A comparative study of the efficacy of levosulpiride versus paroxetine in premature ejaculation

• Published in: Journal of human reproductive sciences Vol. 13; no. 2; pp. 125 - 132
• Main Authors: Bathla, Manish, Anjum, Shazia, Singh, Angad, Ramesh, Vinutha, Gupta, Parul, Bhusri, Leezu
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.04.2020; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Anxiety; Data collection; Dopamine; Drug therapy; Ejaculation; Erectile dysfunction; index of premature ejaculation; intravaginal ejaculation latency time; Latency; levosulpiride; Males; Original; Paroxetine; Patients; Premature ejaculation; Serotonin; Serotonin uptake inhibitors; Statistical analysis; Studies; Thyroid gland; Vagina; levosulpiride; Index of premature ejaculation; paroxetine; premature ejaculation; intravaginal ejaculation latency time
• ISSN: 0974-1208; 1998-4766
• DOI: 10.4103/jhrs.JHRS_155_19

Background: Premature ejaculation (PME) can be defined as a lack in the normal voluntary control over ejaculation. It is the most common sexual dysfunction encountered by the male populace. In general, these patients presents with distress. Hence, a novel treatment to eliminate their problem is required. Although the role of SSRI has already been established, the high discontinuation rate and other types of sexual dysfunctions associated with SSRIs reduce their efficacy in controlling this menace. Levosulpiride is a new drug indicated in treatment of PE. Aims and Objectives: The objective is to study the efficacy of levosulpiride; paroxetine and their comparison in patients of PE. Methodology: Index of premature ejaculation (IPE) and intravaginal ejaculation latency time (IELT) were used. A total of 36 patients (18 in each group) were included. The patients were assessed at baseline; at 4 weeks' and at 8 weeks' interval. Results: On comparison the score of IPE in domains of ejaculation control, sexual satisfaction, and the total score of IPE were statistically significant on all the three visits. However, the distress score of IPE and the IELT score were statistically not significant between the two groups. Conclusion: No doubt both agents are efficacious in patients of PME but paroxetine is more efficacious than levosulpiride. At the same time, levosulpiride is a lesser studied and used drug hence more research should be done for it.