samples by using cDNA microarray analysis. Hierarchical cluster analysis of gene expression profiles showed that the five independent human ES cell lines clustered tightly together, reflecting highly similar expression profiles. The gene expression patterns of human ES cell lines showed many similarities with the human embryonal carcinoma cell samples and more distantly with the seminoma samples. We identified 895 genes that were expressed at significantly greater levels in human ES and embryonal carcinoma cell lines than in control samples. These genes are candidates for involvement in the maintenance of a pluripotent, undifferentiated phenotype. |
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| AbstractList | Remarkably little is known about the transcriptional profiles of human embryonic stem (ES) cells or the molecular mechanisms that underlie their pluripotency. To identify commonalties among the transcriptional profiles of different human pluripotent cells and to search for clues into the genesis of human germ cell tumors, we compared the expression profiles of human ES cell lines, human germ cell tumor cell lines and tumor samples, somatic cell lines, and testicular tissue samples by using cDNA microarray analysis. Hierarchical cluster analysis of gene expression profiles showed that the five independent human ES cell lines clustered tightly together, reflecting highly similar expression profiles. The gene expression patterns of human ES cell lines showed many similarities with the human embryonal carcinoma cell samples and more distantly with the seminoma samples. We identified 895 genes that were expressed at significantly greater levels in human ES and embryonal carcinoma cell lines than in control samples. These genes are candidates for involvement in the maintenance of a pluripotent, undifferentiated phenotype. Remarkably little is known about the transcriptional profiles of human embryonic stem (ES) cells or the molecular mechanisms that underlie their pluripotency. To identify commonalties among the transcriptional profiles of different human pluripotent cells and to search for clues into the genesis of human germ cell tumors, we compared the expression profiles of human ES cell lines, human germ cell tumor cell lines and tumor samples, somatic cell lines, and testicular tissue samples by using cDNA microarray analysis. Hierarchical cluster analysis of gene expression profiles showed that the five independent human ES cell lines clustered tightly together, reflecting highly similar expression profiles. The gene expression patterns of human ES cell lines showed many similarities with the human embryonal carcinoma cell samples and more distantly with the seminoma samples. We identified 895 genes that were expressed at significantly greater levels in human ES and embryonal carcinoma cell lines than in control samples. These genes are candidates for involvement in the maintenance of a pluripotent, undifferentiated phenotype. [PUBLICATION ABSTRACT] |
| Author | Thomson, James A. Chen, Xin Draper, Jonathan S. Andrews, Peter W. Sperger, Jamie M. Antosiewicz, Jessica E. Chon, Chris H. Brooks, James D. Jones, Sunita B. Brown, Patrick O. |
| AuthorAffiliation | Wisconsin National Primate Research Center and †† Department of Anatomy, School of Medicine, University of Wisconsin, Madison, WI 53715; ‡ Howard Hughes Medical Institute, Departments of ¶ Urology and ∥ Biochemistry, Stanford University School of Medicine, Stanford, CA 94305; and § Department of Biomedical Science, University of Sheffield, Sheffield S10 27N, United Kingdom |
| AuthorAffiliation_xml | – name: Wisconsin National Primate Research Center and †† Department of Anatomy, School of Medicine, University of Wisconsin, Madison, WI 53715; ‡ Howard Hughes Medical Institute, Departments of ¶ Urology and ∥ Biochemistry, Stanford University School of Medicine, Stanford, CA 94305; and § Department of Biomedical Science, University of Sheffield, Sheffield S10 27N, United Kingdom |
| Author_xml | – sequence: 1 givenname: Jamie M. surname: Sperger fullname: Sperger, Jamie M. – sequence: 2 givenname: Xin surname: Chen fullname: Chen, Xin – sequence: 3 givenname: Jonathan S. surname: Draper fullname: Draper, Jonathan S. – sequence: 4 givenname: Jessica E. surname: Antosiewicz fullname: Antosiewicz, Jessica E. – sequence: 5 givenname: Chris H. surname: Chon fullname: Chon, Chris H. – sequence: 6 givenname: Sunita B. surname: Jones fullname: Jones, Sunita B. – sequence: 7 givenname: James D. surname: Brooks fullname: Brooks, James D. – sequence: 8 givenname: Peter W. surname: Andrews fullname: Andrews, Peter W. – sequence: 9 givenname: Patrick O. surname: Brown fullname: Brown, Patrick O. – sequence: 10 givenname: James A. surname: Thomson fullname: Thomson, James A. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/14595015$$D View this record in MEDLINE/PubMed |
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| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 Communicated by Neal L. First, University of Wisconsin, Madison, WI, September 8, 2003 Abbreviations: EC, embryonal carcinoma; ES, embryonic stem; GCT, germ cell tumor; ICM, inner cell mass; PGC, primordial germ cell; SAM, significance analysis of microarrays; YSC, yolk sac carcinoma. To whom correspondence may be addressed at: 1220 Capitol Court, Madison, WI 53715; e-mail: thomson@primate.wisc.edu (for J.A.T.); or Beckman B400, Stanford, CA 94305-5307; e-mail: patrick.brown@stanford.edu (for P.O.B.). J.M.S. and X.C. contributed equally to this work. |
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| Snippet | Remarkably little is known about the transcriptional profiles of human embryonic stem (ES) cells or the molecular mechanisms that underlie their pluripotency.... |
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| SubjectTerms | Biological Sciences Biology Carcinoma, Embryonal - genetics Carcinoma, Embryonal - metabolism Cell Differentiation Cell lines Cells Chromosome Mapping Cluster Analysis Comparative analysis DNA, Complementary - metabolism Down-Regulation Embryo, Mammalian - cytology Embryonal Carcinoma Stem Cells Embryonic stem cells Embryos Gene expression Gene Expression Regulation, Developmental Genes Germ cells Humans Neoplasms, Germ Cell and Embryonal - genetics Neoplasms, Germ Cell and Embryonal - metabolism Neoplastic Stem Cells - metabolism Oligonucleotide Array Sequence Analysis Phenotype Pluripotent stem cells RNA, Messenger - metabolism Seminoma Seminoma - genetics Somatic cells Stem cells Stem Cells - metabolism Tumor cell line Up-Regulation |
| Title | Gene Expression Patterns in Human Embryonic Stem Cells and Human Pluripotent Germ Cell Tumors |
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