Base Pair Analogs in the Gas Phase

A rotationally resolved electronic spectrum of the gas-phase dimer 2-aminopyridine-2-pyridone, an analog of the adenine-thymine base pair, has been observed and assigned, leading to precise measurements of its moments of inertia and preliminary determinations of its structure. A Watson-Crick configu...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 100; no. 24; pp. 13752 - 13754
Main Authors Roscioli, Joseph R., Pratt, David W.
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences 25.11.2003
National Acad Sciences
Subjects
Aminopyridines - chemistry
Base Pairing
Chemistry
Deoxyribonucleic acid
Dihedral angle
Dimers
DNA
DNA - chemistry
Electronic structure
Fluorescence
Gases
Hydrogen Bonding
Hydrogen bonds
In Vitro Techniques
Models, Molecular
Molecular Structure
Molecules
Monomers
Nucleic Acid Conformation
Physical Sciences
Pyridones - chemistry
Rotational spectra
Spectrometry, Fluorescence
Spectrum analysis
Vapor phases
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Summary:A rotationally resolved electronic spectrum of the gas-phase dimer 2-aminopyridine-2-pyridone, an analog of the adenine-thymine base pair, has been observed and assigned, leading to precise measurements of its moments of inertia and preliminary determinations of its structure. A Watson-Crick configuration results, with N···H-N and N-H···O hydrogen bond lengths of 2.898 and 2.810 Å, respectively. The two bases are found not to be coplanar; a dihedral angle of 6.1° between the base planes is also estimated from the measured moments of inertia. Possible chemical and biological implications of these results are discussed.
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Edited by F. Fleming Crim, University of Wisconsin, Madison, WI, and approved September 25, 2003
This paper was submitted directly (Track II) to the PNAS office.
To whom correspondence should be addressed. E-mail: pratt@pitt.edu.
Abbreviations: TM, transition moment; 2AP, 2-aminopyridine; 2PY, 2-pyridone.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.2333806100