In Vitro Antibiotic Susceptibility of Francisella tularensis Isolates from Japan

The antibiotic susceptibilities of 36 isolates of Japanese Francisella tularensis, an etiological agent of the zoonotic disease tularemia, were analyzed using the E test. All the isolates were susceptible to ciprofloxacin, doxycycline, erythromycin, and gentamicin but resistant to benzylpenicillin a...

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Published inJapanese Journal of Infectious Diseases Vol. 66; no. 6; pp. 534 - 536
Main Authors Hotta, Akitoyo, Fujita, Osamu, Uda, Akihiko, Sharma, Neekun, Tanabayashi, Kiyoshi, Yamamoto, Yoshie, Yamada, Akio, Morikawa, Shigeru
Format Journal Article
LanguageEnglish
Published Japan National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee 2013
Subjects
Anti-Bacterial Agents - pharmacology
antibiotics
Francisella tularensis
Francisella tularensis - drug effects
Francisella tularensis - isolation & purification
Humans
Japan
Microbial Sensitivity Tests
Tularemia - microbiology
Japan
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Summary:The antibiotic susceptibilities of 36 isolates of Japanese Francisella tularensis, an etiological agent of the zoonotic disease tularemia, were analyzed using the E test. All the isolates were susceptible to ciprofloxacin, doxycycline, erythromycin, and gentamicin but resistant to benzylpenicillin and cephalothin. The susceptibility to seven other β-lactams (aztreonam, cefotaxime, cefoxitin, ceftriaxone, cefuroxime, imipenem, and meropenem) varied among the isolates. These findings suggest that the guidelines for the antibiotic treatment of tularemia issued by the World Health Organization are appropriate for Japanese tularemia patients.
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ISSN:1344-6304
1884-2836
DOI:10.7883/yoken.66.534