Selective hepatitis B virus vaccination has reduced hepatitis B virus transmission in the Netherlands

• Published in: PloS one Vol. 8; no. 7; p. e67866
• Main Authors: Hahné, Susan, van Houdt, Robin, Koedijk, Femke, van Ballegooijen, Marijn, Cremer, Jeroen, Bruisten, Sylvia, Coutinho, Roel, Boot, Hein
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 29.07.2013; Public Library of Science (PLoS)
• Subjects: Adult; Adults; Antigens; Base Sequence; Bayes Theorem; Coalescence; Coalescing; Disease control; Drug abuse; Female; Gene sequencing; Genetic diversity; Genetic Variation; Genomes; Genotype; Health services; Health surveillance; Hepatitis; Hepatitis B; Hepatitis B - epidemiology; Hepatitis B - immunology; Hepatitis B - prevention & control; Hepatitis B - transmission; Hepatitis B Vaccines - immunology; Hepatitis B virus; Hepatitis B virus - genetics; Hepatitis B virus - immunology; Humans; Immunization; Incidence; Infections; Infectious diseases; Inhabitants; Laboratories; Male; Medicine; Men; Mens health; Molecular Sequence Data; Netherlands - epidemiology; Patients; Prostitution; Public health; Risk; Risk groups; Sex; Surveillance; Vaccination; Vaccines; Viruses; Workers; Netherlands
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0067866

In the Netherlands, a selective hepatitis B virus (HBV) vaccination programme started in 2002 for men having sex with men, drug users, commercial sex workers and heterosexuals with frequent partner changes. We assessed the programme's effectiveness to guide policy on HBV prevention. We analysed reports of acute HBV infection in the Netherlands between 2004 and 2010 requesting serum from patients for HBV-genome S- and C-region sequencing. We used coalescence analyses to assess genetic diversity of nonimported genotype-A cases over time. 1687 patients with acute HBV infection were reported between 2004 and 2010. The incidence of reported acute HBV infection decreased from 1.8 to 1.2 per 100,000 inhabitants, mostly due to a reduction in the number of cases in men who have sex with men. Men were overrepresented among cases with an unknown route of transmission, especially among genotype A2 cases mainly associated with transmission through male homosexual contact. The genetic diversity of nonimported genotype-A strains obtained from men who have sex with men decreased from 2006 onwards, suggesting HBV incidence in this group decreased. The selective HBV-vaccination programme for behavioural high-risk groups very likely reduced the incidence of HBV infection in the Netherlands mainly by preventing HBV infections in men who have sex with men. A considerable proportion of cases in men who did not report risk behaviour was probably acquired through homosexual contact. Our findings support continuation of the programme, and adopting similar approaches in other countries where HBV transmission is focused in high-risk adults.